SPECIAL MEDICAL EDITORIALS:

Ossama A. Hatoum, Hiroto Miura, and David G. Binion

The vascular contribution in the pathogenesis of inflammatory bowel disease
Am J Physiol Heart Circ Physiol 285: 1791-1796, 2003; doi:10.1152/ajpheart.00552.2003 [Full Text] [PDF]  

INVITED REVIEWS:

John P. Headrick, Ben Hack, and Kevin J. Ashton

Acute adenosinergic cardioprotection in ischemic-reperfused hearts
Am J Physiol Heart Circ Physiol 285: 1797-1818, 2003; doi:10.1152/ajpheart.00407.2003 [Abstract] [Full Text] [PDF]  

ARTICLES:

Kenneth A. Schenkman, Daniel A. Beard, Wayne A. Ciesielski, and Eric O. Feigl

Comparison of buffer and red blood cell perfusion of guinea pig heart oxygenation
Am J Physiol Heart Circ Physiol 285: 1819-1825, 2003. First published July 17, 2003; doi:10.1152/ajpheart.00383.2003 [Abstract] [Full Text] [PDF]  

Daniel A. Beard, Kenneth A. Schenkman, and Eric O. Feigl

Myocardial oxygenation in isolated hearts predicted by an anatomically realistic microvascular transport model
Am J Physiol Heart Circ Physiol 285: 1826-1836, 2003. First published July 17, 2003; doi:10.1152/ajpheart.00380.2003 [Abstract] [Full Text] [PDF]  

Alan E. Lomax, Colleen S. Kondo, and Wayne R. Giles

Comparison of time- and voltage-dependent K⁺ currents in myocytes from left and right atria of adult mice
Am J Physiol Heart Circ Physiol 285: 1837-1848, 2003. First published July 17, 2003; doi:10.1152/ajpheart.00386.2003 [Abstract] [Full Text] [PDF]  

Christine E. Miller, Chandra L. Wong, and David Sedmera

Pressure overload alters stress-strain properties of the developing chick heart
Am J Physiol Heart Circ Physiol 285: 1849-1856, 2003. First published July 10, 2003; doi:10.1152/ajpheart.00384.2002 [Abstract] [Full Text] [PDF]  

Gerald F. DiBona and Linda L. Sawin

Losartan corrects abnormal frequency response of renal vasculature in congestive heart failure
Am J Physiol Heart Circ Physiol 285: 1857-1863, 2003. First published June 26, 2003; doi:10.1152/ajpheart.00364.2003 [Abstract] [Full Text] [PDF]  

Owen P. Faris, Frank J. Evans, Alexander J. Dick, Venkatesh K. Raman, Daniel B. Ennis, David A. Kass, and Elliot R. McVeigh

Endocardial versus epicardial electrical synchrony during LV free-wall pacing
Am J Physiol Heart Circ Physiol 285: 1864-1870, 2003. First published July 10, 2003; doi:10.1152/ajpheart.00282.2003 [Abstract] [Full Text] [PDF]  

J. Wang, H. Chen, A. Seth, and C. A. McCulloch

Mechanical force regulation of myofibroblast differentiation in cardiac fibroblasts
Am J Physiol Heart Circ Physiol 285: 1871-1881, 2003. First published July 3, 2003; doi:10.1152/ajpheart.00387.2003 [Abstract] [Full Text] [PDF]  

Pasi Jolma, Peeter Kööbi, Jarkko Kalliovalkama, Mika Kähönen, Meng Fan, Heikki Saha, Heikki Helin, Terho Lehtimäki, and Ilkka Pörsti

Increased calcium intake reduces plasma cholesterol and improves vasorelaxation in experimental renal failure
Am J Physiol Heart Circ Physiol 285: 1882-1889, 2003; doi:10.1152/ajpheart.01148.2002 [Abstract] [Full Text] [PDF]  

Ken Kazama, Gang Wang, Kelly Frys, Josef Anrather, and Costantino Iadecola

Angiotensin II attenuates functional hyperemia in the mouse somatosensory cortex
Am J Physiol Heart Circ Physiol 285: 1890-1899, 2003. First published August 7, 2003; doi:10.1152/ajpheart.00464.2003 [Abstract] [Full Text] [PDF]  

David J. Marcinek, Wayne A. Ciesielski, Kevin E. Conley, and Kenneth A. Schenkman

Oxygen regulation and limitation to cellular respiration in mouse skeletal muscle in vivo
Am J Physiol Heart Circ Physiol 285: 1900-1908, 2003. First published May 29, 2003; doi:10.1152/ajpheart.00192.2003 [Abstract] [Full Text] [PDF]  

