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Am J Physiol Heart Circ Physiol 291: H2555-H2556, 2006; doi:10.1152/classicessays.00044.2006
0363-6135/06 $8.00

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EDITORIAL FOCUS

ESSAYS ON APS CLASSIC PAPERS

Relating cardiac performance with oxygen consumption: historical observations continue to spawn scientific discovery

Departments of Medicine and Physiology, Medical College of Wisconsin, and Veterans Affairs Medical Center, Milwaukee, Wisconsin

ABSTRACT

This essay examines the historical significance of two APS classic papers that are freely available online:

NEELY JR, LIEBERMEISTER H, BATTERSBY EJ, AND MORGAN HE.: Effect of pressure development on oxygen consumption by isolated rat heart. Am J Physiol 212: 804–814, 1967 (http://ajplegacy.physiology.org/cgi/reprint/212/4/804).

SARNOFF SJ, BRAUNWALD E, WELCH GH JR, CASE RB, STAINSBY WN, AND MACRUZ R.: Hemodynamic determinants of oxygen consumption of the heart with special reference to the tension-time index. Am J Physiol 192: 148–156, 1957 (http://ajplegacy.physiology.org/cgi/reprint/192/1/148).