SPECIAL TOPICS:

William M. Chilian and David D. Gutterman

Prologue: new insights into the regulation of the coronary microcirculation
Am J Physiol Heart Circ Physiol 2000 279: H2585-H2586. [Full Text]  

SPECIAL MEDICAL EDITORIALS:

Gianmario Sambuceti, Antonio L'Abbate, and Mario Marzilli

Why should we study the coronary microcirculation?
Am J Physiol Heart Circ Physiol 2000 279: H2581-H2584. [Full Text]  

ARTICLES:

Hilmar Dörge, Till Neumann, Matthias Behrends, Andreas Skyschally, Rainer Schulz, Christoph Kasper, Raimund Erbel, and Gerd Heusch

Perfusion-contraction mismatch with coronary microvascular obstruction: role of inflammation
Am J Physiol Heart Circ Physiol 2000 279: H2587-H2592. [Abstract] [Full Text]  

Daphne Merkus, David W. Stepp, Deron W. Jones, Yasuhiro Nishikawa, and William M. Chilian

Adenosine preconditions against endothelin-induced constriction of coronary arterioles
Am J Physiol Heart Circ Physiol 2000 279: H2593-H2597. [Abstract] [Full Text]  

Shawn G. Clark and Leslie C. Fuchs

BK_Ca channels compensate for loss of NOS-dependent coronary artery relaxation in cardiomyopathy
Am J Physiol Heart Circ Physiol 2000 279: H2598-H2603. [Abstract] [Full Text]  

Jonathan E. Graves, Iain A. Greenwood, and William A. Large

Tonic regulation of vascular tone by nitric oxide and chloride ions in rat isolated small coronary arteries
Am J Physiol Heart Circ Physiol 2000 279: H2604-H2611. [Abstract] [Full Text]  

Cuihua Zhang, Travis W. Hein, and Lih Kuo

Transmural difference in coronary arteriolar dilation to adenosine: effect of luminal pressure and K_ATP channels
Am J Physiol Heart Circ Physiol 2000 279: H2612-H2619. [Abstract] [Full Text]  

Ken Terata, Hiroto Miura, Yanping Liu, Fausto Loberiza, and David D. Gutterman

Human coronary arteriolar dilation to adrenomedullin: role of nitric oxide and K⁺ channels
Am J Physiol Heart Circ Physiol 2000 279: H2620-H2626. [Abstract] [Full Text]  

Antonino Buffon, Stefano Rigattieri, Stefano A. Santini, Vito Ramazzotti, Filippo Crea, Bruno Giardina, and Attilio Maseri

Myocardial ischemia-reperfusion damage after pacing-induced tachycardia in patients with cardiac syndrome X
Am J Physiol Heart Circ Physiol 2000 279: H2627-H2633. [Abstract] [Full Text]  

Nicos Spyrou, Masood A. Khan, Stuart D. Rosen, Rodney Foale, D. Wyn Davies, Franco Sogliani, Rex De Lisle Stanbridge, and Paolo G. Camici

Persistent but reversible coronary microvascular dysfunction after bypass grafting
Am J Physiol Heart Circ Physiol 2000 279: H2634-H2640. [Abstract] [Full Text]  

Gianmario Sambuceti, Mario Marzilli, Andrea Mari, Cecilia Marini, Paolo Marzullo, Roberto Testa, Isabella Raugei, Micaela Papini, Mathis Schluter, and Antonio L'Abbate

Clinical evidence for myocardial derecruitment downstream from severe stenosis: pressure-flow control interaction
Am J Physiol Heart Circ Physiol 2000 279: H2641-H2648. [Abstract] [Full Text]  

Seema Mital, Xiaoping Zhang, Gong Zhao, Robert D. Bernstein, Carolyn J. Smith, David L. Fulton, William C. Sessa, James K. Liao, and Thomas H. Hintze