Ferran Padilla, David Garcia-Dorado, Antonio Rodríguez-Sinovas, Marisol Ruiz-Meana, Javier Inserte, and Jordi Soler-Soler

Protection afforded by ischemic preconditioning is not mediated by effects on cell-to-cell electrical coupling during myocardial ischemia-reperfusion
Am J Physiol Heart Circ Physiol 285: 1909-1916, 2003. First published July 17, 2003; doi:10.1152/ajpheart.00438.2003 [Abstract] [Full Text] [PDF]  

Cecile J. Favre, Michael Mancuso, Kevin Maas, John W. McLean, Peter Baluk, and Donald M. McDonald

Expression of genes involved in vascular development and angiogenesis in endothelial cells of adult lung
Am J Physiol Heart Circ Physiol 285: 1917-1938, 2003. First published July 3, 2003; doi:10.1152/ajpheart.00983.2002 [Abstract] [Full Text] [PDF]  

Mitsuaki Tanaka, Hiroshi Kanatsuka, Boon-Hooi Ong, Toshinori Tanikawa, Akira Uruno, Tatsuya Komaru, Ryoji Koshida, and Kunio Shirato

Cytochrome P-450 metabolites but not NO, PGI₂, and H₂O₂ contribute to ACh-induced hyperpolarization of pressurized canine coronary microvessels
Am J Physiol Heart Circ Physiol 285: 1939-1948, 2003. First published July 24, 2003; doi:10.1152/ajpheart.00190.2003 [Abstract] [Full Text] [PDF]  

Jun Ming Wang, Shereeni J. Veerasingham, Junhui Tan, and Frans H. H. Leenen

Effects of high salt intake on brain AT₁ receptor densities in Dahl rats
Am J Physiol Heart Circ Physiol 285: 1949-1955, 2003. First published July 3, 2003; doi:10.1152/ajpheart.00744.2002 [Abstract] [Full Text] [PDF]  

Ares Pasipoularides, Ming Shu, Ashish Shah, Alessandro Tucconi, and Donald D. Glower

RV instantaneous intraventricular diastolic pressure and velocity distributions in normal and volume overload awake dog disease models
Am J Physiol Heart Circ Physiol 285: H1956-H1965, 2003. First published July 24, 2003; doi:10.1152/ajpheart.00372.2003 [Abstract] [Full Text] [PDF]  

X. Lu, J. Yang, J. B. Zhao, H. Gregersen, and G. S. Kassab

Shear modulus of porcine coronary artery: contributions of media and adventitia
Am J Physiol Heart Circ Physiol 285: 1966-1975, 2003; doi:10.1152/ajpheart.00357.2003 [Abstract] [Full Text] [PDF]  

A. V. Naumova, R. G. Weiss, and V. P. Chacko

Regulation of murine myocardial energy metabolism during adrenergic stress studied by in vivo ³¹P NMR spectroscopy
Am J Physiol Heart Circ Physiol 285: 1976-1979, 2003. First published July 24, 2003; doi:10.1152/ajpheart.00474.2003 [Abstract] [Full Text] [PDF]  

Darin J. Saltzman, Andras Toth, Amy G. Tsai, Marcos Intaglietta, and Paul C. Johnson

Oxygen tension distribution in postcapillary venules in resting skeletal muscle
Am J Physiol Heart Circ Physiol 285: 1980-1985, 2003. First published July 3, 2003; doi:10.1152/ajpheart.00322.2002 [Abstract] [Full Text] [PDF]  

Ed VanBavel, Pier Siersma, and Jos A. E. Spaan

Elasticity of passive blood vessels: a new concept
Am J Physiol Heart Circ Physiol 285: 1986-2000, 2003. First published July 3, 2003; doi:10.1152/ajpheart.00248.2003 [Abstract] [Full Text] [PDF]  

Martin Farias, III, Keith Jackson, Michael Johnson, and James L. Caffrey

Cardiac enkephalins attenuate vagal bradycardia: interactions with NOS-1-cGMP systems in canine sinoatrial node
Am J Physiol Heart Circ Physiol 285: 2001-2012, 2003. First published July 24, 2003; doi:10.1152/ajpheart.00275.2003 [Abstract] [Full Text] [PDF]  

Hao Wang, Roselyn White, and Frans H. H. Leenen

Stimulation of brain Na⁺ channels by FMRFamide in Dahl SS and SR rats
Am J Physiol Heart Circ Physiol 285: 2013-2018, 2003. First published July 10, 2003; doi:10.1152/ajpheart.00453.2003 [Abstract] [Full Text] [PDF]  

