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Am J Physiol Heart Circ Physiol 272: H2869-H2874, 1997;
0363-6135/97 $5.00
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AJP - Heart and Circulatory Physiology, Vol 272, Issue 6 2869-H2874, Copyright © 1997 by American Physiological Society

ARTICLES

Left-to-right systolic and diastolic ventricular interactions are dependent on right ventricular volume

M. L. Dickstein, K. Todaka and D. Burkhoff
Department of Anesthesiology, Columbia University, New York, New York 10032, USA.

Three-compartment elastance modeling predicts that the magnitude of gain is solely dependent on the ratio of free wall and septal elastances. However, when nonlinearities in pressure-volume relationships are considered, the same model predicts that gain is load dependent. We therefore studied left-to-right ventricular interactions in the isolated cross-perfused canine heart preparation to determine whether, in fact, right ventricular volume modulates left-to-right ventricular interaction. We found that left-to-right systolic gain increased from 0.035 +/- 0.022 to 0.073 +/- 0.017 (P = 0.003) and left-to-right diastolic gain increased from 0.067 +/- 0.050 to 0.186 +/- 0.097 (P = 0.03) in response to increased right ventricular volume. This degree of volume dependency of gain is predicted by the three-compartment model when measured nonlinearities in time-varying elastance are taken into account. Future studies will need to account for changes in loading conditions when interpreting changes in systolic and diastolic interactions.


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A. E. Baker, R. Dani, E. R. Smith, J. V. Tyberg, and I. Belenkie
Quantitative assessment of independent contributions of pericardium and septum to direct ventricular interaction
Am J Physiol Heart Circ Physiol, August 1, 1998; 275(2): H476 - H483.
[Abstract] [Full Text] [PDF]


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