| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Center for Perinatal Biology, Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA, USA
* To whom correspondence should be addressed. E-mail: lzhang{at}som.llu.edu.
Fetal programming has profound effects on cardiovascular function in later adult life. We tested the hypothesis that chronic hypoxic exposure during fetal development down-regulates endogenous cardioprotective mechanisms in adult rats. Time-dated pregnant rats were divided between normoxic and hypoxic (10.5% O2 from day 15 to 21 of gestation) groups. The male progeny were studied at 2 months of age. Rats were subjected to heat stress (42 °C for 15 min). After 24 h, hearts were excised and subjected to 30 min of global ischemia and 1 h of reperfusion. Prenatal hypoxia did not change adult rat body weight and heart weight, but significantly increased cross-section area of left ventricular (LV) myocyte. Heat stress
significantly improved postischemic recovery of LV function in normoxic control rats, but not in prenatally hypoxic rats. The infarct size in left ventricle resulting from ischemia-reperfusion was reduced by the heat stress pretreatment in control rats, but not in prenatally hypoxic rats. In accordance, heat stress significantly increased LV myocardial content of heat shock protein 70 (HSP70) only in normoxic control rats. In addition, there was a significant decrease in LV myocardial content of protein kina se C 
isoform in prenatally hypoxic rats, compared with control rats. We conclude that prenatal hypoxia causes in utero programming of hsp70 gene in left ventricle, leading to an inhibition of its response to heat stress and a loss of cardioprotection in later adult life.
This article has been cited by other articles:
|
|
 |
|
  D. Xiao, Z. Xu, X. Huang, L. D. Longo, S. Yang, and L. Zhang Prenatal Gender-Related Nicotine Exposure Increases Blood Pressure Response to Angiotensin II in Adult Offspring Hypertension, April 1, 2008; 51(4): 1239 - 1247. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Meyer and Lubo Zhang Fetal Programming of Cardiac Function and Disease Reproductive Sciences, April 1, 2007; 14(3): 209 - 216. [Abstract] [PDF]
|
|
|
|
 |
|
 S. S. Jonker, L. Zhang, S. Louey, G. D. Giraud, K. L. Thornburg, and J. J. Faber Myocyte enlargement, differentiation, and proliferation kinetics in the fetal sheep heart J Appl Physiol, March 1, 2007; 102(3): 1130 - 1142. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Fernandez-Twinn, S. Ekizoglou, A. Wayman, C. J. Petry, and S. E. Ozanne Maternal low-protein diet programs cardiac beta-adrenergic response and signaling in 3-mo-old male offspring Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2006; 291(2): R429 - R436. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bae, R. D. Gilbert, C. A. Ducsay, and L. Zhang Prenatal cocaine exposure increases heart susceptibility to ischaemia-reperfusion injury in adult male but not female rats J. Physiol., May 15, 2005; 565(1): 149 - 158. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
