AJP - Heart Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 293: H2009-H2023, 2007. First published June 22, 2007; doi:10.1152/ajpheart.00522.2007
0363-6135/07 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
293/4/H2009    most recent
00522.2007v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (4)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cooper, S. A.
Right arrow Articles by Sowers, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cooper, S. A.
Right arrow Articles by Sowers, J. R.

INVITED REVIEW

Renin-angiotensin-aldosterone system and oxidative stress in cardiovascular insulin resistance

Shawna A. Cooper,1,3 Adam Whaley-Connell,1,3 Javad Habibi,1,3,4 Yongzhong Wei,1,3 Guido Lastra,1 Camila Manrique,1 Sameer Stas,1 and James R. Sowers1,2,3,4

Departments of 1Internal Medicine and 2Medical Pharmacology and Physiology and 3Diabetes and Cardiovascular Center of Excellence, University of Missouri School of Medicine, and 4Harry S. Truman Veterans Affairs Medical Center, Columbia, Missouri

Hypertension commonly occurs in conjunction with insulin resistance and other components of the cardiometabolic syndrome. Insulin resistance plays a significant role in the relationship between hypertension, Type 2 diabetes mellitus, chronic kidney disease, and cardiovascular disease. There is accumulating evidence that insulin resistance occurs in cardiovascular and renal tissue as well as in classical metabolic tissues (i.e., skeletal muscle, liver, and adipose tissue). Activation of the renin-angiotensin-aldosterone system and subsequent elevations in angiotensin II and aldosterone, as seen in cardiometabolic syndrome, contribute to altered insulin/IGF-1 signaling pathways and reactive oxygen species formation to induce endothelial dysfunction and cardiovascular disease. This review examines currently understood mechanisms underlying the development of resistance to the metabolic actions of insulin in cardiovascular as well as skeletal muscle tissue.


Address for reprint requests and other correspondence: J. R. Sowers, Director of the Missouri Univ. Diabetes and Cardiovascular Center, D109 HSC Diabetes Center, One Hospital Dr., Columbia, MO 65212 (e-mail: sowersj{at}health.missouri.edu)




This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
Y. Wei, K. Chen, A. T. Whaley-Connell, C. S. Stump, J. A. Ibdah, and J. R. Sowers
Skeletal muscle insulin resistance: role of inflammatory cytokines and reactive oxygen species
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2008; 294(3): R673 - R680.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
A. Whaley-Connell and J. R. Sowers
Obesity, Insulin Resistance, and Nocturnal Systolic Blood Pressure
Hypertension, March 1, 2008; 51(3): 620 - 621.
[Full Text] [PDF]

Home page
 Circ. Res.Home page
J.-a Kim, Y. Wei, and J. R. Sowers
Role of Mitochondrial Dysfunction in Insulin Resistance
Circ. Res., February 29, 2008; 102(4): 401 - 414.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2007 by the American Physiological Society.