AJP - Heart and Circulatory Physiology -- Table of Contents (December 1 2009, 297 [6])

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EDITORIAL FOCUS:

Thomas R. Shannon: Ryanodine receptor Ca²⁺ sensitivity and excitation-contraction coupling in muscular dystrophy and heart failure: similar and yet different
Am J Physiol Heart Circ Physiol 297: H1965-H1966, 2009. First published October 16, 2009; doi:10.1152/ajpheart.00945.2009 [Full Text] [PDF]

L. D. Karalliedde and C. T. Kappagoda: The challenge of traditional Chinese medicines for allopathic practitioners
Am J Physiol Heart Circ Physiol 297: H1967-H1969, 2009. First published October 23, 2009; doi:10.1152/ajpheart.00944.2009 [Full Text] [PDF]

Petra Rocic: Differential phosphoinositide 3-kinase signaling: implications for PTCA?
Am J Physiol Heart Circ Physiol 297: H1970-H1971, 2009. First published October 16, 2009; doi:10.1152/ajpheart.00952.2009 [Full Text] [PDF]

Vardaman Buckalew: Is endogenous ouabain a physiological regulator of cardiovascular and renal function?
Am J Physiol Heart Circ Physiol 297: H1972-H1973, 2009. First published October 23, 2009; doi:10.1152/ajpheart.01002.2009 [Full Text] [PDF]

TRANSLATIONAL PHYSIOLOGY:

Yun Bian, Maoyun Sun, Marcy Silver, Kalon K. L. Ho, Mark A. Marchionni, Anthony O. Caggiano, James R. Stone, Ivo Amende, Thomas G. Hampton, James P. Morgan, and Xinhua Yan: Neuregulin-1 attenuated doxorubicin-induced decrease in cardiac troponins
Am J Physiol Heart Circ Physiol 297: H1974-H1983, 2009. First published October 2, 2009; doi:10.1152/ajpheart.01010.2008 [Abstract] [Full Text] [PDF]

Stéphane Massé, Talha Farid, Paul Dorian, Karthikeyan Umapathy, Krishnakumar Nair, John Asta, Heather Ross, Vivek Rao, Elias Sevaptsidis, and Kumaraswamy Nanthakumar: Effect of global ischemia and reperfusion during ventricular fibrillation in myopathic human hearts
Am J Physiol Heart Circ Physiol 297: H1984-H1991, 2009. First published October 9, 2009; doi:10.1152/ajpheart.00101.2009 [Abstract] [Full Text] [PDF]

ARTICLES:

Nina D. Ullrich, Mohammed Fanchaouy, Konstantin Gusev, Natalia Shirokova, and Ernst Niggli: Hypersensitivity of excitation-contraction coupling in dystrophic cardiomyocytes
Am J Physiol Heart Circ Physiol 297: H1992-H2003, 2009. First published September 25, 2009; doi:10.1152/ajpheart.00602.2009 [Abstract] [Full Text] [PDF]

Lei Zhang, Yan Liu, Xiao Ting Lu, Yi Ling Wu, Cheng Zhang, Xiao Ping Ji, Rong Wang, Chun Xi Liu, Jin Bo Feng, Hong Jiang, Xin Sheng Xu, Yu Xia Zhao, and Yun Zhang: Traditional Chinese medication Tongxinluo dose-dependently enhances stability of vulnerable plaques: a comparison with a high-dose simvastatin therapy
Am J Physiol Heart Circ Physiol 297: H2004-H2014, 2009. First published October 2, 2009; doi:10.1152/ajpheart.00208.2009 [Abstract] [Full Text] [PDF]

Daniele Torella, Cosimo Gasparri, Georgina M. Ellison, Antonio Curcio, Angelo Leone, Carla Vicinanza, Valentina Galuppo, Isabella Mendicino, Walter Sacco, Iolanda Aquila, Francesca Chiara Surace, Maria Luposella, Gilda Stillo, Valter Agosti, Claudia Cosentino, Enrico V. Avvedimento, and Ciro Indolfi: Differential regulation of vascular smooth muscle and endothelial cell proliferation in vitro and in vivo by cAMP/PKA-activated p85 ${alpha}$ ^PI3K
Am J Physiol Heart Circ Physiol 297: H2015-H2025, 2009. First published September 25, 2009; doi:10.1152/ajpheart.00738.2009 [Abstract] [Full Text] [PDF] [Supplemental Material]

