AJP - Heart and Circulatory Physiology, Vol 272, Issue 3 1094-H1099, Copyright © 1997 by American Physiological Society

ARTICLES

Relationship between diabetic autonomic dysfunction and heart rate variability assessed by recurrence plot

D. Mestivier, N. P. Chau, X. Chanudet, B. Bauduceau and P. Larroque
Institut National de la Sante et de la Recherche Medicale U444, Universite Paris 7-Denis Diderot, France.

Beat-to-beat heart rate (HR) and blood pressure were measured by the Finapres system in 44 healthy and 64 diabetic subjects in the at-rest condition. Autonomic control in diabetic subjects was assessed by the Ewing test. HR variability was explored by both linear and nonlinear methods. Linear methods used HR standard deviation and power spectrum. The percentage of the spectrum in the low frequencies was used to assess the sympathetic tone of the autonomic control. The nonlinear method used the "recurrence plot." This method explored long parallel subsequences in the HR time series. These sequences characterize the dependence of the HR dynamics on initial values. The HR standard deviation was reduced in the diabetic subjects compared with the healthy subjects (2.80 +/- 1.17 vs. 3.64 +/- 1.45 beats/min; P < 0.001). In the diabetic subjects, the HR standard deviation and the percentage of the spectrum in the low frequencies showed no correlations with the Ewing score (P > 0.10). In contrast, the longest length index was very strongly correlated to the Ewing score (r = -0.60; P < 0.0001). The results suggest that nonlinear methods might be powerful to explore the autonomic dysfunction in diabetic subjects.

This article has been cited by other articles:

				A. Schumacher Linear and Nonlinear Approaches to the Analysis of R-R Interval Variability Biol Res Nurs, January 1, 2004; 5(3): 211 - 221. [Abstract] [PDF]

				D. Mestivier, H. Dabire, and N. P. Chau Effects of autonomic blockers on linear and nonlinear indexes of blood pressure and heart rate in SHR Am J Physiol Heart Circ Physiol, September 1, 2001; 281(3): H1113 - H1121. [Abstract] [Full Text] [PDF]

				H. Dabire, D. Mestivier, J. Jarnet, M. E. Safar, and N. P. Chau Quantification of sympathetic and parasympathetic tones by nonlinear indexes in normotensive rats Am J Physiol Heart Circ Physiol, October 1, 1998; 275(4): H1290 - H1297. [Abstract] [Full Text] [PDF]

				A. Giuliani, G. Piccirillo, V. Marigliano, and A. Colosimo A nonlinear explanation of aging-induced changes in heartbeat dynamics Am J Physiol Heart Circ Physiol, October 1, 1998; 275(4): H1455 - H1461. [Abstract] [Full Text] [PDF]

				D. Mestivier, H. Dabire, M. Safar, and N. P. Chau Use of nonlinear methods to assess effects of clonidine on blood pressure in spontaneously hypertensive rats J Appl Physiol, May 1, 1998; 84(5): 1795 - 1800. [Abstract] [Full Text] [PDF]