AJP - Heart Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 272: H2313-H2319, 1997;
0363-6135/97 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Li, Z.
Right arrow Articles by Lakatta, E. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Li, Z.
Right arrow Articles by Lakatta, E. G.

AJP - Heart and Circulatory Physiology, Vol 272, Issue 5 2313-H2319, Copyright © 1997 by American Physiological Society

ARTICLES

Increased cardiomyocyte apoptosis during the transition to heart failure in the spontaneously hypertensive rat

Z. Li, O. H. Bing, X. Long, K. G. Robinson and E. G. Lakatta
Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.

The transition from compensated hypertrophy to failure in spontaneously hypertensive rats (SHR) of advanced age is associated with a marked increase in collagen, a reduction in myocyte mass, and a reduction in maximum Ca(2+)-activated myofibrillar force. We hypothesized that the reduction in myocyte mass and associated functional loss may be due to increased cell death by apoptosis. To test this hypothesis, we studied hearts from failing (SHR-F) and nonfailing SHR (SHR-NF) and age-matched Wistar-Kyoto rats (WKY). In addition, hearts from SHR-F that had been treated with an angiotensin-converting enzyme inhibitor (captopril) for an average of 27 days were also studied. Apoptotic cells were quantified in cross sections of myocardium by the terminal deoxynucleotidyltransferase- mediated 2'-deoxyuridine 5'-triphosphate nick end labeling technique. To identify the type of the cells undergoing apoptosis, sections were also stained for alpha-sarcomeric actin. Apoptotic cells were significantly increased in the SHR-F (38.92 +/- 12.79 vs. 8.05 +/- 3.98 cells/100,000 nuclei in SHR-NF; P < 0.05 and vs. 2.21 +/- 1.4 cells/100,000 nuclei in WKY; P < 0.01). Captopril treatment of SHR-F reduced the number of apoptotic cells to the level in SHR-NF (9.17 +/- 1.53 cells/100,000 nuclei; P < 0.01 vs. SHR-F). Most apoptotic cells were of cardiac myocyte origin. There was no significant difference in Bcl-2 protein expressed by hearts among the three groups. WAF-1 mRNA levels were increased in both SHR groups vs. WKY; in SHR-F, the density of WAF-1 mRNA was higher than in SHR-NF. Thus increased numbers of apoptotic cells are present in failing SHR hearts, suggesting that apoptosis might be a mechanism involved in the reduction of myocyte mass that accompanies the transition from stable compensation to heart failure in this model. Administration of the angiotensin-converting enzyme inhibitor captopril, which ameliorates heart failure in this model, is associated with a reduction in the exaggerated apoptosis that accompanies heart failure.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. K. Sharma, S. Dhingra, N. Khaper, and P. K. Singal
Activation of apoptotic processes during transition from hypertrophy to heart failure in guinea pigs
Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1384 - H1390.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
A. Diwan and G. W. Dorn II
Decompensation of Cardiac Hypertrophy: Cellular Mechanisms and Novel Therapeutic Targets
Physiology, February 1, 2007; 22(1): 56 - 64.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. Quadrilatero and J. W. E. Rush
Increased DNA fragmentation and altered apoptotic protein levels in skeletal muscle of spontaneously hypertensive rats
J Appl Physiol, October 1, 2006; 101(4): 1149 - 1161.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Z. Li, J. Y. Ma, I. Kerr, S. Chakravarty, S. Dugar, G. Schreiner, and A. A. Protter
Selective inhibition of p38{alpha} MAPK improves cardiac function and reduces myocardial apoptosis in rat model of myocardial injury
Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1972 - H1977.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
H. Han, H. Long, H. Wang, J. Wang, Y. Zhang, and Z. Wang
Progressive apoptotic cell death triggered by transient oxidative insult in H9c2 rat ventricular cells: a novel pattern of apoptosis and the mechanisms
Am J Physiol Heart Circ Physiol, June 1, 2004; 286(6): H2169 - H2182.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J.-J. Pang, R.-K. Xu, X.-B. Xu, J.-M. Cao, C. Ni, W.-L. Zhu, K. Asotra, M.-C. Chen, and C. Chen
