AJP - Heart and Circulatory Physiology, Vol 250, Issue 6 1145-H1149, Copyright © 1986 by American Physiological Society

ARTICLES

Flow-induced release of endothelium-derived relaxing factor

G. M. Rubanyi, J. C. Romero and P. M. Vanhoutte

To analyze the potential mediator(s) involved in flow-induced endothelium-dependent vasodilation, we measured the wall tension of intraluminally perfused canine femoral artery segments and compared the content of 6-ketoprostaglandin F1 alpha (determined by radioimmunoassay) and the relaxing activity of the effluent (determined by bioassay on canine coronary artery rings). During perfusion at a steady flow of 2 ml/min the effluent contained 6-keto-prostaglandin F1 alpha and relaxed the bioassay rings. Sudden increase in steady flow rate to 4 ml/min, or the introduction of pulsatile flow, increased the release of 6-keto-prostaglandin F1 alpha and induced further relaxations of the bioassay ring. No relaxations were observed with the effluent passing through a femoral artery segment without endothelium. Indomethacin significantly depressed the release of 6-keto-prostaglandin F1 alpha during increases in flow but had no significant effect on the relaxing activity of the effluent. In the presence of indomethacin, increases in flow produced significant relaxation in the perfused femoral artery segments with endothelium. Superoxide dismutase restored the relaxing activity of the effluent during increases in flow at a transit time of 30 seconds. These data demonstrate that in addition to prostacyclin, flow triggers the release of another relaxing substance (or substances) from vascular endothelial cells that has characteristics similar to the endothelium-derived relaxing factor released by acetylcholine.

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				V. Rizzo, D. P. McIntosh, P. Oh, and J. E. Schnitzer In Situ Flow Activates Endothelial Nitric Oxide Synthase in Luminal Caveolae of Endothelium with Rapid Caveolin Dissociation and Calmodulin Association J. Biol. Chem., December 25, 1998; 273(52): 34724 - 34729. [Abstract] [Full Text] [PDF]

				R. Hambrecht, E. Fiehn, C. Weigl, S. Gielen, C. Hamann, R. Kaiser, J. Yu, V. Adams, J. Niebauer, and G. Schuler Regular Physical Exercise Corrects Endothelial Dysfunction and Improves Exercise Capacity in Patients With Chronic Heart Failure Circulation, December 15, 1998; 98(24): 2709 - 2715. [Abstract] [Full Text] [PDF]

				G. D. Thomas, M. Sander, K. S. Lau, P. L. Huang, J. T. Stull, and R. G. Victor Impaired metabolic modulation of alpha -adrenergic vasoconstriction in dystrophin-deficient skeletal muscle PNAS, December 8, 1998; 95(25): 15090 - 15095. [Abstract] [Full Text] [PDF]

				C. Stefanadis, J. Dernellis, E. Tsiamis, C. Stratos, I. Kallikazaros, and P. Toutouzas AORTIC FUNCTION IN PATIENTS DURING INTRA-AORTIC BALLOON PUMPING DETERMINED BY THE PRESSURE-DIAMETER RELATION J. Thorac. Cardiovasc. Surg., December 1, 1998; 116(6): 1052 - 1059. [Abstract] [Full Text] [PDF]

				H. J. Granger Cardiovascular physiology in the twentieth century: great strides and missed opportunities Am J Physiol Heart Circ Physiol, December 1, 1998; 275(6): H1925 - H1936. [Abstract] [Full Text] [PDF]

				J. B. Buckwalter, S. B. Ruble, P. J. Mueller, and P. S. Clifford Skeletal muscle vasodilation at the onset of exercise J Appl Physiol, November 1, 1998; 85(5): 1649 - 1654. [Abstract] [Full Text] [PDF]

				S. M. Black, J. R. Fineman, R. H. Steinhorn, J. Bristow, and S. J. Soifer Increased endothelial NOS in lambs with increased pulmonary blood flow and pulmonary hypertension Am J Physiol Heart Circ Physiol, November 1, 1998; 275(5): H1643 - H1651. [Abstract] [Full Text] [PDF]

				T. Minamino, M. Kitakaze, S. Sanada, H. Asanuama, T. Kurotobi, Y. Koretsune, M. Fukunami, T. Kuzuya, N. Hoki, and M. Hori Increased Expression of P-Selectin on Platelets Is a Risk Factor for Silent Cerebral Infarction in Patients With Atrial Fibrillation : Role of Nitric Oxide Circulation, October 27, 1998; 98(17): 1721 - 1727. [Abstract] [Full Text] [PDF]

				J. A. Rapps, P. R. Myers, Q. Zhong, and J. L. Parker Development of Endothelium-Dependent Relaxation in Canine Coronary Collateral Arteries Circulation, October 20, 1998; 98(16): 1675 - 1683. [Abstract] [Full Text] [PDF]

				G. S. Huggins, R. C. Pasternak, N. M. Alpert, A. J. Fischman, and H. Gewirtz Effects of Short-Term Treatment of Hyperlipidemia on Coronary Vasodilator Function and Myocardial Perfusion in Regions Having Substantial Impairment of Baseline Dilator Reverse Circulation, September 29, 1998; 98(13): 1291 - 1296. [Abstract] [Full Text] [PDF]

				S. Shastry, N. M. Dietz, J. R. Halliwill, A. S. Reed, and M. J. Joyner Effects of nitric oxide synthase inhibition on cutaneous vasodilation during body heating in humans J Appl Physiol, September 1, 1998; 85(3): 830 - 834. [Abstract] [Full Text] [PDF]

				C. Vedrinne, F. Tronc, S. Martinot, J. Robin, C. Garhib, J. Ninet, J. J. Lehot, M. Franck, and G. Champsaur Effects of various flow types on maternal hemodynamics during fetalbypass: Is there nitric oxide release during pulsatile perfusion? J. Thorac. Cardiovasc. Surg., September 1, 1998; 116(3): 432 - 436. [Abstract] [Full Text]

				W.-C. Huang and R.-Y. Tsai Nitric Oxide Synthesis Inhibition Retards Surgical Reversal of One-Kidney Goldblatt Hypertension in Rats Hypertension, September 1, 1998; 32(3): 534 - 540. [Abstract] [Full Text] [PDF]

				V. L. Morgan, T. P. Graham Jr., R. J. Roselli, and C. H. Lorenz Alterations in pulmonary artery flow patterns and shear stress determined with three-dimensional phase-contrast magnetic resonance imaging in fontan patients J. Thorac. Cardiovasc. Surg., August 1, 1998; 116(2): 294 - 304. [Abstract] [Full Text] [PDF]

				R. O. Cannon III Role of nitric oxide in cardiovascular disease: focus on the endothelium Clin. Chem., August 1, 1998; 44(8): 1809 - 1819. [Abstract] [Full Text] [PDF]