AJP - Heart and Circulatory Physiology, Vol 259, Issue 6 1781-H1788, Copyright © 1990 by American Physiological Society

ARTICLES

Heart and brain nucleotide pools during hemorrhage and resuscitation

J. W. Horton and G. McDonald
Department of Surgery, University of Texas Southwestern Medical Center, Dallas 75235.

Sequential 31P nuclear magnetic resonance (NMR) spectra were measured in adult dogs to determine the relationship between cardiac function and myocardial intracellular pH (pHi) and phosphorylated energy metabolites during 2 h of hemorrhagic shock. Simultaneous measurements of coronary blood flow (radioactive microspheres), arterial and coronary sinus pH, blood gases, and oxygen content were performed. In addition, changes in brain NMR spectra were correlated with changes in cerebral blood flow during shock. Two hurs of hypovolemic shock resulted in significant decreases in phosphocreatine (PCr), PCr-to-ATP ratio, and pHi, whereas Pi rose significantly relative to baseline values. Return of shed blood and crystalloid fluid resuscitation improved cerebral and coronary perfusion and returned cardiac contractile function to near baseline values. We conclude that severe and sustained hemorrhagic shock produced significant alterations in brain and heart phosphorylated metabolites as well as significant intracellular acidosis; however, these changes in energy metabolites were reversible with adequate fluid resuscitation from shock.

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				P. D. Mongan, J. Capacchione, J. L. Fontana, S. West, and R. Bunger Pyruvate improves cerebral metabolism during hemorrhagic shock Am J Physiol Heart Circ Physiol, August 1, 2001; 281(2): H854 - H864. [Abstract] [Full Text] [PDF]