Hexarelin protects rat cardiomyocytes from angiotensin II-induced apoptosis in vitro
Am J Physiol Heart Circ Physiol, March 1, 2004; 286(3): H1063 - H1069.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. A. Fortuno, A. Gonzalez, S. Ravassa, B. Lopez, and J. Diez
Clinical implications of apoptosis in hypertensive heart disease
Am J Physiol Heart Circ Physiol, May 1, 2003; 284(5): H1495 - H1506.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
P. Lee, M. Sata, D. J. Lefer, S. M. Factor, K. Walsh, and R. N. Kitsis
Fas pathway is a critical mediator of cardiac myocyte death and MI during ischemia-reperfusion in vivo
Am J Physiol Heart Circ Physiol, February 1, 2003; 284(2): H456 - H463.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. Jain, R. Liao, B. K. Podesser, S. Ngoy, C. S. Apstein, and F. R. Eberli
Influence of gender on the response to hemodynamic overload after myocardial infarction
Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2544 - H2550.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
M. R Bennett
APOPTOSIS IN THE CARDIOVASCULAR SYSTEM
Heart, May 1, 2002; 87(5): 480 - 487.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. T. A. Meij, F. Sheikh, S. K. Jimenez, P. W. Nickerson, E. Kardami, and P. A. Cattini
Exacerbation of myocardial injury in transgenic mice overexpressing FGF-2 is T cell dependent
Am J Physiol Heart Circ Physiol, February 1, 2002; 282(2): H547 - H555.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
A. Gonzalez, B. Lopez, S. Ravassa, R. Querejeta, M. Larman, J. Diez, and M. A. Fortuno
Stimulation of Cardiac Apoptosis in Essential Hypertension: Potential Role of Angiotensin II
Hypertension, January 1, 2002; 39(1): 75 - 80.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
M. A. Fortuno, S. Ravassa, A. Fortuno, G. Zalba, and J. Diez
Cardiomyocyte Apoptotic Cell Death in Arterial Hypertension: Mechanisms and Potential Management
Hypertension, December 1, 2001; 38(6): 1406 - 1412.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
L. Dalla Libera, B. Ravara, A. Angelini, K. Rossini, M. Sandri, G. Thiene, G. Battista Ambrosio, and G. Vescovo
Beneficial Effects on Skeletal Muscle of the Angiotensin II Type 1 Receptor Blocker Irbesartan in Experimental Heart Failure
Circulation, May 1, 2001; 103(17): 2195 - 2200.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
L. Barlucchi, A. Leri, D. E. Dostal, F. Fiordaliso, H. Tada, T. H. Hintze, J. Kajstura, B. Nadal-Ginard, and P. Anversa
Canine Ventricular Myocytes Possess a Renin-Angiotensin System That Is Upregulated With Heart Failure
Circ. Res., February 16, 2001; 88(3): 298 - 304.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
W.-Z. Zhu, M. Zheng, W. J. Koch, R. J. Lefkowitz, B. K. Kobilka, and R.-P. Xiao
Dual modulation of cell survival and cell death by beta 2-adrenergic signaling in adult mouse cardiac myocytes
PNAS, February 13, 2001; 98(4): 1607 - 1612.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
A. Frustaci, J. Kajstura, C. Chimenti, I. Jakoniuk, A. Leri, A. Maseri, B. Nadal-Ginard, and P. Anversa
Myocardial Cell Death in Human Diabetes
Circ. Res., December 8, 2000; 87(12): 1123 - 1132.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
S. Ravassa, M. A. Fortuno, A. Gonzalez, B. Lopez, G. Zalba, A. Fortuno, and J. Diez
Mechanisms of Increased Susceptibility to Angiotensin II-Induced Apoptosis in Ventricular Cardiomyocytes of Spontaneously Hypertensive Rats
Hypertension, December 1, 2000; 36(6): 1065 - 1071.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
T. E. McDonald, M. N. Grinman, C. M. Carthy, and K. R. Walley
Endotoxin infusion in rats induces apoptotic and survival pathways in hearts
Am J Physiol Heart Circ Physiol, November 1, 2000; 279(5): H2053 - H2061.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
A. Leri, F. Fiordaliso, M. Setoguchi, F. Limana, N. H. Bishopric, J. Kajstura, K. Webster, and P. Anversa
Inhibition of p53 Function Prevents Renin-Angiotensin System Activation and Stretch-Mediated Myocyte Apoptosis
Am. J. Pathol., September 1, 2000; 157(3): 843 - 857.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
B. H. Lorell and B. A. Carabello
Left Ventricular Hypertrophy : Pathogenesis, Detection, and Prognosis
Circulation, July 25, 2000; 102(4): 470 - 479.
[Full Text] [PDF]

