| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Heart and Circulatory Physiology, Vol 271, Issue 6 2520-H2528, Copyright © 1996 by American Physiological Society
ARTICLES |
D. O. Bates and F. E. Curry
Department of Human Physiology, School of Medicine, University of California, Davis 95616, USA.
These experiments report the first direct measurement of microvessel permeability coefficients after exposure to vascular endothelial growth factor (VEGF). The Landis technique was extended to enable measurement of the resistance of the microvessel wall to water flow, hydraulic conductivity (Lp), on the same microvessel in the frog mesentery during the initial exposure to VEGF (acute) and 24 and 72 h after initial exposure (chronic). Control measurements of Lp showed no change either acutely or chronically. Exposure to 1 nM VEGF rapidly and transiently increased microvessel Lp within 30 s (to 7.8-fold greater than baseline values) and returned to control within 2 min. The baseline Lp was fivefold greater after 24 h than the initial baseline as a result of VEGF perfusion and returned to its original value after 72 h. These experiments confirm the hypothesis that VEGF acts both acutely (over a period of a few minutes) and chronically (over a few hours) to increase microvascular permeability.
This article has been cited by other articles:
|
|
 |
|
  J. W. Breslin, N. Gaudreault, K. D. Watson, R. Reynoso, S. Y. Yuan, and M. H. Wu Vascular endothelial growth factor-C stimulates the lymphatic pump by a VEGF receptor-3-dependent mechanism Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H709 - H718. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Mehta and A. B. Malik Signaling Mechanisms Regulating Endothelial Permeability Physiol Rev, January 1, 2006; 86(1): 279 - 367. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Glass, T. M. Pocock, F. E. Curry, and D. O. Bates Cytosolic Ca2+ concentration and rate of increase of the cytosolic Ca2+ concentration in the regulation of vascular permeability in Rana in vivo J. Physiol., May 1, 2005; 564(3): 817 - 827. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. R. Foster, M. A. Saleem, P. W. Mathieson, D. O. Bates, and S. J. Harper Vascular endothelial growth factor and nephrin interact and reduce apoptosis in human podocytes Am J Physiol Renal Physiol, January 1, 2005; 288(1): F48 - F57. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Pocock, R. R. Foster, and D. O. Bates Evidence of a role for TRPC channels in VEGF-mediated increased vascular permeability in vivo Am J Physiol Heart Circ Physiol, March 1, 2004; 286(3): H1015 - H1026. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. E. Curry, M. Zeng, and R. H. Adamson Thrombin increases permeability only in venules exposed to inflammatory conditions Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2446 - H2453. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. O. Bates and R. O. P. Jones The Role of Vascular Endothelial Growth Factor in Wound Healing International Journal of Lower Extremity Wounds, June 1, 2003; 2(2): 107 - 120. [Abstract] [PDF]
|
|
|
|
|
|
B. M. Fu and S. Shen Structural mechanisms of acute VEGF effect on microvessel permeability Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H2124 - H2135. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. R. Foster, R. Hole, K. Anderson, S. C. Satchell, R. J. Coward, P. W. Mathieson, D. A. Gillatt, M. A. Saleem, D. O. Bates, and S. J. Harper Functional evidence that vascular endothelial growth factor may act as an autocrine factor on human podocytes Am J Physiol Renal Physiol, June 1, 2003; 284(6): F1263 - F1273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Glass and D. O. Bates Role of endothelial Ca2+ stores in the regulation of hydraulic conductivity of Rana microvessels in vivo Am J Physiol Heart Circ Physiol, April 1, 2003; 284(4): H1468 - H1478. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Ferrara Role of vascular endothelial growth factor in regulation of physiological angiogenesis Am J Physiol Cell Physiol, June 1, 2001; 280(6): C1358 - C1366. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Clauss, C. Sunderkotter, B. Sveinbjornsson, S. Hippenstiel, A. Willuweit, M. Marino, E. Haas, R. Seljelid, P. Scheurich, N. Suttorp, et al. A permissive role for tumor necrosis factor in vascular endothelial growth factor-induced vascular permeability Blood, March 1, 2001; 97(5): 1321 - 1329. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Lakshminarayanan, D. A. Antonetti, T. W. Gardner, and J. M. Tarbell Effect of VEGF on Retinal Microvascular Endothelial Hydraulic Conductivity: The Role of NO Invest. Ophthalmol. Vis. Sci., December 1, 2000; 41(13): 4256 - 4261. [Abstract] [Full Text]
|
|
|
|
|
|
T. M. Pocock, B. Williams, F. E. Curry, and D. O. Bates VEGF and ATP act by different mechanisms to increase microvascular permeability and endothelial [Ca2+]i Am J Physiol Heart Circ Physiol, October 1, 2000; 279(4): H1625 - H1634. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. Senger and L. Van De Water VEGF Expression by Epithelial and Stromal Cell Compartments : Resolving a Controversy Am. J. Pathol., July 1, 2000; 157(1): 1 - 3. [Full Text] [PDF]
|
|
|
|
|
|
C. C. Michel and F. E. Curry Microvascular Permeability Physiol Rev, July 1, 1999; 79(3): 703 - 761. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. G. Mayhan VEGF increases permeability of the blood-brain barrier via a nitric oxide synthase/cGMP-dependent pathway Am J Physiol Cell Physiol, May 1, 1999; 276(5): C1148 - C1153. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hippenstiel, M. Krull, A. Ikemann, W. Risau, M. Clauss, and N. Suttorp VEGF induces hyperpermeability by a direct action on endothelial cells Am J Physiol Lung Cell Mol Physiol, May 1, 1998; 274(5): L678 - L684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Hood, C. J. Meininger, M. Ziche, and H. J. Granger VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells Am J Physiol Heart Circ Physiol, March 1, 1998; 274(3): H1054 - H1058. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Hossain, C. M. L. Bouton, J. Pevsner, and J. Laterra Induction of Vascular Endothelial Growth Factor in Human Astrocytes by Lead. INVOLVEMENT OF A PROTEIN KINASE C/ACTIVATOR PROTEIN-1 COMPLEX-DEPENDENT AND HYPOXIA-INDUCIBLE FACTOR 1-INDEPENDENT SIGNALING PATHWAY J. Biol. Chem., September 1, 2000; 275(36): 27874 - 27882. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
