CALL FOR PAPERS:

Jorge A. Rodriguez, Paula De la Cerda, Eileen Collyer, Valerie Decap, Carlos P. Vio, and Victoria Velarde

Cyclooxygenase-2 induction by bradykinin in aortic vascular smooth muscle cells
Am J Physiol Heart Circ Physiol 290: H30-H36, 2006. First published September 2, 2005; doi:10.1152/ajpheart.00349.2005 [Abstract] [Full Text] [PDF]  

Xin Tang, Erik M. Edwards, Blythe B. Holmes, John R. Falck, and William B. Campbell

Role of phospholipase C and diacylglyceride lipase pathway in arachidonic acid release and acetylcholine-induced vascular relaxation in rabbit aorta
Am J Physiol Heart Circ Physiol 290: H37-H45, 2006. First published July 15, 2005; doi:10.1152/ajpheart.00491.2005 [Abstract] [Full Text] [PDF]  

Jean-Hugues Parmentier, Zoran Pavicevic, and Kafait U. Malik

ANG II stimulates phospholipase D through PKC activation in VSMC: implications in adhesion, spreading, and hypertrophy
Am J Physiol Heart Circ Physiol 290: H46-H54, 2006. First published August 19, 2005; doi:10.1152/ajpheart.00769.2005 [Abstract] [Full Text] [PDF]  

Xiang Fang, Shanming Hu, Bingkun Xu, Gary D. Snyder, Shawn Harmon, Jianrong Yao, Yi Liu, Bhavani Sangras, J. R. Falck, Neal L. Weintraub, and Arthur A. Spector

14,15-Dihydroxyeicosatrienoic acid activates peroxisome proliferator-activated receptor-
Am J Physiol Heart Circ Physiol 290: H55-H63, 2006. First published August 19, 2005; doi:10.1152/ajpheart.00427.2005 [Abstract] [Full Text] [PDF] [Figure]  

William B. Campbell, Blythe B. Holmes, John R. Falck, Jorge H. Capdevila, and Kathryn M. Gauthier

Regulation of potassium channels in coronary smooth muscle by adenoviral expression of cytochrome P-450 epoxygenase
Am J Physiol Heart Circ Physiol 290: H64-H71, 2006. First published September 2, 2005; doi:10.1152/ajpheart.00516.2005 [Abstract] [Full Text] [PDF]  

INVITED REVIEWS:

Martin E. Young

The circadian clock within the heart: potential influence on myocardial gene expression, metabolism, and function
Am J Physiol Heart Circ Physiol 290: H1-H16, 2006; doi:10.1152/ajpheart.00582.2005 [Abstract] [Full Text] [PDF]  

Aldo Clerico, Fabio A. Recchia, Claudio Passino, and Michele Emdin

Cardiac endocrine function is an essential component of the homeostatic regulation network: physiological and clinical implications
Am J Physiol Heart Circ Physiol 290: H17-H29, 2006; doi:10.1152/ajpheart.00684.2005 [Abstract] [Full Text] [PDF]  

EDITORIAL FOCUS:

Abdelkarim Sabri and Pamela A. Lucchesi

Editorial Focus  ANG II and cardiac myocyte contractility: p38 is not stressed out!
Am J Physiol Heart Circ Physiol 290: H72-H73, 2006; doi:10.1152/ajpheart.00873.2005 [Full Text] [PDF]  

R. H. Adamson and F. E. Curry

Editorial Focus  Ang-1: Tie-ing up endothelial adhesion?
Am J Physiol Heart Circ Physiol 290: H74-H76, 2006; doi:10.1152/ajpheart.00946.2005 [Full Text] [PDF]  

Tobias Opthof

Editorial Focus  In vivo dispersion in repolarization and arrhythmias in the human heart
Am J Physiol Heart Circ Physiol 290: H77-H78, 2006; doi:10.1152/ajpheart.00954.2005 [Full Text] [PDF]  

TRANSLATIONAL PHYSIOLOGY:

Vijay S. Chauhan, Eugene Downar, Kumaraswamy Nanthakumar, John D. Parker, Heather J. Ross, Wilson Chan, and Peter Picton