Simvastatin upregulates coronary vascular endothelial nitric oxide production in conscious dogs
Am J Physiol Heart Circ Physiol 2000 279: H2649-H2657. [Abstract] [Full Text]  

Keli Hu, Daria Mochly-Rosen, and Mohamed Boutjdir

Evidence for functional role of PKC isozyme in the regulation of cardiac Ca²⁺ channels
Am J Physiol Heart Circ Physiol 2000 279: H2658-H2664. [Abstract] [Full Text]  

Marcus L. Koller, Mark L. Riccio, and Robert F. Gilmour Jr

Effects of [K⁺]_o on electrical restitution and activation dynamics during ventricular fibrillation
Am J Physiol Heart Circ Physiol 2000 279: H2665-H2672. [Abstract] [Full Text]  

Sharon L. Hale and Robert A. Kloner

Effect of combined K_ATP channel activation and Na⁺/H⁺ exchange inhibition on infarct size in rabbits
Am J Physiol Heart Circ Physiol 2000 279: H2673-H2677. [Abstract] [Full Text]  

William M. Armstead

NOC/oFQ PKC-dependent superoxide generation contributes to hypoxic-ischemic impairment of NMDA cerebrovasodilation
Am J Physiol Heart Circ Physiol 2000 279: H2678-H2684. [Abstract] [Full Text]  

J. William Lester and Polly A. Hofmann

Role for PKC in the adenosine-induced decrease in shortening velocity of rat ventricular myocytes
Am J Physiol Heart Circ Physiol 2000 279: H2685-H2693. [Abstract] [Full Text]  

Yoshiya Toyoda, Ingeborg Friehs, Robert A. Parker, Sidney Levitsky, and James D. McCully

Differential role of sarcolemmal and mitochondrial K_ATP channels in adenosine-enhanced ischemic preconditioning
Am J Physiol Heart Circ Physiol 2000 279: H2694-H2703. [Abstract] [Full Text]  

Sophocles Chrissobolis, James Ziogas, Yi Chu, Frank M. Faraci, and Christopher G. Sobey

Role of inwardly rectifying K⁺ channels in K⁺-induced cerebral vasodilatation in vivo
Am J Physiol Heart Circ Physiol 2000 279: H2704-H2712. [Abstract] [Full Text]  

Hiroshi Endoh, Takaho Kaneko, Hiro Nakamura, Katsuhiko Doi, and Eiji Takahashi

Improved cardiac contractile functions in hypoxia-reoxygenation in rats treated with low concentration Co²⁺
Am J Physiol Heart Circ Physiol 2000 279: H2713-H2719. [Abstract] [Full Text]  

Åsa Ringqvist, Kenneth Caidahl, Ann-Sofi Petersson, and Åke Wennmalm

Diurnal variation of flow-mediated vasodilation in healthy premenopausal women
Am J Physiol Heart Circ Physiol 2000 279: H2720-H2725. [Abstract] [Full Text]  

Xiao-Yu Zhang, Jason Luck, Mark W. Dewhirst, and Fan Yuan

Interstitial hydraulic conductivity in a fibrosarcoma
Am J Physiol Heart Circ Physiol 2000 279: H2726-H2734. [Abstract] [Full Text]  

Pamela J. White, Rajendra Kumari, Karen E. Porter, Nicholas J. M. London, Leong L. Ng, and Michael R. Boarder

Antiproliferative effect of UTP on human arterial and venous smooth muscle cells
Am J Physiol Heart Circ Physiol 2000 279: H2735-H2742. [Abstract] [Full Text]  

Andrei L. Kleschyov, Bernard Muller, Thérèse Keravis, Marie-Elisabeth Stoeckel, and Jean-Claude Stoclet

Adventitia-derived nitric oxide in rat aortas exposed to endotoxin: cell origin and functional consequences
Am J Physiol Heart Circ Physiol 2000 279: H2743-H2751. [Abstract] [Full Text]  

