AJP - Heart Calcium Transients and Cell-Sarcomere
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 272: H706-H713, 1997;
0363-6135/97 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by VanTeeffelen, J. W.
Right arrow Articles by Spaan, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by VanTeeffelen, J. W.
Right arrow Articles by Spaan, J. A.

AJP - Heart and Circulatory Physiology, Vol 272, Issue 2 706-H713, Copyright © 1997 by American Physiological Society

ARTICLES

Changes in myocardial fluid filtration are reflected in epicardial lymph pressure

J. W. VanTeeffelen, D. Merkus, I. Vergroesen and J. A. Spaan
Department of Medical Physics, Academic Medical Center, University of Amsterdam, The Netherlands.

The effect of increased fluid filtration on stopped-flow epicardial lymph pressure (P(lymph)), used as an indicator of myocardial interstitial volume, was investigated in the anesthetized open-chest dog. Histamine infusion resulted in an increased systolic peak in the P(lymph) signal together with an increase in diastolic P(lymph) in four of five animals. During reactive hyperemia, systolic and diastolic P(lymph) increased to 127 +/- 8 and 121 +/- 6.7% (mean +/- SE, n = 6) of control, respectively. Peak P(lymph) was approximately 15 s later than peak coronary blood flow and venous pressure (P(ven)). When P(ven) was transiently elevated to 367 +/- 72 (systolic) and 247 +/- 45% (diastolic) of control, P(lymph) increased to 132 +/- 12 and 120 +/- 5.5% of control. The time of response was similar for P(ven) and P(lymph) (t50 approximately 2 S). The increased systolic and diastolic P(lymph) can be explained by an increase in interstitial and lymph filling. It is concluded that changes in myocardial fluid filtration are reflected in epicardial P(lymph). Furthermore, it seems that cardiac contraction constitutes an important defense mechanism against the formation of myocardial edema.


This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
N. Westerhof, C. Boer, R. R. Lamberts, and P. Sipkema
Cross-talk between cardiac muscle and coronary vasculature.
Physiol Rev, October 1, 2006; 86(4): 1263 - 1308.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. W. G. E. VanTeeffelen, S. Dekker, D. S. Fokkema, M. Siebes, H. Vink, and J. A. E. Spaan
Hyaluronidase treatment of coronary glycocalyx increases reactive hyperemia but not adenosine hyperemia in dog hearts
Am J Physiol Heart Circ Physiol, December 1, 2005; 289(6): H2508 - H2513.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. S. Fokkema, J. W. G. E. VanTeeffelen, S. Dekker, I. Vergroesen, J. B. Reitsma, and J. A. E. Spaan
Diastolic time fraction as a determinant of subendocardial perfusion
Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2450 - H2456.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. W. G. E. Vanteeffelen, D. Merkus, L. J. Bos, I. Vergroesen, and J. A. E. Spaan
Impairment of contraction increases sensitivity of epicardial lymph pressure for left ventricular pressure
Am J Physiol Heart Circ Physiol, January 1, 1998; 274(1): H187 - H192.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online