Increased ventricular repolarization heterogeneity in patients with ventricular arrhythmia vulnerability and cardiomyopathy: a human in vivo study
Am J Physiol Heart Circ Physiol 290: H79-H86, 2006. First published August 19, 2005; doi:10.1152/ajpheart.00648.2005 [Abstract] [Full Text] [PDF]  

Nandakumar Sambandam, Dominique Morabito, Cory Wagg, Brian N. Finck, Daniel P. Kelly, and Gary D. Lopaschuk

Chronic activation of PPAR is detrimental to cardiac recovery after ischemia
Am J Physiol Heart Circ Physiol 290: H87-H95, 2006. First published September 9, 2005; doi:10.1152/ajpheart.00285.2005 [Abstract] [Full Text] [PDF]  

ARTICLES:

Julieta Palomeque, Luciana Sapia, Roger J. Hajjar, Alicia Mattiazzi, and Martín Vila Petroff

Angiotensin II-induced negative inotropy in rat ventricular myocytes: role of reactive oxygen species and p38 MAPK
Am J Physiol Heart Circ Physiol 290: H96-H106, 2006. First published July 29, 2005; doi:10.1152/ajpheart.00324.2005 [Abstract] [Full Text] [PDF]  

Fabienne Baffert, Tom Le, Gavin Thurston, and Donald M. McDonald

Angiopoietin-1 decreases plasma leakage by reducing number and size of endothelial gaps in venules
Am J Physiol Heart Circ Physiol 290: H107-H118, 2006. First published August 26, 2005; doi:10.1152/ajpheart.00542.2005 [Abstract] [Full Text] [PDF]  

Jurgen W. G. E. VanTeeffelen and Steven S. Segal

Rapid dilation of arterioles with single contraction of hamster skeletal muscle
Am J Physiol Heart Circ Physiol 290: H119-H127, 2006. First published August 12, 2005; doi:10.1152/ajpheart.00197.2005 [Abstract] [Full Text] [PDF]  

Joel P. French, John C. Quindry, Darin J. Falk, Jessica L. Staib, Youngil Lee, Kevin K. W. Wang, and Scott K. Powers

Ischemia-reperfusion-induced calpain activation and SERCA2a degradation are attenuated by exercise training and calpain inhibition
Am J Physiol Heart Circ Physiol 290: H128-H136, 2006. First published September 9, 2005; doi:10.1152/ajpheart.00739.2005 [Abstract] [Full Text] [PDF]  

Hui Chen, Rajaram J. Karne, Gail Hall, Umberto Campia, Julio A. Panza, Richard O. Cannon, III, Yaohui Wang, Arie Katz, Mark Levine, and Michael J. Quon

High-dose oral vitamin C partially replenishes vitamin C levels in patients with Type 2 diabetes and low vitamin C levels but does not improve endothelial dysfunction or insulin resistance
Am J Physiol Heart Circ Physiol 290: H137-H145, 2006. First published August 26, 2005; doi:10.1152/ajpheart.00768.2005 [Abstract] [Full Text] [PDF]  

James J. M. Greer, Derek P. Ware, and David J. Lefer

Myocardial infarction and heart failure in the db/db diabetic mouse
Am J Physiol Heart Circ Physiol 290: H146-H153, 2006. First published August 19, 2005; doi:10.1152/ajpheart.00583.2005 [Abstract] [Full Text] [PDF]  

Jiun-Jr Wang, Jacqueline A. Flewitt, Nigel G. Shrive, Kim H. Parker, and John V. Tyberg

Systemic venous circulation. Waves propagating on a windkessel: relation of arterial and venous windkessels to systemic vascular resistance
Am J Physiol Heart Circ Physiol 290: H154-H162, 2006. First published August 19, 2005; doi:10.1152/ajpheart.00494.2005 [Abstract] [Full Text] [PDF]  

Tetsuo Betsuyaku, Nkiruka S. Nnebe, Rune Sundset, Sushmitha Patibandla, Charles M. Krueger, and Kathryn A. Yamada

Overexpression of cardiac connexin45 increases susceptibility to ventricular tachyarrhythmias in vivo
Am J Physiol Heart Circ Physiol 290: H163-H171, 2006. First published August 26, 2005; doi:10.1152/ajpheart.01308.2004 [Abstract] [Full Text] [PDF]  

