AJP - Heart Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 281: H298-H307, 2001;
0363-6135/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (15)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jernigan, N. L.
Right arrow Articles by Walker, B. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jernigan, N. L.
Right arrow Articles by Walker, B. R.
Vol. 281, Issue 1, H298-H307, July 2001

Correlation of HO-1 expression with onset and reversal of hypoxia-induced vasoconstrictor hyporeactivity

Nikki L. Jernigan, Theresa L. O'Donaughy, and Benjimen R. Walker

Vascular Physiology Group, Department of Cell Biology and Physiology, University of New Mexico Health Science Center, Albuquerque, New Mexico 87131-5218

Rats exposed to chronic hypoxia (CH; 4 wk at 0.5 atm) exhibit attenuated renal vasoconstrictor reactivity to phenylephrine (PE). Preliminary studies from our laboratory suggest that this response is mediated by hypoxic induction of heme oxygenase (HO) and subsequent release of the endogenous vasodilator carbon monoxide. Because vascular HO mRNA is increased within hours of hypoxic exposure, we hypothesized that the onset of reduced reactivity may occur fairly rapidly and correlate with HO expression. Therefore, we examined the onset of attenuated vasoconstriction on CH exposure as well as the duration of hyporeactivity on return to a normoxic environment. Renal vascular resistance (RVR) responses to graded intravenous infusion of PE were measured in conscious rats under control conditions and after 24 h, 48 h, and 4 wk of CH exposure. Vasoreactivity responses were also determined in 4-wk CH rats 1, 5, 24, and 96 h after return to normoxia. We found that RVR responses to PE were significantly blunted after 48 h and 4 wk but not after 24 h of hypoxic exposure. Inhibition of HO with zinc protoporphyrin IX increased RVR and decreased renal blood flow in 48-h CH rats but not controls. Although reactivity to PE was gradually restored after 4 wk of CH, responsiveness was still slightly blunted at 96 h after return to normoxia. Western blot analysis demonstrated a correlation between HO-1 protein levels and attenuated vasoconstrictor response in CH and posthypoxic rats. These data suggest that the onset and offset of physiologically relevant vascular HO expression occur within 2-3 days.

heme oxygenase; conscious rats; renal blood flow; chronic hypoxia; zinc protoporphyrin IX


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
S. A. Phillips, E. B. Olson, J. H. Lombard, and B. J. Morgan
Chronic intermittent hypoxia alters NE reactivity and mechanics of skeletal muscle resistance arteries
J Appl Physiol, April 1, 2006; 100(4): 1117 - 1123.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
P. Achouh, S. Simonet, C. Badier-Commander, C. Chardigny, C. Vayssettes-Courchay, R. Zegdi, Z. Khabbaz, J.-N. Fabiani, and T. J. Verbeuren
The induction of heme oxygenase 1 decreases contractility in human internal thoracic artery and radial artery grafts
J. Thorac. Cardiovasc. Surg., December 1, 2005; 130(6): 1573 - 1580.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
H. Resch, C. Zawinka, G. Weigert, L. Schmetterer, and G. Garhofer
Inhaled Carbon Monoxide Increases Retinal and Choroidal Blood Flow in Healthy Humans
Invest. Ophthalmol. Vis. Sci., November 1, 2005; 46(11): 4275 - 4280.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
V. Govindaraju, H. Teoh, Q. Hamid, P. Cernacek, and M. E. Ward
Interaction between endothelial heme oxygenase-2 and endothelin-1 in altered aortic reactivity after hypoxia in rats
Am J Physiol Heart Circ Physiol, February 1, 2005; 288(2): H962 - H970.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. Villamor, C. G. A. Kessels, K. Ruijtenbeek, R. J. van Suylen, J. Belik, J. G. R. De Mey, and C. E. Blanco
Chronic in ovo hypoxia decreases pulmonary arterial contractile reactivity and induces biventricular cardiac enlargement in the chicken embryo
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2004; 287(3): R642 - R651.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
F. Rodriguez, R. Kemp, M. Balazy, and A. Nasjletti
Effects of Exogenous Heme on Renal Function: Role of Heme Oxygenase and Cyclooxygenase
Hypertension, October 1, 2003; 42(4): 680 - 684.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. Earley, A. Pastuszyn, and B. R. Walker
Cytochrome P-450 epoxygenase products contribute to attenuated vasoconstriction after chronic hypoxia
Am J Physiol Heart Circ Physiol, June 5, 2003; 285(1): H127 - H136.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. S. Naik and B. R. Walker
Heme oxygenase-mediated vasodilation involves vascular smooth muscle cell hyperpolarization
Am J Physiol Heart Circ Physiol, June 5, 2003; 285(1): H220 - H228.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
F. Rodriguez, F. Zhang, S. Dinocca, and A. Nasjletti
Nitric oxide synthesis influences the renal vascular response to heme oxygenase inhibition
Am J Physiol Renal Physiol, June 1, 2003; 284(6): F1255 - F1262.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. Earley and B. R. Walker
Increased nitric oxide production following chronic hypoxia contributes to attenuated systemic vasoconstriction
Am J Physiol Heart Circ Physiol, May 1, 2003; 284(5): H1655 - H1661.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. S. Naik, T. L. O'Donaughy, and B. R. Walker
Endogenous carbon monoxide is an endothelial-derived vasodilator factor in the mesenteric circulation
Am J Physiol Heart Circ Physiol, March 1, 2003; 284(3): H838 - H845.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. Earley and B. R. Walker
Endothelium-dependent blunting of myogenic responsiveness after chronic hypoxia
Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2202 - H2209.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. Mukundan, T. C. Resta, and N. L. Kanagy
17beta -Estradiol decreases hypoxic induction of erythropoietin gene expression
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2002; 283(2): R496 - R504.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. Earley, J. S. Naik, and B. R. Walker
48-h Hypoxic exposure results in endothelium-dependent systemic vascular smooth muscle cell hyperpolarization
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2002; 283(1): R79 - R85.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
R. J. Gonzales and B. R. Walker
Role of CO in attenuated vasoconstrictor reactivity of mesenteric resistance arteries after chronic hypoxia
Am J Physiol Heart Circ Physiol, January 1, 2002; 282(1): H30 - H37.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online