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Institut National de la Santé et de la Recherche Médicale, U451-Loa-Ensta-Ecole Polytechnique, 91125 Palaiseau Cédex; Service de Physiologie Cardio-Respiratoire, Université de Paris XI, Hôpital de Bicêtre, 94275 Le Kremlin Bicêtre; and Service de Cardiologie, Hôpital Antoine-Béclère, 92141 Clamart, France
On the basis of
the windkessel model, the stroke volume-to-aortic pulse
pressure ratio (SV/PP) has been proposed as an estimate of total
arterial compliance, but recent studies have questioned this
approximation. Aortic pressure was obtained at rest in 31 adults
undergoing cardiac catheterization (47 ± 14 yr): controls (n = 7), patients with dilated
cardiomyopathy (n = 10), and patients with other cardiac diseases (n = 14).
We calculated PP, mean aortic pressure (MAoP), heart period
(T), SV (thermodilution cardiac output/heart rate), total peripheral resistance
(R), total arterial compliance
estimated by area method
(Carea), and
the time constant of aortic pressure decay in diastole
(RCarea). In
the overall population (n = 31), there
was no significant difference between SV/PP and
Carea. SV/PP was
linearly related to
Carea (SV/PP = 0.99Carea + 0.05;
r = 0.98;
P < 0.001); the slope and intercept did not differ from unity and zero, respectively. Similar results were
obtained in the three subgroups. These results implied that PP/MAoP and
T/RCarea
were proportionally related
(T/RCarea = 1.18PP/MAoP 
0.07; r = 0.96;
P < 0.001). We conclude that for
humans at rest 1) SV/PP gave a
reliable estimate of
Carea, and
2)
T normalized by the time constant of
aortic pressure decay in diastole was proportionally related to
PP/MAoP. This last relationship could be considered an aspect of the
coupling between the left ventricle and its load.
heart period; ventricular-arterial coupling; wave reflection
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