HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

Am J Physiol Heart Circ Physiol 292: H43-H55, 2007. First published September 22, 2006; doi:10.1152/ajpheart.00955.2006
0363-6135/07 $8.00

This Article Free upon publication Full Text Full Text (PDF) All Versions of this Article: 292/1/H43    most recent 00955.2006v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via ISI Web of Science (5) Citing Articles via Google Scholar Google Scholar Articles by Cherry, E. M. Articles by Fenton, F. H. Search for Related Content PubMed PubMed Citation Articles by Cherry, E. M. Articles by Fenton, F. H.

INVITED REVIEW

CALL FOR PAPERS
Computational Analysis in Ion Channelopathies

A tale of two dogs: analyzing two models of canine ventricular electrophysiology

¹Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca; ²Department of Physics and Astronomy, Hofstra University, Hempstead; and ³The Heart Institute, Beth Israel Medical Center, New York, New York

The extensive development of detailed mathematical models of cardiac myocyte electrophysiology in recent years has led to a proliferation of models, including many that model the same animal species and specific region of the heart and thus would be expected to have similar properties. In this paper we review and compare two recently developed mathematical models of the electrophysiology of canine ventricular myocytes. To clarify their similarities and differences, we also present studies using them in a range of preparations from single cells to two-dimensional tissue. The models are compared with each other and with new and previously published experimental results in terms of a number of their properties, including action potential morphologies; transmembrane currents during normal heart rates and during alternans; alternans onsets, magnitudes, and cessations; and reentry dynamics of spiral waves. Action potential applets and spiral wave movies for the two canine ventricular models are available online as supplemental material. We find a number of differences between the models, including their rate dependence, alternans dynamics, and reentry stability, and a number of differences compared with experiments. Differences between models of the same species and region of the heart are not unique to these canine models. Similar differences can be found in the behavior of two models of human ventricular myocytes and of human atrial myocytes. We provide several possible explanations for the differences observed in models of the same species and region of the heart and discuss the implications for the applicability of models in addressing questions of mechanism in cardiac electrophysiology.

ionic models; ventricular arrhythmias; electrical alternans