Helle Hasager Damkier, Søren Nielsen, and Jeppe Praetorius

An anti-NH₂-terminal antibody localizes NBCn1 to heart endothelia and skeletal and vascular smooth muscle cells
Am J Physiol Heart Circ Physiol 290: H172-H180, 2006. First published August 26, 2005; doi:10.1152/ajpheart.00713.2005 [Abstract] [Full Text] [PDF]  

J. David Symons, John C. Rutledge, U. Simonsen, and Roshny A. Pattathu

Vascular dysfunction produced by hyperhomocysteinemia is more severe in the presence of low folate
Am J Physiol Heart Circ Physiol 290: H181-H191, 2006. First published September 2, 2005; doi:10.1152/ajpheart.00765.2005 [Abstract] [Full Text] [PDF]  

Phillip M. Ecker, Chu-Chuan Lin, Jennifer Powers, Brian K. Kobilka, Anne M. Dubin, and Daniel Bernstein

Effect of targeted deletions of ₁- and ₂-adrenergic-receptor subtypes on heart rate variability
Am J Physiol Heart Circ Physiol 290: H192-H199, 2006. First published August 19, 2005; doi:10.1152/ajpheart.00032.2005 [Abstract] [Full Text] [PDF]  

Kanji Matsukawa, Hidehiko Komine, Tomoko Nakamoto, and Jun Murata

Central command blunts sensitivity of arterial baroreceptor-heart rate reflex at onset of voluntary static exercise
Am J Physiol Heart Circ Physiol 290: H200-H208, 2006. First published August 19, 2005; doi:10.1152/ajpheart.00013.2005 [Abstract] [Full Text] [PDF]  

Katari A. Carello, Steven E. Whitesall, Mary C. Lloyd, Scott S. Billecke, and Louis G. D'Alecy

Asymmetrical dimethylarginine plasma clearance persists after acute total nephrectomy in rats
Am J Physiol Heart Circ Physiol 290: H209-H216, 2006. First published August 19, 2005; doi:10.1152/ajpheart.00208.2005 [Abstract] [Full Text] [PDF]  

Terese M. Zidon and Don D. Sheriff

Diversion of blood flow from noncompliant to compliant vasculature in awake dogs: mechanical impact on right atrial pressure
Am J Physiol Heart Circ Physiol 290: H217-H223, 2006; doi:10.1152/ajpheart.00482.2005 [Abstract] [Full Text] [PDF]  

W. David Merryman, Inchan Youn, Howard D. Lukoff, Paula M. Krueger, Farshid Guilak, Richard A. Hopkins, and Michael S. Sacks

Correlation between heart valve interstitial cell stiffness and transvalvular pressure: implications for collagen biosynthesis
Am J Physiol Heart Circ Physiol 290: H224-H231, 2006. First published August 26, 2005; doi:10.1152/ajpheart.00521.2005 [Abstract] [Full Text] [PDF]  

Merry L. Lindsey, G. Patricia Escobar, Lawrence W. Dobrucki, Danielle K. Goshorn, Shenikqua Bouges, Joseph T. Mingoia, David M. McClister, Jr., Haili Su, Joseph Gannon, Catherine MacGillivray, Richard T. Lee, Albert J. Sinusas, and Francis G. Spinale

Matrix metalloproteinase-9 gene deletion facilitates angiogenesis after myocardial infarction
Am J Physiol Heart Circ Physiol 290: H232-H239, 2006. First published August 26, 2005; doi:10.1152/ajpheart.00457.2005 [Abstract] [Full Text] [PDF]  

M. Keith Wilkerson, Thomas J. Heppner, Adrian D. Bonev, and Mark T. Nelson

Inositol trisphosphate receptor calcium release is required for cerebral artery smooth muscle cell proliferation
Am J Physiol Heart Circ Physiol 290: H240-H247, 2006. First published August 19, 2005; doi:10.1152/ajpheart.01191.2004 [Abstract] [Full Text] [PDF] [Supplemental Movies]  

Guifu Wu, Zhimin Du, Chenghen Hu, Zhensheng Zheng, Chengyang Zhan, Hong Ma, Dianqiu Fang, Khan Tanveer Ahmed, Roger J. Laham, John C. K. Hui, and William E. Lawson

