AJP - Heart and Circulatory Physiology, Vol 272, Issue 3 1205-H1211, Copyright © 1997 by American Physiological Society
Effect of reperfusion on ventricular mass, topography, and function during healing of anterior infarction
B. I. Jugdutt
Department of Medicine, University of Alberta, Edmonton, Canada.
The effect of reperfusion performed 2 h after left anterior descending
coronary artery occlusion on in vivo changes (echocardiograms) in
ventricular mass, topography, and function during postinfarction healing
over 6 wk and postmortem topography (planimetry) and collagen
(hydroxyproline) content at 6 wk were measured in dogs randomized to
reperfusion (n = 12) and no reperfusion (n = 12). Compared with no
reperfusion over the 6 wk, reperfusion resulted in less increase in
systolic and diastolic volumes, less increase in ventricular mass, less
infarct wall thinning, and mild improvement in global ejection fraction
without any change in regional asynergy. Although reperfusion decreased the
infarct collagen content at 6 wk, it reduced the in vivo expansion of the
endocardial surface area; the elongation, diastolic bulge, echogenicity,
and systolic thinning of the infarct zone; and the global shape index and
aneurysm frequency. Thus reperfusion after 2 h attenuates regional and
global dilation and produces less increase in mass during postinfarct
healing than no reperfusion, so that the improvement in global systolic
function cannot be attributed to global hypertrophy.
