AJP - Heart Calcium Transients and Cell-Sarcomere
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Am J Physiol Heart Circ Physiol 271: H435-H439, 1996;
0363-6135/96 $5.00
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AJP - Heart and Circulatory Physiology, Vol 271, Issue 2 435-H439, Copyright © 1996 by American Physiological Society

ARTICLES

Parasympathetic denervation supersensitivity of the transplanted human ventricle in vivo

J. Koglin, P. Uberfuhr and W. von Scheidt
Medizinische Klinik I, Klinikum Grosshadern, University of Munich, Germany.

Sympathetic inotropic supersensitivity after transplantation-associated denervation of the cardiac autonomic nervous system has been described in humans previously. Potential changes of the parasympathetic regulation of the human ventricular contractility have not been investigated yet. We studied the antiadrenergic, negative inotropic effect of carbachol (3.6 micrograms/kg) during continuous beta-adrenergic stimulation (with isoproterenol, 20 ng.kg-1.min-1) in seven heart transplant recipients and seven healthy controls. Changes in ventricular contractility were calculated as increase of the systolic pressure-to-dimension ratio (delta P/D) and the rate-corrected velocity of circumferential fiber shortening (delta Vcfc), using M-mode echocardiography. In the control group, the isoproterenol-induced increase in contractility was attenuated only insignificantly by carbachol [delta P/D from 1.53 +/- 0.53 to 0.81 +/- 0.55 mmHg/mm, delta Vcfc from 0.77 +/- 0.20 to 0.63 +/- 0.22% x square root of beats/min (bpm)/ms]. In contrast, the transplant group exhibited a significant reduction of the isoproterenol-induced increase in contractility [delta P/D from 1.27 +/- 0.71 to -0.81 +/- 0.51 mmHg/mm (P < 0.01), delta Vcfc from 1.04 +/- 0.84 to 0.04 +/- 0.43% x square root of bpm/ms (P < 0.01)]. These data are consistent with parasympathetic indirect negative inotropic supersensitivity of the transplanted human heart in vivo.


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Deficiency of M2 muscarinic acetylcholine receptors increases susceptibility of ventricular function to chronic adrenergic stress
Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H810 - H820.
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