Amanda Lochner, Erna Marais, Sonia Genade, and Johan A. Moolman

Nitric oxide: a trigger for classic preconditioning?
Am J Physiol Heart Circ Physiol 2000 279: H2752-H2765. [Abstract] [Full Text]  

Peiyong Zhai, Thomas E. Eurell, Robert Cotthaus, Elizabeth H. Jeffery, Janice M. Bahr, and David R. Gross

Effect of estrogen on global myocardial ischemia-reperfusion injury in female rats
Am J Physiol Heart Circ Physiol 2000 279: H2766-H2775. [Abstract] [Full Text]  

J. Wang, A. Seth, and C. A. G. McCulloch

Force regulates smooth muscle actin in cardiac fibroblasts
Am J Physiol Heart Circ Physiol 2000 279: H2776-H2785. [Abstract] [Full Text]  

Shaohua Ye, Pantea Mozayeni, Michael Gamburd, Huiqin Zhong, and Vito M. Campese

Interleukin-1 and neurogenic control of blood pressure in normal rats and rats with chronic renal failure
Am J Physiol Heart Circ Physiol 2000 279: H2786-H2796. [Abstract] [Full Text]  

Wendell S. Akers, Andrew Cross, Robert Speth, Linda P. Dwoskin, and Lisa A. Cassis

Renin-angiotensin system and sympathetic nervous system in cardiac pressure-overload hypertrophy
Am J Physiol Heart Circ Physiol 2000 279: H2797-H2806. [Abstract] [Full Text]  

William E. Schutzer, Hong Xue, John F. Reed, Jean-Baptiste Roullet, Sharon Anderson, and Scott L. Mader

Angiotensin II enhances -adrenergic receptor-mediated vasorelaxation in aortas from young but not old rats
Am J Physiol Heart Circ Physiol 2000 279: H2807-H2814. [Abstract] [Full Text]  

Charmaine B. S. Henry and Brian R. Duling

TNF- increases entry of macromolecules into luminal endothelial cell glycocalyx
Am J Physiol Heart Circ Physiol 2000 279: H2815-H2823. [Abstract] [Full Text]  

Michaela R. Hoffmeyer, Rosario Scalia, Chris R. Ross, Steven P. Jones, and David J. Lefer

PR-39, a potent neutrophil inhibitor, attenuates myocardial ischemia-reperfusion injury in mice
Am J Physiol Heart Circ Physiol 2000 279: H2824-H2828. [Abstract] [Full Text]  

Christelle D. Douillet, Victoria Velarde, Julie T. Christopher, Ronald K. Mayfield, Maria E. Trojanowska, and Ayad A. Jaffa

Mechanisms by which bradykinin promotes fibrosis in vascular smooth muscle cells: role of TGF- and MAPK
Am J Physiol Heart Circ Physiol 2000 279: H2829-H2837. [Abstract] [Full Text]  

Tsung-Ming Lee, Sheng-Fang Su, Wen-Yi Suo, Chen-Yueh Lee, Ming-Fong Chen, Yuan-Teh Lee, and Chang-Her Tsai

Distension of urinary bladder induces exaggerated coronary constriction in smokers with early atherosclerosis
Am J Physiol Heart Circ Physiol 2000 279: H2838-H2845. [Abstract] [Full Text]  

Thomas G. Hampton, Ju-Feng Wang, Joseph DeAngelis, Ivo Amende, Kenneth D. Philipson, and James P. Morgan

Enhanced gene expression of Na⁺/Ca²⁺ exchanger attenuates ischemic and hypoxic contractile dysfunction
Am J Physiol Heart Circ Physiol 2000 279: H2846-H2854. [Abstract] [Full Text]  

Akio Saeki, Yoichi Goto, Katsuya Hata, Toshiyuki Takasago, Takehiko Nishioka, and Hiroyuki Suga

Negative inotropism of hyperthermia increases oxygen cost of contractility in canine hearts
Am J Physiol Heart Circ Physiol 2000 279: H2855-H2864. [Abstract] [Full Text]  

