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EB2003 SYMPOSIUM
Mitochondrial Nitric Oxide

A mitochondrial role for catabolism of nitric oxide in cardiomyocytes not involving oxymyoglobin

¹Department of Chemistry, Carnegie Mellon University, Pittsburgh 15213; ²Renal Electrolyte Division, University of Pittsburgh School of Medicine, Pittsburgh 15261; and ³Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15260

Submitted 1 August 2003 ; accepted in final form 12 August 2003

The maximal concentration of nitric oxide (NO) developing in cultured cells following stimulation of endogenous NO synthases was shown to be submicromolar by NO-selective microelectrode measurements. In electron paramagnetic resonance experiments with isolated and finely divided pericardium, NO was found to react with oxymyoglobin to form metmyoglobin provided that NO was supplied at concentrations in excess of a few micromolar. However, at NO concentrations achievable by endogenous sources, this reaction did not take place to any measurable extent. Oxidative conversion of NO to nitrite ion by cytochrome c oxidase appears to be the most plausible route for cellular catabolism of NO.

complex IV; electron paramagnetic resonance; mitochondria; myoglobin; nitrite

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