HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (2) Citing Articles via Google Scholar Google Scholar Articles by Juric, D. Articles by Netticadan, T. Search for Related Content PubMed PubMed Citation Articles by Juric, D. Articles by Netticadan, T.

Prevention of concentric hypertrophy and diastolic impairment in aortic-banded rats treated with resveratrol

¹Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada; and ²Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, Connecticut

Submitted 8 August 2006 ; accepted in final form 27 September 2006

This study was designed to examine the effects of the antioxidant resveratrol on cardiac structure and function in pressure overload (PO)-induced cardiac hypertrophy. Male Sprague-Dawley rats were subjected to sham operation and the aortic banding procedure. A subgroup of sham control and aortic-banded rats were treated with resveratrol for 2 wk after surgery. Echocardiographic analysis of cardiac structure and function along with Western blot analysis of endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS), and redox factor-1 (ref-1) were performed in all groups after 4 wk of surgery. Banded rats showed significantly increased left ventricle-to-body weight ratio. Echocardiographic analysis showed that the interventricular septal wall thickness and left ventricular posterior wall thickness at systole and diastole were significantly increased in banded rats. Also, a significant increase in isovolumic relaxation time was observed in banded rats. Measured eNOS, iNOS, and ref-1 protein levels were significantly reduced in banded rats. Resveratrol treatment prevented the above changes in cardiac structure, function, and protein expression in banded rats. Aortic banding after 4 wk resulted in concentric remodeling and impaired contractile function due to PO on the heart. The 2-wk treatment with resveratrol was found to abolish PO-induced cardiac hypertrophy. Resveratrol may therefore be beneficial against PO-induced cardiac hypertrophy found in clinical settings of hypertension and aortic valve stenosis.

pressure overload; nitric oxide; redox factor-1

This article has been cited by other articles:

				A. Y. M. Chan, V. W. Dolinsky, C.-L. M. Soltys, B. Viollet, S. Baksh, P. E. Light, and J. R. B. Dyck Resveratrol Inhibits Cardiac Hypertrophy via AMP-activated Protein Kinase and Akt J. Biol. Chem., August 29, 2008; 283(35): 24194 - 24201. [Abstract] [Full Text] [PDF]

				B. Burstein, A. Maguy, R. Clement, H. Gosselin, F. Poulin, N. Ethier, J.-C. Tardif, T. E. Hebert, A. Calderone, and S. Nattel Effects of Resveratrol (trans-3,5,4'-Trihydroxystilbene) Treatment on Cardiac Remodeling following Myocardial Infarction J. Pharmacol. Exp. Ther., December 1, 2007; 323(3): 916 - 923. [Abstract] [Full Text] [PDF]