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Contents: Volume 289, Issue 6
December 2005 [Index by Author] [Editorial Board]
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= article is free immediately upon publication
(all articles are free one year after publication)
Cover: Modified rodent skinfold chambers are useful preparations for studying the effects of tissue properties on implanted sensors. Chambers support a 200-μm layer of retractor muscle between a glass window and a planar array of electrochemical oxygen sensors, allowing simultaneous imaging of microvascular blood flow and recording of tissue oxygen levels. Microvascular patterns (shown here) and perfusion modulate the concentration-dependent signals of implanted sensors. These studies suggest new approaches to the design of implantable sensors and interpretation of substrate concentrations from their signals. From Makale MT, Chen PC, and Gough DA. “Variants of the tissue-sensor array window chamber.” Am J Physiol Heart Circ Physiol 289: H57–H65, 2005.
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