Angiogenic effects of long-term enhanced external counterpulsation in a dog model of myocardial infarction
Am J Physiol Heart Circ Physiol 290: H248-H254, 2006. First published August 19, 2005; doi:10.1152/ajpheart.01225.2004 [Abstract] [Full Text] [PDF]  

Zhilin Qu

Critical mass hypothesis revisited: role of dynamical wave stability in spontaneous termination of cardiac fibrillation
Am J Physiol Heart Circ Physiol 290: H255-H263, 2006. First published August 19, 2005; doi:10.1152/ajpheart.00668.2005 [Abstract] [Full Text] [PDF] [Movie]  

Lauren Mabanta, Patrick Valane, Jonathan Borne, and Mary D. Frame

Initiation of remote microvascular preconditioning requires K_ATP channel activity
Am J Physiol Heart Circ Physiol 290: H264-H271, 2006. First published August 26, 2005; doi:10.1152/ajpheart.00455.2005 [Abstract] [Full Text] [PDF]  

Anthony J. Donato, Abhimanyu Uberoi, D. Walter Wray, Steven Nishiyama, Lesley Lawrenson, and Russell S. Richardson

Differential effects of aging on limb blood flow in humans
Am J Physiol Heart Circ Physiol 290: H272-H278, 2006. First published September 23, 2005; doi:10.1152/ajpheart.00405.2005 [Abstract] [Full Text] [PDF]  

Xiuhua Liu, Tianbo Li, Sheng Sun, Feifei Xu, and Yiguang Wang

Role of myofibrillogenesis regulator-1 in myocardial hypertrophy
Am J Physiol Heart Circ Physiol 290: H279-H285, 2006. First published August 12, 2005; doi:10.1152/ajpheart.00247.2005 [Abstract] [Full Text] [PDF]  

Alex Vidal, Yao Sun, Syamal K. Bhattacharya, Robert A. Ahokas, Ivan C. Gerling, and Karl T. Weber

Calcium paradox of aldosteronism and the role of the parathyroid glands
Am J Physiol Heart Circ Physiol 290: H286-H294, 2006; doi:10.1152/ajpheart.00535.2005 [Abstract] [Full Text] [PDF]  

Rajesh G. Mishra, Frank Z. Stanczyk, Kenneth A. Burry, Suzanne Oparil, Benita S. Katzenellenbogen, Michele L. Nealen, John A. Katzenellenbogen, and R. Kent Hermsmeyer

Metabolite ligands of estrogen receptor- reduce primate coronary hyperreactivity
Am J Physiol Heart Circ Physiol 290: H295-H303, 2006. First published September 30, 2005; doi:10.1152/ajpheart.00468.2005 [Abstract] [Full Text] [PDF]  

Timothy A. Hacker, Susan H. McKiernan, Pamela S. Douglas, Jonathan Wanagat, and Judd M. Aiken

Age-related changes in cardiac structure and function in Fischer 344 x Brown Norway hybrid rats
Am J Physiol Heart Circ Physiol 290: H304-H311, 2006. First published September 2, 2005; doi:10.1152/ajpheart.00290.2005 [Abstract] [Full Text] [PDF]  

Alex Y. Tan, Chung-Chuan Chou, Shengmei Zhou, Motoki Nihei, Chun Hwang, C. Thomas Peter, Michael C. Fishbein, and Peng-Sheng Chen

Electrical connections between left superior pulmonary vein, left atrium, and ligament of Marshall: implications for mechanisms of atrial fibrillation
Am J Physiol Heart Circ Physiol 290: H312-H322, 2006. First published September 9, 2005; doi:10.1152/ajpheart.00369.2005 [Abstract] [Full Text] [PDF]  

Jennifer E. Naugle, Erik R. Olson, Xiaojin Zhang, Sharon E. Mase, Charles F. Pilati, Michael B. Maron, Hans G. Folkesson, Walter I. Horne, Kathleen J. Doane, and J. Gary Meszaros

Type VI collagen induces cardiac myofibroblast differentiation: implications for postinfarction remodeling
Am J Physiol Heart Circ Physiol 290: H323-H330, 2006. First published September 2, 2005; doi:10.1152/ajpheart.00321.2005 [Abstract] [Full Text] [PDF]  