M. Gössl, N. M. Malyar, M. Rosol, P. E. Beighley, and E. L. Ritman

Impact of coronary vasa vasorum functional structure on coronary vessel wall perfusion distribution
Am J Physiol Heart Circ Physiol 285: 2019-2026, 2003. First published July 10, 2003; doi:10.1152/ajpheart.00399.2003 [Abstract] [Full Text] [PDF]  

Andrew W. Bowman and Sándor J. Kovács

Assessment and consequences of the constant-volume attribute of the four-chambered heart
Am J Physiol Heart Circ Physiol 285: 2027-2033, 2003. First published July 17, 2003; doi:10.1152/ajpheart.00249.2003 [Abstract] [Full Text] [PDF] [Supplemental Videos]  

Heike Bruck, Kirsten Leineweber, Anke Ulrich, Joachim Radke, Gerd Heusch, Thomas Philipp, and Otto-Erich Brodde

Thr164Ile polymorphism of the human ₂-adrenoceptor exhibits blunted desensitization of cardiac functional responses in vivo
Am J Physiol Heart Circ Physiol 285: 2034-2038, 2003. First published July 17, 2003; doi:10.1152/ajpheart.00324.2003 [Abstract] [Full Text] [PDF]  

Kathryn G. Lamping, Lance P. Christensen, and Robert J. Tomanek

Estrogen therapy induces collateral and microvascular remodeling
Am J Physiol Heart Circ Physiol 285: 2039-2044, 2003. First published July 10, 2003; doi:10.1152/ajpheart.00405.2003 [Abstract] [Full Text] [PDF]  

H. L. Xu, R. A. Santizo, V. L. Baughman, and D. A. Pelligrino

Nascent EDHF-mediated cerebral vasodilation in ovariectomized rats is not induced by eNOS dysfunction
Am J Physiol Heart Circ Physiol 285: 2045-2053, 2003. First published July 17, 2003; doi:10.1152/ajpheart.00439.2003 [Abstract] [Full Text] [PDF]  

I. T. Udosen, H. Jiang, H. C. Hercule, and A. O. Oyekan

Nitric oxide-epoxygenase interactions and arachidonate-induced dilation of rat renal microvessels
Am J Physiol Heart Circ Physiol 285: 2054-2063, 2003. First published July 24, 2003; doi:10.1152/ajpheart.00075.2003 [Abstract] [Full Text] [PDF]  

Enrique Saldívar, Pedro Cabrales, Amy G. Tsai, and Marcos Intaglietta

Microcirculatory changes during chronic adaptation to hypoxia
Am J Physiol Heart Circ Physiol 285: 2064-2071, 2003; doi:10.1152/ajpheart.00349.2003 [Abstract] [Full Text] [PDF]  

Masaru Takahashi, Hirokazu Shiraishi, Yuji Ishibashi, Kristie L. Blade, Paul J. McDermott, Donald R. Menick, Dhandapani Kuppuswamy, and George Cooper, IV

Phenotypic consequences of ₁-tubulin expression and MAP4 decoration of microtubules in adult cardiocytes
Am J Physiol Heart Circ Physiol 285: 2072-2083, 2003. First published July 10, 2003; doi:10.1152/ajpheart.00396.2003 [Abstract] [Full Text] [PDF]  

Rainer Schulz, Stephanie Aker, Sergej Belosjorow, Ina Konietzka, Ursula Rauen, and Gerd Heusch

Stress kinase phosphorylation is increased in pacing-induced heart failure in rabbits
Am J Physiol Heart Circ Physiol 285: 2084-2090, 2003. First published July 3, 2003; doi:10.1152/ajpheart.01038.2002 [Abstract] [Full Text] [PDF]  

Hideki Hayashi, Chikaya Omichi, Yasushi Miyauchi, William J. Mandel, Shien-Fong Lin, Peng-Sheng Chen, and Hrayr S. Karagueuzian

Age-related sensitivity to nicotine for inducible atrial tachycardia and atrial fibrillation
Am J Physiol Heart Circ Physiol 285: 2091-2098, 2003; doi:10.1152/ajpheart.00371.2003 [Abstract] [Full Text] [PDF]  

Renee J. Filion and Christopher G. Ellis

A finite difference model of O₂ transport in aortic valve cusps: importance of intrinsic microcirculation
Am J Physiol Heart Circ Physiol 285: 2099-2104, 2003. First published July 17, 2003; doi:10.1152/ajpheart.00330.2003 [Abstract] [Full Text] [PDF]  

Jian Cui, Rong Zhang, Thad E. Wilson, Sarah Witkowski, Craig G. Crandall, and Benjamin D. Levine