Maoz Nesher, Moran Dvela, Vincent U. Igbokwe, Haim Rosen, and David Lichtstein: Physiological roles of endogenous ouabain in normal rats
Am J Physiol Heart Circ Physiol 297: H2026-H2034, 2009. First published October 16, 2009; doi:10.1152/ajpheart.00734.2009 [Abstract] [Full Text] [PDF]

Sophie Tamareille, Nehmat Ghaboura, Frederic Treguer, Dalia Khachman, Anne Croué, Daniel Henrion, Alain Furber, and Fabrice Prunier: Myocardial reperfusion injury management: erythropoietin compared with postconditioning
Am J Physiol Heart Circ Physiol 297: H2035-H2043, 2009. First published July 17, 2009; doi:10.1152/ajpheart.00472.2009 [Abstract] [Full Text] [PDF] [Corrigendum]

Natasa Popovic, Eric A. Bridenbaugh, Jessemy D. Neiger, Jin-Jia Hu, Marina Vannucci, Qianxing Mo, Jerome Trzeciakowski, Matthew W. Miller, Theresa W. Fossum, Jay D. Humphrey, and Emily Wilson: Transforming growth factor-β signaling in hypertensive remodeling of porcine aorta
Am J Physiol Heart Circ Physiol 297: H2044-H2053, 2009. First published August 28, 2009; doi:10.1152/ajpheart.01015.2008 [Abstract] [Full Text] [PDF] [Supplemental Tables]

Steffen Bohl, Debra J. Medway, Jeanette Schulz-Menger, Jurgen E. Schneider, Stefan Neubauer, and Craig A. Lygate: Refined approach for quantification of in vivo ischemia-reperfusion injury in the mouse heart
Am J Physiol Heart Circ Physiol 297: H2054-H2058, 2009. First published October 9, 2009; doi:10.1152/ajpheart.00836.2009 [Abstract] [Full Text] [PDF] [Supplemental Video]

Hao-Liang Xu, Francesco Vetri, Hae-Kyung Lee, Shuhua Ye, Chanannait Paisansathan, Lizhen Mao, Fulong Tan, and Dale A. Pelligrino: Estrogen replacement therapy in diabetic ovariectomized female rats potentiates postischemic leukocyte adhesion in cerebral venules via a RAGE-related process
Am J Physiol Heart Circ Physiol 297: H2059-H2067, 2009. First published October 9, 2009; doi:10.1152/ajpheart.00445.2009 [Abstract] [Full Text] [PDF]

Rasmus Aamand, Thomas Dalsgaard, Frank B. Jensen, Ulf Simonsen, Andreas Roepstorff, and Angela Fago: Generation of nitric oxide from nitrite by carbonic anhydrase: a possible link between metabolic activity and vasodilation
Am J Physiol Heart Circ Physiol 297: H2068-H2074, 2009. First published October 9, 2009; doi:10.1152/ajpheart.00525.2009 [Abstract] [Full Text] [PDF]

Shuxia Wang and Yanzhang Li: Expression of constitutively active cGMP-dependent protein kinase inhibits glucose-induced vascular smooth muscle cell proliferation
Am J Physiol Heart Circ Physiol 297: H2075-H2083, 2009. First published August 28, 2009; doi:10.1152/ajpheart.00521.2009 [Abstract] [Full Text] [PDF] [Corrigendum]

Anthony J. Ocon, John Kulesa, Debbie Clarke, Indu Taneja, Marvin S. Medow, and Julian M. Stewart: Increased phase synchronization and decreased cerebral autoregulation during fainting in the young
Am J Physiol Heart Circ Physiol 297: H2084-H2095, 2009. First published October 9, 2009; doi:10.1152/ajpheart.00705.2009 [Abstract] [Full Text] [PDF]

Ratnadeep Basu, Gavin Y. Oudit, Xiuhua Wang, Liyan Zhang, John R. Ussher, Gary D. Lopaschuk, and Zamaneh Kassiri: Type 1 diabetic cardiomyopathy in the Akita (Ins2^WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function
Am J Physiol Heart Circ Physiol 297: H2096-H2108, 2009. First published October 2, 2009; doi:10.1152/ajpheart.00452.2009 [Abstract] [Full Text] [PDF] [Supplemental Figure]

S. Ares-Carrasco, B. Picatoste, A. Benito-Martín, I. Zubiri, A. B. Sanz, M. D. Sánchez-Niño, A. Ortiz, J. Egido, J. Tuñón, and O. Lorenzo: Myocardial fibrosis and apoptosis, but not inflammation, are present in long-term experimental diabetes
Am J Physiol Heart Circ Physiol 297: H2109-H2119, 2009. First published October 9, 2009; doi:10.1152/ajpheart.00157.2009 [Abstract] [Full Text] [PDF] [Supplemental Figure]