Cornelia Haug, Alexandra Schmid-Kotsas, Ulrike Zorn, Max G. Bachem, Sabine Schuett, Adolf Gruenert, and Eva Rozdzinski

Hepatocyte growth factor is upregulated by low-density lipoproteins and inhibits endothelin-1 release
Am J Physiol Heart Circ Physiol 2000 279: H2865-H2871. [Abstract] [Full Text]  

John T. Barron, Liping Gu, and Joseph E. Parrillo

NADH/NAD redox state of cytoplasmic glycolytic compartments in vascular smooth muscle
Am J Physiol Heart Circ Physiol 2000 279: H2872-H2878. [Abstract] [Full Text]  

Jin Fu Wen, Xun Cui, Jin Sub Ahn, Suhn Hee Kim, Kyung Hwan Seul, Sung Zoo Kim, Young Kyung Park, Ho Sub Lee, and Kyung Woo Cho

Distinct roles for L- and T-type Ca²⁺ channels in regulation of atrial ANP release
Am J Physiol Heart Circ Physiol 2000 279: H2879-H2888. [Abstract] [Full Text]  

Stefan W. Ryter, Minliang Si, Chen-Ching Lai, and Ching-Yuan Su

Regulation of endothelial heme oxygenase activity during hypoxia is dependent on chelatable iron
Am J Physiol Heart Circ Physiol 2000 279: H2889-H2897. [Abstract] [Full Text]  

Zhi-Wei Yang, Jun Wang, Tao Zheng, Bella T. Altura, and Burton M. Altura

Low [Mg²⁺]_o induces contraction and [Ca²⁺]_i rises in cerebral arteries: roles of Ca²⁺, PKC, and PI3
Am J Physiol Heart Circ Physiol 2000 279: H2898-H2907. [Abstract] [Full Text]  

Theresa L. O'Donaughy and Benjimen R. Walker

Renal vasodilatory influence of endogenous carbon monoxide in chronically hypoxic rats
Am J Physiol Heart Circ Physiol 2000 279: H2908-H2915. [Abstract] [Full Text]  

Can G. Pham, Alice E. Harpf, Rebecca S. Keller, Hoa T. Vu, Shaw-Yung Shai, Joseph C. Loftus, and Robert S. Ross

Striated muscle-specific _1D-integrin and FAK are involved in cardiac myocyte hypertrophic response pathway
Am J Physiol Heart Circ Physiol 2000 279: H2916-H2926. [Abstract] [Full Text]  

G. S. Aldea, H. Mori, W. K. Husseini, R. E. Austin, and J. I. E. Hoffman

Effects of increased pressure inside or outside ventricles on total and regional myocardial blood flow
Am J Physiol Heart Circ Physiol 2000 279: H2927-H2938. [Abstract] [Full Text]  

Hiroshi Yamakawa, Takuroh Imamura, Takeshi Matsuo, Hisamitsu Onitsuka, Yoko Tsumori, Johji Kato, Kazuo Kitamura, Yasushi Koiwaya, and Tanenao Eto

Diastolic wall stress and ANG II in cardiac hypertrophy and gene expression induced by volume overload
Am J Physiol Heart Circ Physiol 2000 279: H2939-H2946. [Abstract] [Full Text]  

John T. Berg, Steven Deem, Mark E. Kerr, and Erik R. Swenson

Hemoglobin and red blood cells alter the response of expired nitric oxide to mechanical forces
Am J Physiol Heart Circ Physiol 2000 279: H2947-H2953. [Abstract] [Full Text]  

Tatsushi Suwa, James C. Hogg, Dean English, and Stephan F. Van Eeden

Interleukin-6 induces demargination of intravascular neutrophils and shortens their transit in marrow
Am J Physiol Heart Circ Physiol 2000 279: H2954-H2960. [Abstract] [Full Text]  