Jochen Müller-Ehmsen, Annette Schmidt, Benjamin Krausgrill, Robert H. G. Schwinger, and Wilhelm Bloch

Role of erythropoetin for angiogenesis and vasculogenesis: from embryonic development through adulthood
Am J Physiol Heart Circ Physiol 290: H331-H340, 2006. First published July 15, 2005; doi:10.1152/ajpheart.01269.2004 [Abstract] [Full Text] [PDF]  

Mark G. Angelos, Vijay K. Kutala, Carlos A. Torres, Guanglong He, Jason D. Stoner, Marwan Mohammad, and Periannan Kuppusamy

Hypoxic reperfusion of the ischemic heart and oxygen radical generation
Am J Physiol Heart Circ Physiol 290: H341-H347, 2006. First published August 26, 2005; doi:10.1152/ajpheart.00223.2005 [Abstract] [Full Text] [PDF]  

Eugene I. Tikh, Richard A. Fenton, and James G. Dobson, Jr.

Contractile effects of adenosine A₁ and A_2A receptors in isolated murine hearts
Am J Physiol Heart Circ Physiol 290: H348-H356, 2006. First published September 2, 2005; doi:10.1152/ajpheart.00740.2005 [Abstract] [Full Text] [PDF]  

Alberto Radaelli, Paolo Castiglioni, Marco Centola, Francesca Cesana, Giulia Balestri, Alberto U. Ferrari, and Marco Di Rienzo

Adrenergic origin of very low-frequency blood pressure oscillations in the unanesthetized rat
Am J Physiol Heart Circ Physiol 290: H357-H364, 2006. First published September 2, 2005; doi:10.1152/ajpheart.00773.2005 [Abstract] [Full Text] [PDF]  

Longkun Zhu and Pingnian He

fMLP-stimulated release of reactive oxygen species from adherent leukocytes increases microvessel permeability
Am J Physiol Heart Circ Physiol 290: H365-H372, 2006. First published September 9, 2005; doi:10.1152/ajpheart.00812.2005 [Abstract] [Full Text] [PDF]  

Harjot K. Saini, Onkar N. Tripathi, Shetuan Zhang, Vijayan Elimban, and Naranjan S. Dhalla

Involvement of Na⁺/Ca²⁺ exchanger in catecholamine-induced increase in intracellular calcium in cardiomyocytes
Am J Physiol Heart Circ Physiol 290: H373-H380, 2006. First published September 9, 2005; doi:10.1152/ajpheart.00613.2005 [Abstract] [Full Text] [PDF]  

Agnes Kenessey, Elizabeth Ann Sullivan, and Kaie Ojamaa

Nuclear localization of protein kinase C- induces thyroid hormone receptor-1 expression in the cardiomyocyte
Am J Physiol Heart Circ Physiol 290: H381-H389, 2006. First published September 9, 2005; doi:10.1152/ajpheart.00576.2005 [Abstract] [Full Text] [PDF]  

Karim Benkirane, Farhad Amiri, Quy N. Diep, Mohammed El Mabrouk, and Ernesto L. Schiffrin

PPAR- inhibits ANG II-induced cell growth via SHIP2 and 4E-BP1
Am J Physiol Heart Circ Physiol 290: H390-H397, 2006. First published September 9, 2005; doi:10.1152/ajpheart.00662.2005 [Abstract] [Full Text] [PDF]  

James A. Brock, Melanie Yeoh, and Elspeth M. McLachlan

Enhanced neurally evoked responses and inhibition of norepinephrine reuptake in rat mesenteric arteries after spinal transection
Am J Physiol Heart Circ Physiol 290: H398-H405, 2006. First published September 2, 2005; doi:10.1152/ajpheart.00712.2005 [Abstract] [Full Text] [PDF]  

Alexandre D. T. Costa, Casey L. Quinlan, Anastasia Andrukhiv, Ian C. West, Martin Jaburek, and Keith D. Garlid

The direct physiological effects of mitoK_ATP opening on heart mitochondria
Am J Physiol Heart Circ Physiol 290: H406-H415, 2006. First published September 2, 2005; doi:10.1152/ajpheart.00794.2005 [Abstract] [Full Text] [PDF]  