Home page
 Circ. Res.Home page
P. M. Kang and S. Izumo
Apoptosis and Heart Failure : A Critical Review of the Literature
Circ. Res., June 9, 2000; 86(11): 1107 - 1113.
[Full Text] [PDF]

Home page
 Circ. Res.Home page
R. J. Hajjar, F. del Monte, T. Matsui, and A. Rosenzweig
Prospects for Gene Therapy for Heart Failure
Circ. Res., March 31, 2000; 86(6): 616 - 621.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
P. Madeddu, C. Emanueli, R. Maestri, M. B. Salis, A. Minasi, M. C. Capogrossi, and G. Olivetti
Angiotensin II Type 1 Receptor Blockade Prevents Cardiac Remodeling in Bradykinin B2 Receptor Knockout Mice
Hypertension, January 1, 2000; 35(1): 391 - 396.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
C. Emanueli, R. Maestri, D. Corradi, R. Marchione, A. Minasi, M. G. Tozzi, M. B. Salis, S. Straino, M. C. Capogrossi, G. Olivetti, et al.
Dilated and Failing Cardiomyopathy in Bradykinin B2 Receptor Knockout Mice
Circulation, December 7, 1999; 100(23): 2359 - 2365.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
D. Ekhterae, Z. Lin, M. S. Lundberg, M. T. Crow, F. C. Brosius III, and G. Nunez
ARC Inhibits Cytochrome c Release From Mitochondria and Protects Against Hypoxia-Induced Apoptosis in Heart-Derived H9c2 Cells
Circ. Res., December 3, 1999; 85 (12): e70 - e77.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
S. Guerra, A. Leri, X. Wang, N. Finato, C. Di Loreto, C. A. Beltrami, J. Kajstura, and P. Anversa
Myocyte Death in the Failing Human Heart Is Gender Dependent
Circ. Res., October 29, 1999; 85(9): 856 - 866.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
B.-S. Tea, T.-V. Dam, P. Moreau, P. Hamet, and D. deBlois
Apoptosis During Regression of Cardiac Hypertrophy in Spontaneously Hypertensive Rats : Temporal Regulation and Spatial Heterogeneity
Hypertension, August 1, 1999; 34(2): 229 - 235.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
E. Iwai-Kanai, K. Hasegawa, M. Araki, T. Kakita, T. Morimoto, and S. Sasayama
{alpha}- and {beta}-Adrenergic Pathways Differentially Regulate Cell Type–Specific Apoptosis in Rat Cardiac Myocytes
Circulation, July 20, 1999; 100(3): 305 - 311.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
G. Condorelli, C. Morisco, G. Stassi, A. Notte, F. Farina, G. Sgaramella, A. de Rienzo, R. Roncarati, B. Trimarco, and G. Lembo
Increased Cardiomyocyte Apoptosis and Changes in Proapoptotic and Antiapoptotic Genes bax and bcl-2 During Left Ventricular Adaptations to Chronic Pressure Overload in the Rat
Circulation, June 15, 1999; 99(23): 3071 - 3078.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
M. A. Fortuno, G. Zalba, S. Ravassa, E. D'Elom, F. J. Beaumont, A. Fortuno, and J. Diez
p53-Mediated Upregulation of BAX Gene Transcription Is Not Involved in Bax-{alpha} Protein Overexpression in the Left Ventricle of Spontaneously Hypertensive Rats
Hypertension, June 1, 1999; 33(6): 1348 - 1352.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
B. Li, M. Setoguchi, X. Wang, A. M. Andreoli, A. Leri, A. Malhotra, J. Kajstura, and P. Anversa
Insulin-Like Growth Factor-1 Attenuates the Detrimental Impact of Nonocclusive Coronary Artery Constriction on the Heart