Nitric oxide synthase inhibition does not affect regulation of muscle sympathetic nerve activity during head-up tilt
Am J Physiol Heart Circ Physiol 285: 2105-2110, 2003. First published July 3, 2003; doi:10.1152/ajpheart.01076.2002 [Abstract] [Full Text] [PDF]  

Jun Su, Shengjun Zhang, James Tse, Peter M. Scholz, and Harvey R. Weiss

Alterations in nitric oxide-cGMP pathway in ventricular myocytes from obese leptin-deficient mice
Am J Physiol Heart Circ Physiol 285: 2111-2117, 2003. First published July 17, 2003; doi:10.1152/ajpheart.00316.2003 [Abstract] [Full Text] [PDF]  

Russell C. Scaduto, Jr. and Lee W. Grotyohann

Hydrolysis of Ca²⁺-sensitive fluorescent probes by perfused rat heart
Am J Physiol Heart Circ Physiol 285: 2118-2124, 2003; doi:10.1152/ajpheart.00881.2001 [Abstract] [Full Text] [PDF]  

Noritoshi Nagaya, Hiroyuki Okumura, Masaaki Uematsu, Wataru Shimizu, Fumiaki Ono, Mikiyasu Shirai, Hidezo Mori, Kunio Miyatake, and Kenji Kangawa

Repeated inhalation of adrenomedullin ameliorates pulmonary hypertension and survival in monocrotaline rats
Am J Physiol Heart Circ Physiol 285: 2125-2131, 2003; doi:10.1152/ajpheart.00548.2002 [Abstract] [Full Text] [PDF]  

Pradeep P. A. Mammen, Shane B. Kanatous, Ivan S. Yuhanna, Philip W. Shaul, Mary G. Garry, Robert S. Balaban, and Daniel J. Garry

Hypoxia-induced left ventricular dysfunction in myoglobin-deficient mice
Am J Physiol Heart Circ Physiol 285: 2132-2141, 2003. First published July 24, 2003; doi:10.1152/ajpheart.00147.2003 [Abstract] [Full Text] [PDF]  

John W. Osborn, Pilar Ariza-Nieto, John P. Collister, Sandra Soucheray, Benjamin Zimmerman, and Stephen Katz

Responsiveness vs. basal activity of plasma ANG II as a determinant of arterial pressure salt sensitivity
Am J Physiol Heart Circ Physiol 285: 2142-2149, 2003. First published July 24, 2003; doi:10.1152/ajpheart.00200.2003 [Abstract] [Full Text] [PDF]  

Judy M. Muller-Delp, Dennis B. Lubahn, Kathryn E. Nichol, Brian J. Philips, Elmer M. Price, Edward M. Curran, and M. Harold Laughlin

Regulation of nitric oxide-dependent vasodilation in coronary arteries of estrogen receptor--deficient mice
Am J Physiol Heart Circ Physiol 285: 2150-2157, 2003. First published July 24, 2003; doi:10.1152/ajpheart.00966.2002 [Abstract] [Full Text] [PDF]  

Pablo F. Soto, Pilar Herrero, Andrew M. Kates, Carmen S. Dence, Ali A. Ehsani, Victor Dávila-Román, Kenneth B. Schechtman, and Robert J. Gropler

Impact of aging on myocardial metabolic response to dobutamine
Am J Physiol Heart Circ Physiol 285: 2158-2164, 2003. First published July 24, 2003; doi:10.1152/ajpheart.00086.2003 [Abstract] [Full Text] [PDF]  

Brett M. Mitchell, Anne M. Dorrance, and R. Clinton Webb

GTP cyclohydrolase 1 inhibition attenuates vasodilation and increases blood pressure in rats
Am J Physiol Heart Circ Physiol 285: 2165-2170, 2003. First published July 10, 2003; doi:10.1152/ajpheart.00253.2003 [Abstract] [Full Text] [PDF]  

Katare Gopalrao Rajesh, Shiro Sasaguri, Ryoko Suzuki, and Hironori Maeda

Antioxidant MCI-186 inhibits mitochondrial permeability transition pore and upregulates Bcl-2 expression
Am J Physiol Heart Circ Physiol 285: 2171-2178, 2003. First published June 19, 2003; doi:10.1152/ajpheart.00143.2003 [Abstract] [Full Text] [PDF]  

Xinhua Yan, Robert L. Price, Masaharu Nakayama, Kenta Ito, Adam J. T. Schuldt, Warren J. Manning, Atsushi Sanbe, Thomas K. Borg, Jeffrey Robbins, and Beverly H. Lorell

