| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1Laboratoire de Physiopathologie de la Paroi Artérielle, Faculté de Médecine, 37032 Tours Cedex; 2Centre de Recherche, Pfizer, 37401 Amboise; 3Institut Fédirati de Recherche 135, Imagerie et Exploration Fonctionnelle, 37032 Tours Cedex, France
Submitted 18 August 2003 ; accepted in final form 10 March 2004
The purpose of this study was to evaluate the reversibility of right ventricular (RV) remodelling after pulmonary artery hypertension (PAHT) secondary to 3 wk of hypobaric hypoxia. A group of 10 adult male Wistar rats were studied and were the following: control normoxic (C), after 3 wk of chronic hypoxia (CH), and after 3 wk of exposure to hypoxia followed by 3 wk of normoxia recovery (N-RE). Mean pulmonary artery pressure was 11 ± 2 mmHg in the C group, 35 ± 2 mmHg in the CH group, and 14 ± 3 mmHg in the N-RE group. RV function was assessed by echocardiography. In the CH group, the pulmonary flow measured in Doppler mode depicted a midsystolic notch and a decrease of the pulmonary acceleration time compared with control [17 ± 1 vs. 34 ± 1 ms (n = 10), respectively; P < 0.05]. RV thickening measured in M-mode was apparent in the CH group compared with the control group [2.84 ± 0.40 vs. 1.73 ± 0.26 mm (n = 10), P < 0.05]. In the N-RE group, the RV wall was significantly thinner compared with the CH group [1.56 ± 0.08 vs. 1.73 ± 0.26 mm (n = 10), P < 0.05]. The calculated RV diameter shortness fraction was not different between the CH group and C group (34 ± 4.2% vs. 36 ± 2.8%) but decreased in the N-RE group [20 ± 2.4% (n = 10), P < 0.01]. The E-to-A wave ratio on the tricuspid Doppler inflow was significantly lower in the CH group and N-RE group compared with the C group [0.70 ± 0.8 and 0.72 ± 0.1 vs. 0.88 ± 0.2 (n = 10), respectively; P < 0.05]. In the isolated perfused heart using the Langendorff method, RV compliance was increased in the CH group and decreased in the N-RE group. In the N-RE group, fibrous bands with metaplasia were observed on histological sections of the RV free wall. We conclude that PAHT induces nonreversible RV dysfunction with dysplasia.
pulmonary hypertension; echocardiography; remodelling
This article has been cited by other articles:
|
|
 |
|
  F. Akhavein, E. J. St.-Michel, E. Seifert, and C. V. Rohlicek Decreased left ventricular function, myocarditis, and coronary arteriolar medial thickening following monocrotaline administration in adult rats J Appl Physiol, July 1, 2007; 103(1): 287 - 295. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Y. Rochefort, B. Delorme, A. Lopez, O. Herault, P. Bonnet, P. Charbord, V. Eder, and J. Domenech Multipotential Mesenchymal Stem Cells Are Mobilized into Peripheral Blood by Hypoxia Stem Cells, October 1, 2006; 24(10): 2202 - 2208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Boissiere, M. Gautier, M.-C. Machet, G. Hanton, P. Bonnet, and V. Eder Doppler tissue imaging in assessment of pulmonary hypertension-induced right ventricle dysfunction Am J Physiol Heart Circ Physiol, December 1, 2005; 289(6): H2450 - H2455. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Ladha, S. Bonnet, F. Eaton, K. Hashimoto, G. Korbutt, and B. Thebaud Sildenafil Improves Alveolar Growth and Pulmonary Hypertension in Hyperoxia-induced Lung Injury Am. J. Respir. Crit. Care Med., September 15, 2005; 172(6): 750 - 756. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
