| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Heart and Circulatory Physiology, Vol 272, Issue 5 2337-H2342, Copyright © 1997 by American Physiological Society
ARTICLES |
W. G. Mayhan and K. P. Patel
Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha 68198-4575, USA.
Smoking is a primary risk factor in coronary and peripheral vascular disease. However, the precise component of cigarette smoke that contributes to the pathogenesis of vascular disease remains unclear. The goal of this study was to determine the effect of nicotine on endothelium-dependent dilatation of peripheral resistance arterioles in vivo. We measured the diameter of resistance arterioles (approximately 50 microns in diameter) contained within the microcirculation of the hamster cheek pouch in response to endothelium-dependent (acetylcholine and ADP) and -independent (nitroglycerin) agonists before and after an intravenous infusion of vehicle or two concentrations of nicotine. Acetylcholine, ADP, and nitroglycerin produced a dose-related dilatation of the cheek pouch arterioles under control conditions. Endothelium-dependent, but not -independent, dilatation of arterioles was modestly impaired by an infusion of a low concentration of nicotine (1.0 microgram.kg-1.min-1). Infusion of a higher concentration of nicotine (2 micrograms.kg-1.min-1), which increased the plasma level of nicotine to 14 +/- 1.6 ng/ml, produced a profound selective impairment in endothelium-dependent vasodilatation. We suggest that elevations in plasma nicotine may contribute to the pathogenesis of the peripheral vascular disease observed in smokers.
This article has been cited by other articles:
|
|
 |
|
  D. M. Arrick and W. G. Mayhan Acute infusion of nicotine impairs nNOS-dependent reactivity of cerebral arterioles via an increase in oxidative stress J Appl Physiol, December 1, 2007; 103(6): 2062 - 2067. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. V. Remillard, D. D. Tigno, O. Platoshyn, E. D. Burg, E. E. Brevnova, D. Conger, A. Nicholson, B. K. Rana, R. N. Channick, L. J. Rubin, et al. Function of Kv1.5 channels and genetic variations of KCNA5 in patients with idiopathic pulmonary arterial hypertension Am J Physiol Cell Physiol, May 1, 2007; 292(5): C1837 - C1853. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Fang, H. Sun, D. M. Arrick, and W. G. Mayhan Inhibition of NADPH oxidase improves impaired reactivity of pial arterioles during chronic exposure to nicotine J Appl Physiol, February 1, 2006; 100(2): 631 - 636. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Moccia, C. Frost, R. Berra-Romani, F. Tanzi, and D. J. Adams Expression and function of neuronal nicotinic ACh receptors in rat microvascular endothelial cells Am J Physiol Heart Circ Physiol, February 1, 2004; 286(2): H486 - H491. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Fang, H. Sun, and W. G. Mayhan Impairment of nitric oxide synthase-dependent dilatation of cerebral arterioles during infusion of nicotine Am J Physiol Heart Circ Physiol, February 1, 2003; 284(2): H528 - H534. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Zhang, Y. Liu, J. Shi, D. F. Larson, and R. R. Watson Side-Stream Cigarette Smoke Induces Dose-Response in Systemic Inflammatory Cytokine Production and Oxidative Stress Experimental Biology and Medicine, October 1, 2002; 227(9): 823 - 829. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. E. Black, N. Huang, P. C. Neligan, R. H. Levine, J. E. Lipa, S. Lintlop, C. R. Forrest, and C. Y. Pang Effect of nicotine on vasoconstrictor and vasodilator responses in human skin vasculature Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2001; 281(4): R1097 - R1104. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Gerzanich, F. Zhang, G. A. West, and J. M. Simard Chronic Nicotine Alters NO Signaling of Ca2+ Channels in Cerebral Arterioles Circ. Res., February 16, 2001; 88(3): 359 - 365. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. H. Tonnessen, S. R. Severson, R. D. Hurt, and V. M. Miller Modulation of Nitric-Oxide Synthase by Nicotine J. Pharmacol. Exp. Ther., November 1, 2000; 295(2): 601 - 606. [Abstract] [Full Text]
|
|
|
|
|
|
V. M. Miller, W. D. Clouse, B. H. Tonnessen, U. S. Boston, S. R. Severson, S. Bonde, K. S. Rud, and R. D. Hurt Time and dose effect of transdermal nicotine on endothelial function Am J Physiol Heart Circ Physiol, October 1, 2000; 279(4): H1913 - H1921. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. D. Clouse, H. Yamaguchi, M. R. Phillips, R. D. Hurt, L. A. Fitzpatrick, T. P. Moyer, C. Rowland, H. V. Schaff, and V. M. Miller Effects of transdermal nicotine treatment on structure and function of coronary artery bypass grafts J Appl Physiol, September 1, 2000; 89(3): 1213 - 1223. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W D. Clouse, K. S Rud, R. D Hurt, and V. M Miller Short-term treatment with transdermal nicotine affects the function of canine saphenous veins Vascular Medicine, May 1, 2000; 5(2): 75 - 82. [Abstract] [PDF]
|
|
|
|
|
|
W. G. Mayhan and G. M. Sharpe Chronic exposure to nicotine alters endothelium-dependent arteriolar dilatation: effect of superoxide dismutase J Appl Physiol, April 1, 1999; 86(4): 1126 - 1134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. G. Mayhan and G. M. Sharpe Superoxide dismutase restores endothelium-dependent arteriolar dilatation during acute infusion of nicotine J Appl Physiol, October 1, 1998; 85(4): 1292 - 1298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. G. Mayhan and G. M. Sharpe Nicotine impairs histamine-induced increases in macromolecular efflux: role of oxygen radicals J Appl Physiol, May 1, 1998; 84(5): 1589 - 1595. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
