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Am J Physiol Heart Circ Physiol 272: H2859-H2868, 1997;
0363-6135/97 $5.00
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AJP - Heart and Circulatory Physiology, Vol 272, Issue 6 2859-H2868, Copyright © 1997 by American Physiological Society

ARTICLES

Uncoupling of local cerebral glucose metabolism and blood flow after acute fluid-percussion injury in rats

M. D. Ginsberg, W. Zhao, O. F. Alonso, J. Y. Loor-Estades, W. D. Dietrich and R. Busto
Neurotrauma Clinical Research Center, University of Miami School of Medicine, Florida 33101, USA.

We assessed local cerebral glucose metabolism (lCMRGlc) and blood flow (lCBF) interrelationships in the first hour after parasagittal fluid-percussion head injury (FPI) in rats. Matched series were studied autoradiographically for lCMRGlc and lCBF with 2-[14C]deoxyglucose and 14C-labeled iodoantipyrine, respectively. Three-dimensional autoradiographic-image mapping was to generate average data sets from which a mean ICMRGlc-to-lCBF ratio data set was derived. lCBF in neocortical regions ipsilateral to the trauma were depressed, on average, by 44% compared with sham-FPI rats, whereas contralateral lCBF values were not altered. By contrast, ICMRGlc was elevated in many cortical and subcortical sites of both hemispheres; this amounted to 1.3- to 1.4-fold increases in neocortical regions in the thalamus and 1.6- to 1.7-fold increases in the hippocampus. The lCMRGlc-to-lCBF ratio data revealed striking elevations both ipsilateral (P = 7 x 10(-7) and contralateral to the FPI (P = 0.003). The extent of metabolism-flow uncoupling, on average, amounted to 2.5-fold in the ipsilateral hippocampus and neocortex and 1.7-fold contralaterally. The loci of pronounced metabolism-flow dissociation corresponded closely to the previously documented histological distribution of neuronal necrosis. Our findings resemble events occurring in the acute focal ischemic penumbra and suggest that similar injury mechanisms may be operative.


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 Am. J. Physiol. Heart Circ. Physiol.Home page
M. J. Passineau, W. Zhao, R. Busto, W. D. Dietrich, O. Alonso, J. Y. Loor, H. M. Bramlett, and M. D. Ginsberg
Chronic metabolic sequelae of traumatic brain injury: prolonged suppression of somatosensory activation
Am J Physiol Heart Circ Physiol, September 1, 2000; 279(3): H924 - H931.
[Abstract] [Full Text] [PDF]


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