Cameron S. Metcalf, Steven Poelzing, Jason G. Little, and Steven L. Bealer: Status epilepticus induces cardiac myofilament damage and increased susceptibility to arrhythmias in rats
Am J Physiol Heart Circ Physiol 297: H2120-H2127, 2009. First published October 9, 2009; doi:10.1152/ajpheart.00724.2009 [Abstract] [Full Text] [PDF]

Hong Cheng, Rong Yan, Suping Li, Yanhong Yuan, Jun Liu, Changgeng Ruan, and Kesheng Dai: Shear-induced interaction of platelets with von Willebrand factor results in glycoprotein Ib ${alpha}$ shedding
Am J Physiol Heart Circ Physiol 297: H2128-H2135, 2009. First published October 9, 2009; doi:10.1152/ajpheart.00107.2009 [Abstract] [Full Text] [PDF]

Rafik Tadros and Jacques Billette: Rate-dependent AV nodal refractoriness: a new functional framework based on concurrent effects of basic and pretest cycle length
Am J Physiol Heart Circ Physiol 297: H2136-H2143, 2009. First published October 9, 2009; doi:10.1152/ajpheart.00712.2009 [Abstract] [Full Text] [PDF] [Supplemental Table]

Chee Chew Lim, Nathan S. Bryan, Mohit Jain, Maria F. Garcia-Saura, Bernadette O. Fernandez, Douglas B. Sawyer, Diane E. Handy, Joseph Loscalzo, Martin Feelisch, and Ronglih Liao: Glutathione peroxidase deficiency exacerbates ischemia-reperfusion injury in male but not female myocardium: insights into antioxidant compensatory mechanisms
Am J Physiol Heart Circ Physiol 297: H2144-H2153, 2009. First published October 2, 2009; doi:10.1152/ajpheart.00673.2009 [Abstract] [Full Text] [PDF]

N. Saouti, N. Westerhof, F. Helderman, J. T. Marcus, N. Stergiopulos, B. E. Westerhof, A. Boonstra, P. E. Postmus, and A. Vonk-Noordegraaf: RC time constant of single lung equals that of both lungs together: a study in chronic thromboembolic pulmonary hypertension
Am J Physiol Heart Circ Physiol 297: H2154-H2160, 2009. First published October 2, 2009; doi:10.1152/ajpheart.00694.2009 [Abstract] [Full Text] [PDF]

Barbara Baragatti, Michal Laniado Schwartzman, Debora Angeloni, Francesca Scebba, Enrica Ciofini, Daria Sodini, Virginia Ottaviano, Simona Nencioni, Aldo Paolicchi, Joan P. Graves, Darryl C. Zeldin, Katherine Gotlinger, Stefano Luin, and Flavio Coceani: EDHF function in the ductus arteriosus: evidence against involvement of epoxyeicosatrienoic acids and 12S-hydroxyeicosatetraenoic acid
Am J Physiol Heart Circ Physiol 297: H2161-H2168, 2009. First published October 2, 2009; doi:10.1152/ajpheart.00576.2009 [Abstract] [Full Text] [PDF] [Supplemental Figures and Tables]

Paolo Spallarossa, Paola Altieri, Concetta Aloi, Silvano Garibaldi, Chiara Barisione, Giorgio Ghigliotti, Giuseppina Fugazza, Antonio Barsotti, and Claudio Brunelli: Doxorubicin induces senescence or apoptosis in rat neonatal cardiomyocytes by regulating the expression levels of the telomere binding factors 1 and 2
Am J Physiol Heart Circ Physiol 297: H2169-H2181, 2009. First published October 2, 2009; doi:10.1152/ajpheart.00068.2009 [Abstract] [Full Text] [PDF]

N. D. Hopkins, D. J. Green, T. M. Tinken, L. Sutton, N. McWhannell, D. H. J. Thijssen, N. T. Cable, G. Stratton, and K. George: Does conduit artery diameter vary according to the anthropometric characteristics of children or men?
Am J Physiol Heart Circ Physiol 297: H2182-H2187, 2009. First published October 16, 2009; doi:10.1152/ajpheart.00228.2009 [Abstract] [Full Text] [PDF]

