| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Physiology and Clinical Pharmacology, Faculty of Pharmacy, Centre National de la Recherche Scientifique, Unité Propre de Recherche de l'Enseignement Supérieur Associée 5014, Faculty of Pharmacy, 69373 Lyon Cedex 08, France
A windkessel model was applied on a
beat-to-beat basis to evaluate the arterial mechanical characteristics
in seven conscious rats. Ascending aortic arterial pressure (AP) and
blood flow were recorded during steady-state in basal conditions,
during infusions of isoprenaline, sodium nitroprusside, and
phenylephrine, and after intravenous atenolol injection. For each
cardiac cycle the exponential decay time constant (
)
was estimated from the aortic AP curve, peripheral resistances
(R) were taken as the ratio of mean
AP to cardiac output, and systemic arterial compliance
(C) was calculated as
/R. In all conditions, mean
correlation coefficients of the exponential regression and ~70% of
values in each rat were >0.99, demonstrating the model validity. In
all conditions and C exhibited a
large spontaneous variability over time, and beat-to-beat correlations
were high between and C (0.83 ± 0.03). C was increased by sodium
nitroprusside, decreased by isoprenaline, but not significantly decreased by phenylephrine [5.1 ± 0.2, 3.2 ± 0.3, and 3.9 ± 0.2 µl/mmHg, respectively, vs. 4.2 ± 0.3 µl/mmHg
(baseline)]. In conclusion, the windkessel model
enables and C to be reliably
estimated in conscious rats during spontaneous and drug-induced
hemodynamic variations.
exponential decay time; aortic blood pressure; cardiac output
This article has been cited by other articles:
|
|
 |
|
  M. W. Mohiuddin, G. A. Laine, and C. M. Quick Increase in pulse wavelength causes the systemic arterial tree to degenerate into a classical windkessel Am J Physiol Heart Circ Physiol, August 1, 2007; 293(2): H1164 - H1171. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Stoyanova, M. Trudel, H. Felfly, D. Garcia, and G. Cloutier Characterization of circulatory disorders in {beta}-thalassemic mice by noninvasive ultrasound biomicroscopy Physiol Genomics, March 14, 2007; 29(1): 84 - 90. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Poelaert The Failing Heart Under Stress: Echocardiography is an Essential Monitoring Tool in the Intensive Care Unit Seminars in Cardiothoracic and Vascular Anesthesia, March 1, 2006; 10(1): 111 - 115. [Abstract] [PDF]
|
|
|
|
|
|
J. R. Heerman, P. Segers, C. D. Roosens, F. Gasthuys, P. R. Verdonck, and J. I. Poelaert Echocardiographic assessment of aortic elastic properties with automated border detection in an ICU: in vivo application of the arctangent Langewouters model Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2504 - H2511. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. D. O'Leary, J. K. Shoemaker, M. R. Edwards, and R. L. Hughson Spontaneous beat-by-beat fluctuations of total peripheral and cerebrovascular resistance in response to tilt Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2004; 287(3): R670 - R679. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Cerutti, M. P. Gustin, P. Molino, and C. Z. Paultre Beat-to-beat stroke volume estimation from aortic pressure waveform in conscious rats: comparison of models Am J Physiol Heart Circ Physiol, September 1, 2001; 281(3): H1148 - H1155. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
