| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Heart and Circulatory Physiology, Vol 273, Issue 3 1255-H1265, Copyright © 1997 by American Physiological Society
ARTICLES |
W. D. Ito, M. Arras, D. Scholz, B. Winkler, P. Htun and W. Schaper
Max-Planck-Institute, Department of Experimental Cardiology, Bad Nauheim, Germany.
It remains unclear whether capillary sprouting (angiogenesis) and in situ growth of muscular collateral arteries share the same or different molecular mechanisms. To study the role of ischemia in these two forms of vascular proliferation, we measured tissue flows and maximum collateral conductances in hindlimbs of 22 rabbits previously subjected to either acute, 7-day, 21-day, or no femoral artery occlusion. After 1 wk of femoral artery occlusion, corkscrew collaterals were observed radiographically in the thigh. These collaterals showed histochemical evidence for active proliferation of endothelial and smooth muscle cells. Maximum collateral conductance increased sixfold in the 1st wk. Perfusion deficits, however, were only observed in the distal adductor muscles (region of collateral reentry). In the lower leg, which suffered from a profound perfusion deficit, conductance increased in the absence of any visible collateral arteries but with evidence for capillary proliferation. This study therefore demonstrates that upon femoral artery occlusion angiogenesis occurs in regions of profound ischemia, whereas no direct correlation can be drawn between ischemia and collateral artery development.
This article has been cited by other articles:
|
|
 |
|
  G. Cheng, H. Zhang, X. Yang, E. Tzima, K. L. Ewalt, P. Schimmel, and J. E. Faber Effect of mini-tyrosyl-tRNA synthetase on ischemic angiogenesis, leukocyte recruitment, and vascular permeability Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2008; 295(4): R1138 - R1146. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Taylor, Z. Li, H. T. Yang, M. H. Laughlin, and R. L. Terjung {alpha}-Adrenergic inhibition increases collateral circuit conductance in rats following acute occlusion of the femoral artery J. Physiol., March 15, 2008; 586(6): 1649 - 1667. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Varma, B. K. Lal, R. Zheng, J. W. Breslin, S. Saito, P. J. Pappas, R. W. Hobson II, and W. N. Duran Hyperglycemia alters PI3k and Akt signaling and leads to endothelial cell proliferative dysfunction Am J Physiol Heart Circ Physiol, October 1, 2005; 289(4): H1744 - H1751. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Lloyd, B. M. Prior, H. Li, H. T. Yang, and R. L. Terjung VEGF receptor antagonism blocks arteriogenesis, but only partially inhibits angiogenesis, in skeletal muscle of exercise-trained rats Am J Physiol Heart Circ Physiol, February 1, 2005; 288(2): H759 - H768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. M. Prior, P. G. Lloyd, J. Ren, H. Li, H. T. Yang, M. H. Laughlin, and R. L. Terjung Time course of changes in collateral blood flow and isolated vessel size and gene expression after femoral artery occlusion in rats Am J Physiol Heart Circ Physiol, December 1, 2004; 287(6): H2434 - H2447. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Khmelewski, A. Becker, T. Meinertz, and W. D. Ito Tissue Resident Cells Play a Dominant Role in Arteriogenesis and Concomitant Macrophage Accumulation Circ. Res., September 17, 2004; 95(6): e56 - e64. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kinnaird, E. Stabile, M. S. Burnett, and S. E. Epstein Bone Marrow-Derived Cells for Enhancing Collateral Development: Mechanisms, Animal Data, and Initial Clinical Experiences Circ. Res., August 20, 2004; 95(4): 354 - 363. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Duvall, W. Robert Taylor, D. Weiss, and R. E. Guldberg Quantitative microcomputed tomography analysis of collateral vessel development after ischemic injury Am J Physiol Heart Circ Physiol, July 1, 2004; 287(1): H302 - H310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Srivastava, R. L. Terjung, and H. T. Yang Basic fibroblast growth factor increases collateral blood flow in spontaneously hypertensive rats Am J Physiol Heart Circ Physiol, August 7, 2003; 285(3): H1190 - H1197. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Buckwalter, V. C. Curtis, Z. Valic, S. B. Ruble, and P. S. Clifford Endogenous vascular remodeling in ischemic skeletal muscle: a role for nitric oxide J Appl Physiol, March 1, 2003; 94(3): 935 - 940. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Sullivan, T. Doetschman, and J. B. Hoying Targeted disruption of the Fgf2 gene does not affect vascular growth in the mouse ischemic hindlimb J Appl Physiol, December 1, 2002; 93(6): 2009 - 2017. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Heil, T. Ziegelhoeffer, F. Pipp, S. Kostin, S. Martin, M. Clauss, and W. Schaper Blood monocyte concentration is critical for enhancement of collateral artery growth Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2411 - H2419. