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Am J Physiol Heart Circ Physiol 259: H1809-H1812, 1990;
0363-6135/90 $5.00
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AJP - Heart and Circulatory Physiology, Vol 259, Issue 6 1809-H1812, Copyright © 1990 by American Physiological Society

ARTICLES

Neutrophils accumulate and contribute to skeletal muscle dysfunction after ischemia-reperfusion

D. L. Walden, H. J. McCutchan, E. G. Enquist, J. R. Schwappach, P. F. Shanley, O. K. Reiss, L. S. Terada, J. A. Leff and J. E. Repine
Webb-Waring Lung Institute, University of Colorado Health Science Center, Denver 80262.

Skeletal muscles subjected to ischemia and then reperfusion develop contractile dysfunction for reasons that are unclear. We found that rats pretreated with vinblastine 4 days before study had decreased numbers of blood neutrophils and increased gastrocnemius muscle function after ischemia (3h) and reperfusion (4 h) compared with untreated rats or rats treated 4 days before study with saline. By comparison, rats pretreated with vinblastine or saline 1 day before study had increased blood neutrophils and decreased gastrocnemius muscle contractile function after ischemia-reperfusion compared with untreated rats. In addition, numbers of neutrophils in gastrocnemius muscles paralleled numbers of blood neutrophils and correlated with gastrocnemius muscle edema and contractile function after ischemia and reperfusion. The results indicate that neutrophils accumulate and may play an important role in the genesis of skeletal muscle contractile dysfunction after ischemia-reperfusion.


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