| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Division of Cardiology, Department of Medicine, University of California, San Francisco 94143; and 2 Cardiology Division and Research Service, Veterans Affairs Medical Center, San Francisco, California 94121
Transverse aortic constriction (TAC) is an effective technique for inducing left ventricular (LV) hypertrophy in mice. With the use of transthoracic echocardiography and Doppler measurements, we studied the effects of an acute increase in pressure overload on LV contractile performance and peak systolic wall stress index (WSI) at early time points after TAC and the time course of the development of LV hypertrophy in mice. The LV mass index was similar between TAC and sham-operated mice at postoperative day 1 but progressively increased in TAC mice by day 10. There was no further increase in the LV mass index between postoperative days 10 and 20. On day 1, whereas peak systolic WSI increased significantly, the LV ejection fraction (LVEF) and percent fractional shortening (%FS) decreased in TAC mice compared with sham-operated mice. By day 10, peak systolic WSI, LVEF, and %FS had recovered to baseline levels and were not significantly different between postoperative days 10 and 20. Thus LV systolic performance in mice declines immediately after TAC, associated with increased peak systolic WSI, but recovers to baseline levels with the development of compensatory LV hypertrophy over 10-20 days.
echocardiography; left ventricular function
This article has been cited by other articles:
|
|
 |
|
  G. Cheng, M. R. Zile, M. Takahashi, C. F. Baicu, D. D. Bonnema, F. Cabral, D. R. Menick, and G. Cooper 4th A direct test of the hypothesis that increased microtubule network density contributes to contractile dysfunction of the hypertrophied heart Am J Physiol Heart Circ Physiol, May 1, 2008; 294(5): H2231 - H2241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Chess, B. Lei, B. D. Hoit, A. M. Azimzadeh, and W. C. Stanley Deleterious effects of sugar and protective effects of starch on cardiac remodeling, contractile dysfunction, and mortality in response to pressure overload Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1853 - H1860. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-Y. Yang, C.-F. Cheng, B. Djoko, W.-S. Lian, C.-F. Tu, M.-T. Tsai, Y.-H. Chen, C.-C. Chen, C.-J. Cheng, and R.-B. Yang Transgenic overexpression of the secreted, extracellular EGF-CUB domain-containing protein SCUBE3 induces cardiac hypertrophy in mice Cardiovasc Res, July 1, 2007; 75(1): 139 - 147. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Lee, Q. Fang, P. A. Davol, Y. Gu, R. E. Sievers, R. C. Grabert, J. M. Gall, E. Tsang, M. S. Yee, H. Fok, et al. Antibody Targeting of Stem Cells to Infarcted Myocardium Stem Cells, March 1, 2007; 25(3): 712 - 717. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. M. R. Carvalho, R. A. Bassani, K. G. Franchini, and J. W. M. Bassani Enhanced calcium mobilization in rat ventricular myocytes during the onset of pressure overload-induced hypertrophy Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1803 - H1813. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kamba, B. Y. Y. Tam, H. Hashizume, A. Haskell, B. Sennino, M. R. Mancuso, S. M. Norberg, S. M. O'Brien, R. B. Davis, L. C. Gowen, et al. VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature Am J Physiol Heart Circ Physiol, February 1, 2006; 290(2): H560 - H576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Springer, R. E. Sievers, M. N. Viswanathan, M. S. Yee, E. Foster, W. Grossman, and Y. Yeghiazarians Closed-chest cell injections into mouse myocardium guided by high-resolution echocardiography Am J Physiol Heart Circ Physiol, September 1, 2005; 289(3): H1307 - H1314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Berenji, M. H. Drazner, B. A. Rothermel, and J. A. Hill Does load-induced ventricular hypertrophy progress to systolic heart failure? Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H8 - H16. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-M. Gao, H. Kiriazis, X.-L. Moore, X.-H. Feng, K. Sheppard, A. Dart, and X.-J. Du Regression of pressure overload-induced left ventricular hypertrophy in mice Am J Physiol Heart Circ Physiol, June 1, 2005; 288(6): H2702 - H2707. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Holmes Candidate mechanical stimuli for hypertrophy during volume overload J Appl Physiol, October 1, 2004; 97(4): 1453 - 1460. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Mirotsou, C. M.H. Watanabe, P. G. Schultz, R. E. Pratt, and V. J. Dzau Elucidating the molecular mechanism of cardiac remodeling using a comparative genomic approach Physiol Genomics, October 17, 2003; 15(2): 115 - 126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. O. Weinberg, M. Mirotsou, J. Gannon, V. J. Dzau, R. T. Lee, and R. E. Pratt Sex dependence and temporal dependence of the left ventricular genomic response to pressure overload Physiol Genomics, January 15, 2003; 12(2): 113 - 127. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