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Herzog, H. Sager, E. Khmelevski, A. Deylig, and W. D. Ito Collateral arteries grow from preexisting anastomoses in the rat hindlimb Am J Physiol Heart Circ Physiol, November 1, 2002; 283(5): H2012 - H2020. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Tuttle, T. L. Hahn, B. M. Sanders, F. A. Witzmann, S. J. Miller, M. C. Dalsing, and J. L. Unthank Impaired collateral development in mature rats Am J Physiol Heart Circ Physiol, July 1, 2002; 283(1): H146 - H155. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Rockstroh and B. G. Brown Coronary Collateral Size, Flow Capacity, and Growth: Estimates From the Angiogram in Patients With Obstructive Coronary Disease Circulation, January 15, 2002; 105(2): 168 - 173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Lloyd, H. T. Yang, and R. L. Terjung Arteriogenesis and angiogenesis in rat ischemic hindlimb: role of nitric oxide Am J Physiol Heart Circ Physiol, December 1, 2001; 281(6): H2528 - H2538. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Iglarz, J.-S. Silvestre, M. Duriez, D. Henrion, and B. I. Levy Chronic Blockade of Endothelin Receptors Improves Ischemia-Induced Angiogenesis in Rat Hindlimbs Through Activation of Vascular Endothelial Growth Factor-NO Pathway Arterioscler. Thromb. Vasc. Biol., October 1, 2001; 21(10): 1598 - 1603. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Wei, J. P. Erinjeri, C. M. Rovainen, and T. A. Woolsey Collateral Growth and Angiogenesis Around Cortical Stroke Stroke, September 1, 2001; 32(9): 2179 - 2184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Tuttle, R. D. Nachreiner, A. S. Bhuller, K. W. Condict, B. A. Connors, B. P. Herring, M. C. Dalsing, and J. L. Unthank Shear level influences resistance artery remodeling: wall dimensions, cell density, and eNOS expression Am J Physiol Heart Circ Physiol, September 1, 2001; 281(3): H1380 - H1389. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Simons Therapeutic coronary angiogenesis: a fronte praecipitium a tergo lupi? Am J Physiol Heart Circ Physiol, May 1, 2001; 280(5): H1923 - H1927. [Full Text] [PDF]
|
|
|
|
|
|
H. T. Yang, Z. Yan, J. A. Abraham, and R. L. Terjung VEGF121- and bFGF-induced increase in collateral blood flow requires normal nitric oxide production Am J Physiol Heart Circ Physiol, March 1, 2001; 280(3): H1097 - H1104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rodriguez-Porcel, A. Lerman, E. L. Ritman, S. H. Wilson, P. J. M. Best, and L. O. Lerman Altered Myocardial Microvascular 3D Architecture in Experimental Hypercholesterolemia Circulation, October 24, 2000; 102(17): 2028 - 2030. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. T. Yang, M. H. Laughlin, and R. L. Terjung Prior exercise training increases collateral-dependent blood flow in rats after acute femoral artery occlusion Am J Physiol Heart Circ Physiol, October 1, 2000; 279(4): H1890 - H1897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Simons, R. O. Bonow, N. A. Chronos, D. J. Cohen, F. J. Giordano, H. K. Hammond, R. J. Laham, W. Li, M. Pike, F. W. Sellke, et al. Clinical Trials in Coronary Angiogenesis: Issues, Problems, Consensus : An Expert Panel Summary Circulation, September 12, 2000; 102 (11): e73 - e86. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. T. Yang, Y. Feng, L. A. Allen, A. Protter, and R. L. Terjung Efficacy and specificity of bFGF increased collateral flow in experimental peripheral arterial insufficiency Am J Physiol Heart Circ Physiol, June 1, 2000; 278(6): H1966 - H1973. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D’Arcangelo, F. Facchiano, L. M. Barlucchi, G. Melillo, B. Illi, L. Testolin, C. Gaetano, and M. C. Capogrossi Acidosis Inhibits Endothelial Cell Apoptosis and Function and Induces Basic Fibroblast Growth Factor and Vascular Endothelial Growth Factor Expression Circ. Res., February 18, 2000; 86(3): 312 - 318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. T. Yang and Y. Feng bFGF increases collateral blood flow in aged rats with femoral artery ligation Am J Physiol Heart Circ Physiol, January 1, 2000; 278(1): H85 - H93. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. T. Hepple, T. L. Babits, M. J. Plyley, and J. M. Goodman Dissociation of peak vascular conductance and VO2 max among highly trained athletes J Appl Physiol, October 1, 1999; 87(4): 1368 - 1372. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Schaper and I. Buschmann Collateral Circulation and Diabetes Circulation, May 4, 1999; 99(17): 2224 - 2226. [Full Text] [PDF]
|
|
|
|
|
|
H. T. Yang, R. W. Ogilvie, and R. L. Terjung Exercise training enhances basic fibroblast growth factor-induced collateral blood flow Am J Physiol Heart Circ Physiol, June 1, 1998; 274(6): H2053 - H2061. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Deindl, I. Buschmann, I. E. Hoefer, T. Podzuweit, K. Boengler, S. Vogel, N. van Royen, B. Fernandez, and W. Schaper Role of Ischemia and of Hypoxia-Inducible Genes in Arteriogenesis After Femoral Artery Occlusion in the Rabbit Circ. Res., October 26, 2001; 89(9): 779 - 786. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
