AJP - Heart and Circulatory Physiology, Vol 270, Issue 4 1407-H1413, Copyright © 1996 by American Physiological Society

ARTICLES

Sequential ischemia/reperfusion results in contralateral skeletal muscle salvage

S. K. Liauw, B. B. Rubin, T. F. Lindsay, A. D. Romaschin and P. M. Walker
R. Fraser Elliot Laboratory, Department of Vascular Surgery, University of Toronto, Toronto Hospital, Ontario, Canada.

Sequential ischemia/reperfusion in a paired canine gracilis muscle model resulted in significant muscle salvage. In this model, one randomly chosen gracilis muscle was subjected to 5 h of ischemia followed by 48 h of in vivo reperfusion. The contralateral (second) muscle was then made ischemic and reperfused using the same protocol. Muscle necrosis was determined at the end of 48 h of reperfusion. A mean 60% reduction in muscle necrosis was observed in the second group of muscles. Analysis of tissue adenine nucleotides indicated that significant sparing of ATP utilization occurred in the second muscle group during ischemia. Preliminary analysis of tissue heat shock proteins (HSP) showed that the second group of muscles had a different pattern of HSP expression before the onset of ischemia. The results suggest that reduced ATP utilization and altered HSP expression in the second muscle play a role in the tissue salvage observed in this sequential muscle ischemia model.

This article has been cited by other articles:

				P. D. Addison, P. C. Neligan, H. Ashrafpour, A. Khan, A. Zhong, M. Moses, C. R. Forrest, and C. Y. Pang Noninvasive remote ischemic preconditioning for global protection of skeletal muscle against infarction Am J Physiol Heart Circ Physiol, October 1, 2003; 285(4): H1435 - H1443. [Abstract] [Full Text] [PDF]

				E. W. Dickson, R. J. Tubbs, W. A. Porcaro, W. J. Lee, D. J. Blehar, R. E. Carraway, C. E. Darling, and K. Przyklenk Myocardial preconditioning factors evoke mesenteric ischemic tolerance via opioid receptors and KATP channels Am J Physiol Heart Circ Physiol, July 1, 2002; 283(1): H22 - H28. [Abstract] [Full Text] [PDF]

				E. W. Dickson, M. Lorbar, W. A. Porcaro, R. A. Fenton, C. P. Reinhardt, A. Gysembergh, and K. Przyklenk Rabbit heart can be "preconditioned" via transfer of coronary effluent Am J Physiol Heart Circ Physiol, December 1, 1999; 277(6): H2451 - H2457. [Abstract] [Full Text] [PDF]

				T. J. Pell, G. F. Baxter, D. M. Yellon, and G. M. Drew Renal ischemia preconditions myocardium: role of adenosine receptors and ATP-sensitive potassium channels Am J Physiol Heart Circ Physiol, November 1, 1998; 275(5): H1542 - H1547. [Abstract] [Full Text] [PDF]

				T. Oxman, M. Arad, R. Klein, N. Avazov, and B. Rabinowitz Limb ischemia preconditions the heart against reperfusion tachyarrhythmia Am J Physiol Heart Circ Physiol, October 1, 1997; 273(4): H1707 - H1712. [Abstract] [Full Text] [PDF]

				Y. Birnbaum, S. L. Hale, and R. A. Kloner Ischemic Preconditioning at a Distance : Reduction of Myocardial Infarct Size by Partial Reduction of Blood Supply Combined With Rapid Stimulation of the Gastrocnemius Muscle in the Rabbit Circulation, September 2, 1997; 96(5): 1641 - 1646. [Abstract] [Full Text]