Objective of this study was to investigate the synchronization between low frequency breathing patterns and respiratory sinus arrhythmia (RSA) of heart rate during guided recitation of poetry, i.e. recitation of hexameter verse from ancient Greek literature performed in a therapeutic setting. 20 healthy volunteers performed three different types of exercises with respect to a cross-sectional comparison: recitation of hexameter verse, controlled breathing and spontaneous breathing. Each exercise was divided into three successive measurements: a 15-minute baseline measurement (S1), 20 minutes of exercise and a 15-minute effect measurement (S2). Breathing patterns and RSA were derived from respiratory traces and electrocardiograms, respectively, which were recorded simultaneously using an ambulatory device. The synchronization was then quantified by the index which has been adopted from the analysis of weakly coupled chaotic oscillators. During recitation of hexameter verse was high, indicating prominent cardiorespiratory synchronization. The controlled breathing exercise showed cardiorespiratory synchronization to a lesser extent and all resting periods (S1 and S2) had even fewer cardiorespiratory synchronization. During spontaneous breathing cardiorespiratory synchronization was minimal and hardly observable. The results were largely determined by the extent of a low frequency component in the breathing oscillations that emerged from the design of hexameter recitation. In conclusion, recitation of hexameter verse exerts a strong influence on RSA by a prominent low frequency component in the breathing pattern, generating a strong cardiorespiratory synchronization.