| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Heart and Circulatory Physiology, Vol 271, Issue 1 282-H287, Copyright © 1996 by American Physiological Society
ARTICLES |
H. Suzuki, Y. Noda, X. P. Gao, F. Sejourne, H. Alkan-Onyuksel, S. Paul and I. Rubinstein
Department of Medicine, University of Illinois at Chicago 60612, USA.
The purpose of this study was to determine whether vasoactive intestinal peptide (VIP) elicits vasodilation in the in situ peripheral microcirculation of hamsters with spontaneous hypertension and whether encapsulation of VIP into liposomes modulates this response. Using intravital microscopy, we found that suffusion of VIP (0.05 and 0.1 nmol) alone over cheek pouch resistance arterioles of normotensive hamsters elicited significant vasodilation that was potentiated and prolonged by encapsulation of the peptide into liposomes (P < 0.05). By contrast, VIP (0.5 and 0.1 nmol) had no significant effects on arteriolar diameter in hamsters with spontaneous hypertension. However, encapsulation of VIP into liposomes restored its vasorelaxant effects in hypertensive animals, although the duration of vasodilation was significantly shorter in comparison with controls (P < 0.05). Empty liposomes had no significant effects on arteriolar diameter in either group. These data indicate that VIP-induced vasodilation in the peripheral microcirculation in situ is impaired in essential hypertension and that encapsulation of VIP into liposomes restores, in part, this response.
This article has been cited by other articles:
|
|
 |
|
  T. Tsueshita, S. Gandhi, H. Onyuksel, and I. Rubinstein Phospholipids modulate the biophysical properties and vasoactivity of PACAP-(138) J Appl Physiol, October 1, 2002; 93(4): 1377 - 1383. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Suzuki, H. Ikezaki, D. Hong, and I. Rubinstein PGH2-TxA2-receptor blockade restores vasoreactivity in a new rodent model of genetic hypertension J Appl Physiol, June 1, 2000; 88(6): 1983 - 1988. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ikezaki, M. Patel, H. Onyuksel, S. R. Akhter, X.-P. Gao, and I. Rubinstein Exogenous calmodulin potentiates vasodilation elicited by phospholipid-associated VIP in vivo Am J Physiol Regulatory Integrative Comp Physiol, May 1, 1999; 276(5): R1359 - R1365. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ikezaki, H. Onyuksel, and I. Rubinstein Liposomal VIP attenuates phenylephrine- and ANG II-induced vasoconstriction in vivo Am J Physiol Regulatory Integrative Comp Physiol, August 1, 1998; 275(2): R588 - R595. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ikezaki, S. Paul, H. Alkan-Onyuksel, M. Patel, X.-P. Gao, and I. Rubinstein Vasodilation elicited by liposomal VIP is unimpeded by anti-VIP antibody in hamster cheek pouch Am J Physiol Regulatory Integrative Comp Physiol, July 1, 1998; 275(1): R56 - R62. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Gololobov, Y. Noda, S. Sherman, I. Rubinstein, J. Baranowska-Kortylewicz, and S. Paul Stabilization of Vasoactive Intestinal Peptide by Lipids J. Pharmacol. Exp. Ther., May 1, 1998; 285(2): 753 - 758. [Abstract] [Full Text]
|
|
|
|
 |
|
 C. L. Thomas, J. E. Artwohl, H. Suzuki, X.-p. Gao, E. White, A. Saroli, R. M. Bunte, and I. Rubinstein Initial Characterization of Hamsters With Spontaneous Hypertension Hypertension, August 1, 1997; 30(2): 301 - 304. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
