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1 Department of Medicine, Division of Cardiology, and 2 Department of Health Evaluation Sciences, Milton S. Hershey Medical Center, The Pennsylvania State University College of Medicine, Hershey 17033; and 3 Lebanon Veterans Affairs Medical Center, Lebanon, Pennsylvania 17042
We examined the
effects of dynamic one-legged knee extension exercise on mean blood
velocity (MBV) and muscle interstitial metabolite concentrations in
healthy young subjects (n = 7). Femoral MBV (Doppler),
mean arterial pressure (MAP) and muscle interstitial metabolite
(adenosine, lactate, phosphate, K+, pH, and H+;
by microdialysis) concentrations were measured during 5 min of exercise
at 30 and 60% of maximal work capacity (Wmax). MAP increased (P < 0.05) to a similar extent during the
two exercise bouts, whereas the increase in MBV was greater
(P < 0.05) during exercise at 60% (77.00 ± 6.77 cm/s) compared with 30% Wmax (43.71 ± 3.71 cm/s).
The increase in interstitial adenosine from rest to exercise was
greater (P < 0.05) during the 60% (0.80 ± 0.10 µM) compared with the 30% Wmax bout (0.57 ± 0.10 µM). During exercise at 60% Wmax, interstitial
K+ rose at a greater rate than during exercise at 30%
Wmax (P < 0.05). However, pH increased
(H+ decreased) at similar rates for the two exercise
intensities. During exercise, interstitial lactate and phosphate
increased (P < 0.05) with no difference observed
between the two intensities. After 5 min of recovery, MBV decreased to
baseline levels after exercise at 30% Wmax (4.12 ± 1.10 cm/s), whereas MBV remained above baseline levels after exercise
at 60% Wmax (
19.46 ± 2.61 cm/s; P < 0.05). MAP and interstitial adenosine, K+, pH, and
H+ returned toward baseline levels. However, interstitial
lactate and phosphate continued to increase during the recovery period. Thus an increase in exercise intensity resulted in concomitant changes
in MBV and muscle interstitial adenosine and K+, whereas
similar changes were not observed for MAP or muscle interstitial pH,
lactate, or phosphate. These data suggest that K+ and/or
adenosine may play an active role in the regulation of skeletal muscle
blood flow during exercise.
vasodilation; blood flow; microdialysis
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