Circ. Res., May 14, 1999; 84(9): 1007 - 1019.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Malhotra and F. C. Brosius III
Glucose Uptake and Glycolysis Reduce Hypoxia-induced Apoptosis in Cultured Neonatal Rat Cardiac Myocytes
J. Biol. Chem., April 30, 1999; 274(18): 12567 - 12575.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
A. Frustaci, C. Chimenti, M. Setoguchi, S. Guerra, S. Corsello, F. Crea, A. Leri, J. Kajstura, P. Anversa, and A. Maseri
Cell Death in Acromegalic Cardiomyopathy
Circulation, March 23, 1999; 99(11): 1426 - 1434.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
C. Communal, K. Singh, D. R. Pimentel, and W. S. Colucci
Norepinephrine Stimulates Apoptosis in Adult Rat Ventricular Myocytes by Activation of the ß-Adrenergic Pathway
Circulation, September 29, 1998; 98(13): 1329 - 1334.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Y. Shizukuda, P. M. Buttrick, D. L. Geenen, A. C. Borczuk, R. N. Kitsis, and E. H. Sonnenblick
beta -Adrenergic stimulation causes cardiocyte apoptosis: influence of tachycardia and hypertrophy
Am J Physiol Heart Circ Physiol, September 1, 1998; 275(3): H961 - H968.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Goussev, V. G. Sharov, H. Shimoyama, M. Tanimura, M. Lesch, S. Goldstein, and H. N. Sabbah
Effects of ACE inhibition on cardiomyocyte apoptosis in dogs with heart failure
Am J Physiol Heart Circ Physiol, August 1, 1998; 275(2): H626 - H631.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
M. A. Fortuno, S. Ravassa, J. C. Etayo, and J. Diez
Overexpression of Bax Protein and Enhanced Apoptosis in the Left Ventricle of Spontaneously Hypertensive Rats : Effects of AT1 Blockade With Losartan
Hypertension, August 1, 1998; 32(2): 280 - 286.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
W. W. Brooks, O. H. L. Bing, C. H. Conrad, L. O'Neill, M. T. Crow, E. G. Lakatta, D. E. Dostal, K. M. Baker, and M. O. Boluyt
Captopril Modifies Gene Expression in Hypertrophied and Failing Hearts of Aged Spontaneously Hypertensive Rats
Hypertension, December 1, 1997; 30(6): 1362 - 1368.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
C. Communal, W. S. Colucci, and K. Singh
p38 Mitogen-activated Protein Kinase Pathway Protects Adult Rat Ventricular Myocytes against beta -Adrenergic Receptor-stimulated Apoptosis. EVIDENCE FOR Gi-DEPENDENT ACTIVATION
J. Biol. Chem., June 16, 2000; 275(25): 19395 - 19400.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. Condorelli, R. Roncarati, J. Ross Jr., A. Pisani, G. Stassi, M. Todaro, S. Trocha, A. Drusco, Y. Gu, M. A. Russo, et al.
Heart-targeted overexpression of caspase3 in mice increases infarct size and depresses cardiac function
PNAS, August 14, 2001; 98(17): 9977 - 9982.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
T. Kakita, K. Hasegawa, E. Iwai-Kanai, S. Adachi, T. Morimoto, H. Wada, T. Kawamura, T. Yanazume, and S. Sasayama
Calcineurin Pathway Is Required for Endothelin-1-Mediated Protection Against Oxidant Stress-Induced Apoptosis in Cardiac Myocytes
Circ. Res., June 22, 2001; 88(12): 1239 - 1246.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online