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1 Department of Medical Physics, Cardiovascular Research Institute Amsterdam, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands; 2 Cardiology Division, Johns Hopkins University, School of Medicine, Baltimore, MD 21287; 3 Man-Machine Systems and Control Group, Faculty of Design, Engineering and Production, Delft University of Technology, 2628 CD Delft, The Netherlands; and 4 Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri 63130
Varying coronary
volume will vary vascular resistance and thereby have an effect
on coronary hemodynamics. Six ventricular septa were isolated from
anesthetized dogs, dispersed in a biaxial stretch apparatus at
diastolic stress, and perfused artificially with an oxygenated
perfluorochemical emulsion at maximal vasodilation. Flow and thickness
were measured continuously by an electromagnetic flow probe and
sonomicrometer. Pressure was varied sinusoidally around
30, 50, and 70 mmHg with an amplitude of 7.5 mmHg; frequencies ranged
between 0.015 and 7 Hz. Bode plots of admittance (flow/pressure) and
capacitance (scaled thickness/pressure) were constructed. A
two-compartment model was used in which the resistances vary with
volume. Realistic values of microvascular compliance (~0.3 ml · mmHg
1 · 100 g1) were found. Values 10 times higher were then
found when resistances were forced to be constant. We concluded that
volume dependence of resistances have to be taken into account when
dynamic or static pressure-flow relations are studied and conceal the
effect of a large intramyocardial compliance on arterial hemodynamics.
intramyocardial compliance; model; transfer function; admittance; pressure-dependent resistance
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