AJP - Heart Calcium Transients and Cell-Sarcomere
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol (May 22, 2003). doi:10.1152/ajpheart.00889.2002
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
285/3/H946    most recent
00889.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chen, J.
Right arrow Articles by Yu, X.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chen, J.
Right arrow Articles by Yu, X.
Submitted on October 16, 2002
Accepted on May 14, 2003

Remodeling of Cardiac Fiber Structure after Infarction in Rat Quantified with Diffusion Tensor MRI

Junjie Chen1, Sheng-Kwei Song2, Wei Liu1, Mark McLean3, Stacy J. Allen3, Jie Tan3, Samuel A. Wickline3, and Xin Yu3*

1 Department of Medicine, Washington University, St. Louis, MO, USA; Department of Biomedical Engineering, Washington University, St. Louis, MO, USA
2 Department of Chemistry and Radiology, Washington University, St. Louis, MO, USA
3 Department of Medicine, Washington University, St. Louis, MO, USA

* To whom correspondence should be addressed. E-mail: xin{at}cvu.wustl.edu.

Structural remodeling of myocardium after infarction plays a critical role in functional adaptation. Diffusion tensor MRI (DTMRI) provides a means for rapid and nondestructive characterization of the three-dimensional fiber architecture of cardiac tissues. In this study, microscopic structural changes caused by myocardial infarction were evaluated in Fischer 344 rats 4 weeks after infarct surgery. DTMRI studies were performed on 15 excised, formalin-fixed rat hearts of both infarct (LAD occlusion, n=8) and control (sham, n=7). Infarct myocardium exhibited increased water diffusivity (41% increase in trace values), and decreased diffusion anisotropy (37% decrease in relative anisotropy index). The reduced diffusion anisotropy correlated negatively with microscopic fiber disarray determined by histologic analysis (R=0.81). Transmural courses of fiber orientation angles in infarct zones were similar to those of normal myocardium. However, regional angular deviation of the diffusion tensor increased significantly in infarct myocardium, and correlated strongly with microscopic fiber disarray (R=0.86). These results suggest that DTMRI may provide a valuable tool for defining structural remodeling in diseased myocardium at the cellular and tissue level.




This article has been cited by other articles:


Home page
 J. Thorac. Cardiovasc. Surg.Home page
G. Buckberg, A. Mahajan, S. Saleh, J. I.E. Hoffman, and C. Coghlan
Structure and function relationships of the helical ventricular myocardial band
J. Thorac. Cardiovasc. Surg., September 1, 2008; 136(3): 578 - 589.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. J. Pope, G. B. Sands, B. H. Smaill, and I. J. LeGrice
Three-dimensional transmural organization of perimysial collagen in the heart
Am J Physiol Heart Circ Physiol, September 1, 2008; 295(3): H1243 - H1252.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J. W. Covell
Tissue Structure and Ventricular Wall Mechanics
Circulation, August 12, 2008; 118(7): 699 - 701.
[Full Text] [PDF]

Home page
 CirculationHome page
A. Cheng, T. C. Nguyen, M. Malinowski, G. T. Daughters, D. C. Miller, and N. B. Ingels Jr
Heterogeneity of Left Ventricular Wall Thickening Mechanisms
Circulation, August 12, 2008; 118(7): 713 - 721.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
C. M. Ripplinger, W. Li, J. Hadley, J. Chen, F. Rothenberg, R. Lombardi, S. A. Wickline, A. J. Marian, and I. R. Efimov
Enhanced Transmural Fiber Rotation and Connexin 43 Heterogeneity Are Associated With an Increased Upper Limit of Vulnerability in a Transgenic Rabbit Model of Human Hypertrophic Cardiomyopathy
Circ. Res., November 9, 2007; 101(10): 1049 - 1057.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Y. Jiang, J. M. Guccione, M. B. Ratcliffe, and E. W. Hsu
Transmural heterogeneity of diffusion anisotropy in the sheep myocardium characterized by MR diffusion tensor imaging
Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2377 - H2384.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
S. H. Gilbert, A. P. Benson, P. Li, and A. V. Holden
Regional localisation of left ventricular sheet structure: integration with current models of cardiac fibre, sheet and band structure
Eur. J. Cardiothorac. Surg., August 1, 2007; 32(2): 231 - 249.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
W. Liu, M. W. Ashford, J. Chen, M. P. Watkins, T. A. Williams, S. A. Wickline, and X. Yu
MR tagging demonstrates quantitative differences in regional ventricular wall motion in mice, rats, and men
Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2515 - H2521.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
C. Jackowski, A. Christe, M. Sonnenschein, E. Aghayev, and M. J. Thali
Postmortem unenhanced magnetic resonance imaging of myocardial infarction in correlation to histological infarction age characterization
Eur. Heart J., October 2, 2006; 27(20): 2459 - 2467.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
M.-T. Wu, W.-Y. I. Tseng, M.-Y. M. Su, C.-P. Liu, K.-R. Chiou, V. J. Wedeen, T. G. Reese, and C.-F. Yang
Diffusion Tensor Magnetic Resonance Imaging Mapping the Fiber Architecture Remodeling in Human Myocardium After Infarction: Correlation With Viability and Wall Motion
Circulation, September 5, 2006; 114(10): 1036 - 1045.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
R. M. K. Yu, C. C. Lin, P. K. Chan, E. S. H. Chow, M. B. Murphy, B. P. Chan, F. Muller, U. Strahle, and S. H. Cheng
Four-Dimensional Imaging and Quantification of Gene Expression in Early Developing Zebrafish (Danio rerio) Embryos
Toxicol. Sci., April 1, 2006; 90(2): 529 - 538.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. Chen, W. Liu, H. Zhang, L. Lacy, X. Yang, S.-K. Song, S. A. Wickline, and X. Yu
Regional ventricular wall thickening reflects changes in cardiac fiber and sheet structure during contraction: quantification with diffusion tensor MRI
Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H1898 - H1907.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
G. D. Buckberg
Editorial comment: New technology and old responsibilities
Eur. J. Cardiothorac. Surg., March 1, 2005; 27(3): 472 - 474.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
K. B. Harrington, F. Rodriguez, A. Cheng, F. Langer, H. Ashikaga, G. T. Daughters, J. C. Criscione, N. B. Ingels, and D. C. Miller
Direct measurement of transmural laminar architecture in the anterolateral wall of the ovine left ventricle: new implications for wall thickening mechanics
Am J Physiol Heart Circ Physiol, March 1, 2005; 288(3): H1324 - H1330.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
J. C. Walker, J. M. Guccione, Y. Jiang, P. Zhang, A. W. Wallace, E. W. Hsu, and M. B. Ratcliffe
Helical myofiber orientation after myocardial infarction and left ventricular surgical restoration in sheep
J. Thorac. Cardiovasc. Surg., February 1, 2005; 129(2): 382 - 390.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1976 by the American Physiological Society.