Ventricular-specific expression of angiotensin II type 2 receptors causes dilated cardiomyopathy and heart failure in transgenic mice
Am J Physiol Heart Circ Physiol 285: 2179-2187, 2003. First published July 17, 2003; doi:10.1152/ajpheart.00361.2003 [Abstract] [Full Text] [PDF]  

C. C. Liu, Terry B. J. Kuo, and Cheryl C. H. Yang

Effects of estrogen on gender-related autonomic differences in humans
Am J Physiol Heart Circ Physiol 285: 2188-2193, 2003. First published July 24, 2003; doi:10.1152/ajpheart.00256.2003 [Abstract] [Full Text] [PDF]  

Steven A. J. Chamuleau, Maria Siebes, Martijn Meuwissen, Karel T. Koch, Jos A. E. Spaan, and Jan J. Piek

Association between coronary lesion severity and distal microvascular resistance in patients with coronary artery disease
Am J Physiol Heart Circ Physiol 285: 2194-2200, 2003. First published June 26, 2003; doi:10.1152/ajpheart.01021.2002 [Abstract] [Full Text] [PDF]  

Janelle R. Keys, Emily A. Greene, Chris J. Cooper, Sathyamangla V. Naga Prasad, Howard A. Rockman, and Walter J. Koch

Cardiac hypertrophy and altered -adrenergic signaling in transgenic mice that express the amino terminus of -ARK1
Am J Physiol Heart Circ Physiol 285: 2201-2211, 2003. First published July 17, 2003; doi:10.1152/ajpheart.00112.2003 [Abstract] [Full Text] [PDF]  

Alexander Deten, Huntly Millar, and Heinz-Gerd Zimmer

Catheterization of pulmonary artery in rats with an ultraminiature catheter pressure transducer
Am J Physiol Heart Circ Physiol 285: 2212-2217, 2003. First published July 24, 2003; doi:10.1152/ajpheart.00315.2003 [Abstract] [Full Text] [PDF]  

R. Nijmeijer, M. Willemsen, C. J. L. M. Meijer, C. A. Visser, R. H. Verheijen, R. A. Gottlieb, C. E. Hack, and H. W. M. Niessen

Type II secretory phospholipase A₂ binds to ischemic flip-flopped cardiomyocytes and subsequently induces cell death
Am J Physiol Heart Circ Physiol 285: 2218-2224, 2003. First published June 12, 2003; doi:10.1152/ajpheart.00887.2002 [Abstract] [Full Text] [PDF]  

Adviye Ergul, Vera Portik-Dobos, Ararat D. Giulumian, Mariela M. Molero, and Leslie C. Fuchs

Stress upregulates arterial matrix metalloproteinase expression and activity via endothelin A receptor activation
Am J Physiol Heart Circ Physiol 285: 2225-2232, 2003. First published July 3, 2003; doi:10.1152/ajpheart.00133.2003 [Abstract] [Full Text] [PDF]  

INNOVATIVE METHODOLOGY:

Per Reidar Woldbaek, Tævje Andreas Strømme, Jørn Bodvar Sande, Geir Christensen, Theis Tønnessen, and Arnfinn Ilebekk

Evaluation of a new fiber-optic pressure recording system for cardiovascular measurements in mice
Am J Physiol Heart Circ Physiol 285: 2233-2239, 2003. First published June 26, 2003; doi:10.1152/ajpheart.01123.2002 [Abstract] [Full Text] [PDF]  

Elizabeth A. Nunamaker, Hai-Ying Zhang, Yuichi Shirasawa, Joseph N. Benoit, and David A. Dean

Electroporation-mediated delivery of catalytic oligodeoxynucleotides for manipulation of vascular gene expression
Am J Physiol Heart Circ Physiol 285: 2240-2247, 2003. First published July 24, 2003; doi:10.1152/ajpheart.00350.2003 [Abstract] [Full Text] [PDF]  

LETTERS TO THE EDITOR:

Boris Nohé, Tanja Johannes, Hans-Juergen Dieterich, Konstantin Mayer, Martina Merfels, Friedrich Grimminger, and Werner Seeger

Antiinflammatory effects of -3 fatty acids vary at different stages of inflammation
Am J Physiol Heart Circ Physiol 285: 2248-2250, 2003; doi:10.1152/ajpheart.01138.2002 [Full Text] [PDF]  

CORRIGENDA:

Errata for vol. 285, p. H1347
Am J Physiol Heart Circ Physiol 285: 2251-2251, 2003; doi:10.1152/ajpheart.00830.2003 [Full Text] [PDF]  

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