Satoru Ito and Alan F. Sved

Pharmacological profile of depressor response elicited by sarthran in rat ventrolateral medulla
Am J Physiol Heart Circ Physiol 2000 279: H2961-H2966. [Abstract] [Full Text]  

Raymond K. Kudej, Xiao-Ping Zhang, Bijan Ghaleh, Cheng-Hsuing Huang, John B. Jackson, Amelia B. Kudej, Naoki Sato, Shoko Sato, Dorothy E. Vatner, Thomas H. Hintze, and Stephen F. Vatner

Enhanced cAMP-induced nitric oxide-dependent coronary dilation during myocardial stunning in conscious pigs
Am J Physiol Heart Circ Physiol 2000 279: H2967-H2974. [Abstract] [Full Text]  

Kun Don Yi, H. Fred Downey, Xiaoming Bian, Min Fu, and Robert T. Mallet

Dobutamine enhances both contractile function and energy reserves in hypoperfused canine right ventricle
Am J Physiol Heart Circ Physiol 2000 279: H2975-H2985. [Abstract] [Full Text]  

Jianhua Li and Jere H. Mitchell

c-Fos expression in the midbrain periaqueductal gray during static muscle contraction
Am J Physiol Heart Circ Physiol 2000 279: H2986-H2993. [Abstract] [Full Text]  

Hongkui Jin, Renhui Yang, Wei Li, Hsienwie Lu, Anne M. Ryan, Annie K. Ogasawara, John Van Peborgh, and Nicholas F. Paoni

Effects of exercise training on cardiac function, gene expression, and apoptosis in rats
Am J Physiol Heart Circ Physiol 2000 279: H2994-H3002. [Abstract] [Full Text]  

Laura Bianchi, Silvia G. Priori, Carlo Napolitano, Krystyna A. Surewicz, Adrienne T. Dennis, Mirella Memmi, Peter J. Schwartz, and Arthur M. Brown

Mechanisms of I_Ks suppression in LQT1 mutants
Am J Physiol Heart Circ Physiol 2000 279: H3003-H3011. [Abstract] [Full Text]  

Hiroya Kawai, Suzanne Y. Stevens, and Chang-Seng Liang

Renin-angiotensin system inhibition on noradrenergic nerve terminal function in pacing-induced heart failure
Am J Physiol Heart Circ Physiol 2000 279: H3012-H3019. [Abstract] [Full Text]  

Jianming Hao, Baiqiu Wang, Stephen C. Jones, Davinder S. Jassal, and Ian M. C. Dixon

Interaction between angiotensin II and Smad proteins in fibroblasts in failing heart and in vitro
Am J Physiol Heart Circ Physiol 2000 279: H3020-H3030. [Abstract] [Full Text]  

Toshio Nishikimi, Atsuro Miyata, Takeshi Horio, Fumiki Yoshihara, Noritoshi Nagaya, Shuichi Takishita, Chikao Yutani, Hisayuki Matsuo, Hiroaki Matsuoka, and Kenji Kangawa

Urocortin, a member of the corticotropin-releasing factor family, in normal and diseased heart
Am J Physiol Heart Circ Physiol 2000 279: H3031-H3039. [Abstract] [Full Text]  

Julián J. González, Juan J. Cordero, Manuel Feria, and Ernesto Pereda

Detection and sources of nonlinearity in the variability of cardiac R-R intervals and blood pressure in rats
Am J Physiol Heart Circ Physiol 2000 279: H3040-H3046. [Abstract] [Full Text]  

Stephen H. Bennett, Marlowe W. Eldridge, Daniel Zaghi, Shaaron E. Zaghi, Jay M. Milstein, and Boyd W. Goetzman

Form and function of fetal and neonatal pulmonary arterial bifurcations
Am J Physiol Heart Circ Physiol 2000 279: H3047-H3057. [Abstract] [Full Text]  

