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Am J Physiol Heart Circ Physiol 274: H2074-H2084, 1998;
0363-6135/98 $5.00
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Vol. 274, Issue 6, H2074-H2084, June 1998

Intrinsic neural regulation of the heart in the chronic, conscious dog

Donald V. Priola1, Xiaoling Cao1, Constantine Anagnostelis1, and Eberhard Bassenge2

1 Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131; and 2 Institüt für Angewandte Physiologie, Universität Freiburg, 79104 Freiburg, Germany

The present experiments were performed to examine the capability of the intrinsic cardiac nerves (ICN) to modify cardiac performance in the resting chronic, conscious dog. Control and cardiac-denervated dogs were instrumented for recording of left atrial (LA) and ventricular (LV) contractility, heart rate, and atrioventricular (AV) conduction time. Acetylcholine (ACh) and nicotine (Nic) were administered via an indwelling coronary artery catheter. Limited distribution from the injection site only allowed access to the LA, LV, and AV node. Both beta -blockade with timolol and cardiac denervation were used to separate direct effects of ICN stimulation from indirect (e.g., reflex) effects. ACh produced the expected negative inotropic and dromotropic changes. ICN stimulation with Nic caused large decreases in LA contractility along with depression of AV conduction but only trivial effects on the LV. We concluded that the ICN has limited effects on cardiac performance in the resting animal under minimal sympathetic drive. It is likely, however, that the ICN is capable of significantly depressing cardiac function under conditions of elevated sympathetic tone as would be encountered in exercise.

intrinsic cardiac nerves; parasympathetic nervous system; nicotine; cardiac innervation; cardiac ganglia


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