AJP - Heart Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 281: H2473-H2479, 2001;
0363-6135/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (21)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Swoap, S. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Swoap, S. J.
Vol. 281, Issue 6, H2473-H2479, December 2001

Altered leptin signaling is sufficient, but not required, for hypotension associated with caloric restriction

Steven J. Swoap

Department of Biology, Williams College, Williamstown, Massachusetts 01267

Caloric restriction of mammals leads to decreases in blood pressure and heart rate. Although relevant clinically, the mechanisms involved, in terms of hormones and signaling pathways invoked, are currently not known. Circumstantial evidence suggests that leptin signaling may be involved with the bradycardia and hypotension associated with caloric restriction. This hypothesis was specifically tested using leptin-deficient mice (ob/ob) or leptin-receptor rats (Koletsky). Ob/ob mice were hypertensive during the light cycle relative to littermate controls (108 ± 2 vs. 100 ± 2 mmHg, respectively). Both ob/ob mice and wild-type mice exhibited hypotension and bradycardia on initiation of a 50% caloric restriction regime, suggesting that the loss of leptin during caloric restriction is not required to explain the cardiovascular effects. Blood pressure in Koletsky rats did not drop in response to caloric restriction during the light cycle, whereas blood pressure in littermate control rats significantly dropped. These data suggest that at least two pathways are involved with cardiovascular effects of caloric restriction: one dependent on leptin signaling and the other independent of the leptin axis.

hypertension; blood pressure; food restriction; beta -myosin heavy chain


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. J. Swoap, C. Li, J. Wess, A. D. Parsons, T. D. Williams, and J. M. Overton
Vagal tone dominates autonomic control of mouse heart rate at thermoneutrality
Am J Physiol Heart Circ Physiol, April 1, 2008; 294(4): H1581 - H1588.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. J. Swoap, M. Rathvon, and M. Gutilla
AMP does not induce torpor
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R468 - R473.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. L. Sowden, D. J. Drucker, D. Weinshenker, and S. J. Swoap
Oxyntomodulin increases intrinsic heart rate in mice independent of the glucagon-like peptide-1 receptor
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2007; 292(2): R962 - R970.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. F. Gluck, N. Stephens, and S. J. Swoap
Peripheral ghrelin deepens torpor bouts in mice through the arcuate nucleus neuropeptide Y signaling pathway
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2006; 291(5): R1303 - R1309.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
T. Jiang, S. E. Liebman, M. S. Lucia, C. L. Phillips, and M. Levi
Calorie Restriction Modulates Renal Expression of Sterol Regulatory Element Binding Proteins, Lipid Accumulation, and Age-Related Renal Disease
J. Am. Soc. Nephrol., August 1, 2005; 16(8): 2385 - 2394.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
L. M. Hunt, E. W. Hogeland, M. K. Henry, and S. J. Swoap
Hypotension and bradycardia during caloric restriction in mice are independent of salt balance and do not require ANP receptor
Am J Physiol Heart Circ Physiol, October 1, 2004; 287(4): H1446 - H1451.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. J. Swoap, J. M. Overton, and G. Garber
Effect of ambient temperature on cardiovascular parameters in rats and mice: a comparative approach
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2004; 287(2): R391 - R396.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. J. Swoap, D. Weinshenker, R. D. Palmiter, and G. Garber
Dbh(-/-) mice are hypotensive, have altered circadian rhythms, and have abnormal responses to dieting and stress
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2004; 286(1): R108 - R113.
[Abstract] [Full Text]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
K. Stephenson, J. Tunstead, A. Tsai, R. Gordon, S. Henderson, and H. M. Dansky
Neointimal Formation After Endovascular Arterial Injury Is Markedly Attenuated in db/db Mice
Arterioscler. Thromb. Vasc. Biol., November 1, 2003; 23(11): 2027 - 2033.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. D. Williams, J. B. Chambers, R. P. Henderson, M. E. Rashotte, and J. M. Overton
Cardiovascular responses to caloric restriction and thermoneutrality in C57BL/6J mice
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2002; 282(5): R1459 - R1467.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online