AJP - Heart Myographs and Tissue organ baths
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 273: H511-H525, 1997;
0363-6135/97 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Roden, D. M.
Right arrow Articles by George, A. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Roden, D. M.
Right arrow Articles by George, A. L., Jr

AJP - Heart and Circulatory Physiology, Vol 273, Issue 2 511-H525, Copyright © 1997 by American Physiological Society

ARTICLES

Structure and function of cardiac sodium and potassium channels

D. M. Roden and A. L. George Jr
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-6602, USA.

The application of patch-clamp and molecular approaches has resulted in an increasingly refined understanding of the molecular entities underlying cardiac sodium and potassium currents. The sodium current results from expression of a single large alpha-subunit, whereas multiple potassium currents and potassium channel alpha-subunits have been identified. Recapitulation of some ion currents in heterologous expression systems requires not only expression of alpha-subunits but also ancillary (beta) subunits. Domains common to functions such as activation, inactivation, and drug block are now being identified in alpha- and beta-gene products. Variability in the expression or function of individual ion-channel genes is an increasingly recognized source of variability in the ion currents recorded in heart cells under physiological conditions (e.g. during development) as well as in disease.


This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
J. M. Nerbonne and R. S. Kass
Molecular Physiology of Cardiac Repolarization
Physiol Rev, October 1, 2005; 85(4): 1205 - 1253.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
R. Caballero, E. Delpón, C. Valenzuela, M. Longobardo, T. González, and J. Tamargo
Direct Effects of Candesartan and Eprosartan on Human Cloned Potassium Channels Involved in Cardiac Repolarization
Mol. Pharmacol., April 1, 2001; 59(4): 825 - 836.
[Abstract] [Full Text]

Home page
 Mol. Pharmacol.Home page
J. V. Steidl and A. J. Yool
Differential Sensitivity of Voltage-Gated Potassium Channels Kv1.5 and Kv1.2 to Acidic pH and Molecular Identification of pH Sensor
Mol. Pharmacol., May 1, 1999; 55(5): 812 - 820.
[Abstract] [Full Text]

Home page
 CirculationHome page
S. G. Priori, J. Barhanin, R. N. W. Hauer, W. Haverkamp, H. J. Jongsma, A. G. Kleber, W. J. McKenna, D. M. Roden, Y. Rudy, K. Schwartz, et al.
Genetic and Molecular Basis of Cardiac Arrhythmias: Impact on Clinical Management Part III
Circulation, February 9, 1999; 99(5): 674 - 681.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online