AJP - Heart and Circulatory Physiology, Vol 271, Issue 1 303-H310, Copyright © 1996 by American Physiological Society

ARTICLES

Diurnal heart rate variability in healthy subjects: effects of aging and sex difference

Y. Yamasaki, M. Kodama, M. Matsuhisa, M. Kishimoto, H. Ozaki, A. Tani, N. Ueda, Y. Ishida and T. Kamada
First Department of Medicine, Osaka University School of Medicine, Japan.

To study the effects of aging and gender, circadian profiles of heart rate variability were evaluated for 105 healthy volunteers by frequency domain analysis of a Holter electrocardiogram record. The low-frequency (LF) component representing cardiac beta-adrenergic function showed high values for the 0800-1200 period in male subjects and the 1200-2400 period in female subjects. The high-frequency (HF) component representing parasympathetic function showed a peak for the 0000-0600 period in both male and female subjects independent of age. Male subjects showed significantly higher %LF [LF/(LF + HF) x 100] than female subjects. LF showed consistently highly significant correlation with age. These basic findings can help elucidate the diurnal profile of cardiac nerve function and how it is affected by aging and sex difference.

This article has been cited by other articles:

				M. Takagi, Y. Tanaka, Y. Yamasaki, M. Yamamoto, M. Hori, T. Nakaniwa, M. Niwa, H. Uchino, Y. Tamura, T. Nomiyama, et al. Responsiveness of insulin-induced cardiac sympathetic nerve activation associates with blood pressure regulation in diabetics Am J Physiol Endocrinol Metab, May 1, 2003; 284(5): E1022 - E1026. [Abstract] [Full Text] [PDF]

				J. M. Evans, M. G. Ziegler, A. R. Patwardhan, J. B. Ott, C. S. Kim, F. M. Leonelli, and C. F. Knapp Gender differences in autonomic cardiovascular regulation: spectral, hormonal, and hemodynamic indexes J Appl Physiol, December 1, 2001; 91(6): 2611 - 2618. [Abstract] [Full Text] [PDF]

				M. Emdin, A. Gastaldelli, E. Muscelli, A. Macerata, A. Natali, S. Camastra, and E. Ferrannini Hyperinsulinemia and Autonomic Nervous System Dysfunction in Obesity : Effects of Weight Loss Circulation, January 30, 2001; 103(4): 513 - 519. [Abstract] [Full Text] [PDF]

				V. Crasset, S. Mezzetti, M. Antoine, P. Linkowski, J. P. Degaute, and P. van de Borne Effects of Aging and Cardiac Denervation on Heart Rate Variability During Sleep Circulation, January 2, 2001; 103(1): 84 - 88. [Abstract] [Full Text] [PDF]

				S. Sakata, J. Hayano, S. Mukai, A. Okada, and T. Fujinami Aging and spectral characteristics of the nonharmonic component of 24-h heart rate variability Am J Physiol Regulatory Integrative Comp Physiol, June 1, 1999; 276(6): R1724 - R1731. [Abstract] [Full Text] [PDF]

				M. P. Tulppo, T. H. Makikallio, T. Seppanen, R. T. Laukkanen, and H. V. Huikuri Vagal modulation of heart rate during exercise: effects of age and physical fitness Am J Physiol Heart Circ Physiol, February 1, 1998; 274(2): H424 - H429. [Abstract] [Full Text] [PDF]