Ya-Ching Hsieh, Shaolong Yang, Mashkoor A. Choudhry, Huang-Ping Yu, Kirby I. Bland, Martin G. Schwacha, and Irshad H. Chaudry

Flutamide restores cardiac function after trauma-hemorrhage via an estrogen-dependent pathway through upregulation of PGC-1
Am J Physiol Heart Circ Physiol 290: H416-H423, 2006. First published September 9, 2005; doi:10.1152/ajpheart.00865.2005 [Abstract] [Full Text] [PDF]  

G. D. Pinna, R. Maestri, M. T. La Rovere, E. Gobbi, and F. Fanfulla

Effect of paced breathing on ventilatory and cardiovascular variability parameters during short-term investigations of autonomic function
Am J Physiol Heart Circ Physiol 290: H424-H433, 2006. First published September 9, 2005; doi:10.1152/ajpheart.00438.2005 [Abstract] [Full Text] [PDF]  

David F. Stowe, Mohammed Aldakkak, Amadou K. S. Camara, Matthias L. Riess, Andre Heinen, Srinivasan G. Varadarajan, and Ming-Tao Jiang

Cardiac mitochondrial preconditioning by Big Ca²⁺-sensitive K⁺ channel opening requires superoxide radical generation
Am J Physiol Heart Circ Physiol 290: H434-H440, 2006. First published August 26, 2005; doi:10.1152/ajpheart.00763.2005 [Abstract] [Full Text] [PDF]  

Nataliya V. Solenkova, Viktoriya Solodushko, Michael V. Cohen, and James M. Downey

Endogenous adenosine protects preconditioned heart during early minutes of reperfusion by activating Akt
Am J Physiol Heart Circ Physiol 290: H441-H449, 2006. First published September 9, 2005; doi:10.1152/ajpheart.00589.2005 [Abstract] [Full Text] [PDF]  

Sebastian Philipp, Lin Cui, Barbara Ludolph, Malte Kelm, Rainer Schulz, Michael V. Cohen, and James M. Downey

Desferoxamine and ethyl-3,4-dihydroxybenzoate protect myocardium by activating NOS and generating mitochondrial ROS
Am J Physiol Heart Circ Physiol 290: H450-H457, 2006. First published September 9, 2005; doi:10.1152/ajpheart.00472.2005 [Abstract] [Full Text] [PDF]  

Mirella Gouverneur, Jos A. E. Spaan, Hans Pannekoek, Ruud D. Fontijn, and Hans Vink

Fluid shear stress stimulates incorporation of hyaluronan into endothelial cell glycocalyx
Am J Physiol Heart Circ Physiol 290: H458-H452, 2006. First published August 26, 2005; doi:10.1152/ajpheart.00592.2005 [Abstract] [Full Text] [PDF]  

Bradley M. Palmer, Zengyi Chen, Richard R. Lachapelle, Edith D. Hendley, and Martin M. LeWinter

Cardiomyocyte function associated with hyperactivity and/or hypertension in genetic models of LV hypertrophy
Am J Physiol Heart Circ Physiol 290: H463-H473, 2006. First published October 21, 2005; doi:10.1152/ajpheart.00310.2005 [Abstract] [Full Text] [PDF]  

INNOVATIVE METHODOLOGY:

Ingrid H. Sarelius, Julia M. Kuebel, Jianjie Wang, and Virginia H. Huxley

Macromolecule permeability of in situ and excised rodent skeletal muscle arterioles and venules
Am J Physiol Heart Circ Physiol 290: H474-H480, 2006. First published August 26, 2005; doi:10.1152/ajpheart.00655.2005 [Abstract] [Full Text] [PDF]  

Rima Tahseldar-Roumieh, Rana Ghali-Ghoul, Claire Lugnier, and Ramzi Sabra

Effect of phosphodiesterase 5 inhibitor on alteration in vascular smooth muscle sensitivity and renal function in rats with liver cirrhosis
Am J Physiol Heart Circ Physiol 290: H481-H488, 2006; doi:10.1152/ajpheart.00507.2005 [Abstract] [Full Text] [PDF]  

CORRIGENDA:

Corrigenda
Am J Physiol Heart Circ Physiol 290: H489-H489, 2006; doi:10.1152/ajpheart.01122.2005 [Full Text] [PDF]  

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