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This Article Full Text Full Text (PDF) All Versions of this Article: 291/2/H564    most recent 00915.2005v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via ISI Web of Science (3) Citing Articles via Google Scholar Google Scholar Articles by Kiviniemi, T. O. Articles by Koskenvuo, J. W. Search for Related Content PubMed PubMed Citation Articles by Kiviniemi, T. O. Articles by Koskenvuo, J. W.

Determinants of coronary flow velocity reserve in healthy young men

¹Department of Clinical Physiology, Nuclear Medicine and PET, Turku University Hospital; and the ²Department of Pharmacology and Clinical Pharmacology, University of Turku, and the ³MCA Research Laboratory, Department of Physiology, University of Turku, Turku, Finland; and the ⁴Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland

Submitted 24 August 2005 ; accepted in final form 21 February 2006

The objective of this study was to identify risk markers for attenuated coronary flow velocity reserve (CFVR) that exist in healthy young men without evident atherosclerotic risk factors. Coronary blood flow velocity was measured with transthoracic Doppler echocardiography at baseline and during adenosine infusion in 37 healthy nonsmoking men [mean age, 27 yr (SD 4.0)]. Body composition and distribution of fat tissue were assessed with anthropometric measures and regulation of fat metabolism by determination of adiponectin and leptin levels. Physical performance capacity was tested with ergospirometry. The mean body mass index was 23 kg/m² (SD 1.9), waist-to-hip ratio was 0.84 (SD 0.04), and CFVR was 3.5 (SD 0.61). Obesity indexes at study outset, leptin, adiponectin, maximal load (Max load in W/kg) and maximal oxygen consumption (O₂ peak in ml·kg^–1·min^–1) in ergospirometry, rate-pressure product, and heart rate at rest were significantly associated with CFVR. In multivariate analysis, Max load (in W/kg) and waist-to-hip ratio were the only independent predictors of CFVR. We found no relationship between CFVR and serum lipids or body mass index. We conclude that abdominal fat accumulation and low aerobic fitness are independently associated with CFVR in men.

transthoracic Doppler echocardiography; physical capacity in ergospirometry; visceral adipose tissue