Naoki Makino, Toyoki Maeda, Jun-ichi Oyama, Yosihiro Higuchi, and Koji Mimori: Improving insulin sensitivity via activation of PPAR- ${gamma}$ increases telomerase activity in the heart of OLETF rats
Am J Physiol Heart Circ Physiol 297: H2188-H2195, 2009. First published October 23, 2009; doi:10.1152/ajpheart.00421.2009 [Abstract] [Full Text] [PDF]

Joost Lumens, Theo Arts, Bernard Broers, Karin A. Boomars, Pieter van Paassen, Frits W. Prinzen, and Tammo Delhaas: Right ventricular free wall pacing improves cardiac pump function in severe pulmonary arterial hypertension: a computer simulation analysis
Am J Physiol Heart Circ Physiol 297: H2196-H2205, 2009. First published October 16, 2009; doi:10.1152/ajpheart.00870.2009 [Abstract] [Full Text] [PDF]

Bettina Reglin, Timothy W. Secomb, and Axel R. Pries: Structural adaptation of microvessel diameters in response to metabolic stimuli: where are the oxygen sensors?
Am J Physiol Heart Circ Physiol 297: H2206-H2219, 2009. First published September 25, 2009; doi:10.1152/ajpheart.00348.2009 [Abstract] [Full Text] [PDF]

T. Alexander Quinn, Santos E. Cabreriza, Marc E. Richmond, Alan D. Weinberg, Jeffrey W. Holmes, and Henry M. Spotnitz: Simultaneous variation of ventricular pacing site and timing with biventricular pacing in acute ventricular failure improves function by interventricular assist
Am J Physiol Heart Circ Physiol 297: H2220-H2226, 2009. First published October 23, 2009; doi:10.1152/ajpheart.00802.2009 [Abstract] [Full Text] [PDF]

Xiaosun Zhou, H. Glenn Bohlen, Joseph L. Unthank, and Steven J. Miller: Abnormal nitric oxide production in aged rat mesenteric arteries is mediated by NAD(P)H oxidase-derived peroxide
Am J Physiol Heart Circ Physiol 297: H2227-H2233, 2009. First published September 25, 2009; doi:10.1152/ajpheart.00325.2009 [Abstract] [Full Text] [PDF]

Brian S. Knight, Nana Sunn, Craig E. Pennell, S. Lee Adamson, and Stephen J. Lye: Developmental regulation of cardiovascular function is dependent on both genotype and environment
Am J Physiol Heart Circ Physiol 297: H2234-H2241, 2009. First published September 25, 2009; doi:10.1152/ajpheart.01338.2008 [Abstract] [Full Text] [PDF]

Ravi Goyal, Ashwani Mittal, Nina Chu, Lijun Shi, Lubo Zhang, and Lawrence D. Longo: Maturation and the role of PKC-mediated contractility in ovine cerebral arteries
Am J Physiol Heart Circ Physiol 297: H2242-H2252, 2009. First published September 11, 2009; doi:10.1152/ajpheart.00681.2009 [Abstract] [Full Text] [PDF]

Kaori Kato, Dai Yamanouchi, Karla Esbona, Kentaro Kamiya, Fan Zhang, K. Craig Kent, and Bo Liu: Caspase-mediated protein kinase C- ${delta}$ cleavage is necessary for apoptosis of vascular smooth muscle cells
Am J Physiol Heart Circ Physiol 297: H2253-H2261, 2009. First published October 16, 2009; doi:10.1152/ajpheart.00274.2009 [Abstract] [Full Text] [PDF] [Supplemental Figures]

Qun Gao, Xiangmin Zhao, Mansoor Ahmad, and Michael S. Wolin: Mitochondrial-derived hydrogen peroxide inhibits relaxation of bovine coronary arterial smooth muscle to hypoxia through stimulation of ERK MAP kinase
Am J Physiol Heart Circ Physiol 297: H2262-H2269, 2009. First published October 23, 2009; doi:10.1152/ajpheart.00817.2009 [Abstract] [Full Text] [PDF]

Cover Caption:

Cover

Cover: Mitochondria (stained with MitoTracker Red) in cultured human coronary arterial endothelial cells (green calcein fluorescence: cell body; blue: nuclei). See Csiszar A, Labinskyy N, Pinto JT, Ballabh P, Zhang H, Losonczy G, Pearson K, de Cabo R, Pacher P, Zhang C, Ungvari Z. Resveratrol induces mitochondrial biogenesis in endothelial cells. Am J Physiol Heart Circ Physiol 297: H13–H20, 2009.