Jian-Ping Bin, Robert A. Pelberg, Kevin Wei, Matthew Coggins, N. Craig Goodman, and Sanjiv Kaul

Relation between regional function and coronary blood flow reserve in multivessel coronary artery stenosis
Am J Physiol Heart Circ Physiol 2000 279: H3058-H3064. [Abstract] [Full Text]  

Pierre Zoldhelyi, Pamela J. Beck, Robert J. Bjercke, Judy C. Ober, X. Hu, Janice M. McNatt, Salman Akhtar, Mohammed Ahmed, Fred J. Clubb Jr., Zhi-Qiang Chen, Richard A. F. Dixon, Edward T. H. Yeh, and James T. Willerson

Inhibition of coronary thrombosis and local inflammation by a noncarbohydrate selectin inhibitor
Am J Physiol Heart Circ Physiol 2000 279: H3065-H3075. [Abstract] [Full Text]  

Sylvia O. Suadicani, Monique J. Vink, and David C. Spray

Slow intercellular Ca²⁺ signaling in wild-type and Cx43-null neonatal mouse cardiac myocytes
Am J Physiol Heart Circ Physiol 2000 279: H3076-H3088. [Abstract] [Full Text]  

Simon W. Rabkin and Jennifer Y Kong

Nitroprusside induces cardiomyocyte death: interaction with hydrogen peroxide
Am J Physiol Heart Circ Physiol 2000 279: H3089-H3100. [Abstract] [Full Text]  

SPECIAL COMMUNICATIONS:

Giovanni Esposito, L. F. Santana, Keith Dilly, Jader Dos Santos Cruz, Lan Mao, W. J. Lederer, and Howard A. Rockman

Cellular and functional defects in a mouse model of heart failure
Am J Physiol Heart Circ Physiol 2000 279: H3101-H3112. [Abstract] [Full Text]  

Chikaya Omichi, Moon-Hyoung Lee, Toshihiko Ohara, Ajay M. Naik, Nina C. Wang, Hrayr S. Karagueuzian, and Peng-Sheng Chen

Comparing cardiac action potentials recorded with metal and glass microelectrodes
Am J Physiol Heart Circ Physiol 2000 279: H3113-H3117. [Abstract] [Full Text]  

Lori A. Gustafson and Johannes H. G. M. Van Beek

Measurement of the activation time of oxidative phosphorylation in isolated mouse hearts
Am J Physiol Heart Circ Physiol 2000 279: H3118-H3123. [Abstract] [Full Text]  

Michael J. Yost, David Simpson, Kimberly Wrona, Stephen Ridley, Harry J. Ploehn, Thomas K. Borg, and Louis Terracio

Design and construction of a uniaxial cell stretcher
Am J Physiol Heart Circ Physiol 2000 279: H3124-H3130. [Abstract] [Full Text]  

Janet K. Bailey, Casey A. Kindig, Brad J. Behnke, Timothy I. Musch, Geert W. Schmid-Schoenbein, and David C. Poole

Spinotrapezius muscle microcirculatory function: effects of surgical exteriorization
Am J Physiol Heart Circ Physiol 2000 279: H3131-H3137. [Abstract] [Full Text]  

RAPID COMMUNICATION:

Hong Kan, Zirong Xie, and Mitchell S. Finkel

HIV gp120 enhances NO production by cardiac myocytes through p38 MAP kinase-mediated NF-B activation
Am J Physiol Heart Circ Physiol 2000 279: H3138-H3143. [Abstract] [Full Text]  

LETTERS TO THE EDITOR:

R. S. Richardson

Complementary studies of exercised-induced angiogenic growth factors in human skeletal muscle
Am J Physiol Heart Circ Physiol 2000 279: H3144-H3145. [Full Text]  

T. Gustafsson and C. J. Sundberg

Expression of angiogenic growth factors in human skeletal muscle in response to a singular bout of exercise
Am J Physiol Heart Circ Physiol 2000 279: H3146. [Full Text]  

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