AJP - Heart Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 292: H884-H892, 2007. First published September 29, 2006; doi:10.1152/ajpheart.00796.2006
0363-6135/07 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
292/2/H884    most recent
00796.2006v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (3)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Feintuch, A.
Right arrow Articles by Ethier, C. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Feintuch, A.
Right arrow Articles by Ethier, C. R.

Hemodynamics in the mouse aortic arch as assessed by MRI, ultrasound, and numerical modeling

Akiva Feintuch,1 Permyos Ruengsakulrach,3 Amy Lin,4 Ji Zhang,4 Yu-Qing Zhou,1 Jonathon Bishop,1 Lorinda Davidson,1 David Courtman,5 F. Stuart Foster,6 David A. Steinman,4,7 R. Mark Henkelman,1,2 and C. Ross Ethier4,7

1Mouse Imaging Centre, Hospital for Sick Children, Toronto; 2Department of Medical Biophysics, University of Toronto; 3Department of Mathematics, Mahidol University, Bangkok, Thailand; 4Department of Mechanical and Industrial Engineering, University of Toronto; 5St. Michael's Hospital, Toronto; 6Sunnybrook Health Sciences Centre, Toronto; and 7Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada

Submitted 25 July 2006 ; accepted in final form 20 September 2006

Mice are widely used to study arterial disease in humans, and the pathogenesis of arterial diseases is known to be strongly influenced by hemodynamic factors. It is, therefore, of interest to characterize the hemodynamic environment in the mouse arterial tree. Previous measurements have suggested that many relevant hemodynamic variables are similar between the mouse and the human. Here we use a combination of Doppler ultrasound and MRI measurements, coupled with numerical modeling techniques, to characterize the hemodynamic environment in the mouse aortic arch at high spatial resolution. We find that the hemodynamically induced stresses on arterial endothelial cells are much larger in magnitude and more spatially uniform in the mouse than in the human, an effect that can be explained by fluid mechanical scaling principles. This surprising finding seems to be at variance with currently accepted models of the role of hemodynamics in atherogenesis and the known distribution of atheromatous lesions in mice.

atherogenesis; magnetic resonance imaging; finite element modeling; shear stress


Address for reprint requests and other correspondence: C. R. Ethier, Institute of Biomaterials and Biomedical Engineering, Univ. of Toronto, 164 College St., Toronto, ON M5S 3G9 Canada (e-mail: ethier{at}mie.utoronto.ca)




This article has been cited by other articles:


Home page
 CirculationHome page
G. P. Kwon, J. L. Schroeder, M. J. Amar, A. T. Remaley, and R. S. Balaban
Contribution of Macromolecular Structure to the Retention of Low-Density Lipoprotein at Arterial Branch Points
Circulation, June 3, 2008; 117(22): 2919 - 2927.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2007 by the American Physiological Society.