| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Heart and Circulatory Physiology, Vol 259, Issue 6 1767-H1773, Copyright © 1990 by American Physiological Society
ARTICLES |
M. M. Pike, M. Kitakaze and E. Marban
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
23Na nuclear magnetic resonance (NMR) spectroscopy was utilized to measure intracellular Na+ in perfused ferret hearts exposed to the shift reagent dysprosium triethylenetramine-hexa-acetic acid [Dy(TTHA)3-]. The intracellular Na+ signal was small under normal perfusion conditions; resolution was enhanced by using a Jump-Return NMR pulse protocol. During 20 min of total global ischemia at 30 degrees C, intracellular Na+ concentration ([Na+]i) increased steadily to a peak value fivefold greater than control. [Na+]i declined monotonically back to control levels within 9 min of reperfusion. In contrast, the mean contractile pressure only recovered to 54% of control levels. Thus major alterations in Na+ homeostasis occur during severe ischemia. [Na+] recovers rapidly during reperfusion and is therefore dissociated from the lingering postischemic depression of contractile function known as "stunning."
This article has been cited by other articles:
|
|
 |
|
  E. Murphy and C. Steenbergen Ion Transport and Energetics During Cell Death and Protection Physiology, April 1, 2008; 23(2): 115 - 123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Bollensdorff, A. Knopp, C. Biskup, T. Zimmer, and K. Benndorf Na+ current through KATP channels: consequences for Na+ and K+ fluxes during early myocardial ischemia Am J Physiol Heart Circ Physiol, January 1, 2004; 286(1): H283 - H295. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. An, S. G. Varadarajan, A. Camara, Q. Chen, E. Novalija, G. J. Gross, and D. F. Stowe Blocking Na+/H+ exchange reduces [Na+]i and [Ca2+]i load after ischemia and improves function in intact hearts Am J Physiol Heart Circ Physiol, December 1, 2001; 281(6): H2398 - H2409. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. E. Rochitte, R. J. Kim, H. B. Hillenbrand, E.-l. Chen, and J. A. C. Lima Microvascular Integrity and the Time Course of Myocardial Sodium Accumulation After Acute Infarction Circ. Res., October 13, 2000; 87(8): 648 - 655. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. I. Goldhaber Sodium-Calcium Exchange : The Phantom Menace Circ. Res., November 26, 1999; 85(11): 982 - 984. [Full Text] [PDF]
|
|
|
|
|
|
H. R. Cross, C. Steenbergen, R. J. Lefkowitz, W. J. Koch, and E. Murphy Overexpression of the Cardiac {beta}2-Adrenergic Receptor and Expression of a {beta}-Adrenergic Receptor Kinase-1 ({beta}ARK1) Inhibitor Both Increase Myocardial Contractility but Have Differential Effects on Susceptibility to Ischemic Injury Circ. Res., November 26, 1999; 85(11): 1077 - 1084. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Kim, R. M. Judd, E.-L. Chen, D. S. Fieno, T. B. Parrish, and J. A. C. Lima Relationship of Elevated 23Na Magnetic Resonance Image Intensity to Infarct Size After Acute Reperfused Myocardial Infarction Circulation, July 13, 1999; 100(2): 185 - 192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Imahashi, H. Kusuoka, K. Hashimoto, J. Yoshioka, H. Yamaguchi, and T. Nishimura Intracellular Sodium Accumulation During Ischemia as the Substrate for Reperfusion Injury Circ. Res., June 25, 1999; 84(12): 1401 - 1406. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-O. Park, X.-H. Xiao, and D. G. Allen Changes in intracellular Na+ and pH in rat heart during ischemia: role of Na+/H+ exchanger Am J Physiol Heart Circ Physiol, May 1, 1999; 276(5): H1581 - H1590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Fieno, R. J. Kim, W. G. Rehwald, and R. M. Judd Physiological Basis for Potassium (39K) Magnetic Resonance Imaging of the Heart Circ. Res., April 30, 1999; 84(8): 913 - 920. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Bolli and E. Marban Molecular and Cellular Mechanisms of Myocardial Stunning Physiol Rev, April 1, 1999; 79(2): 609 - 634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. R. Cross, L. Lu, C. Steenbergen, K. D. Philipson, and E. Murphy Overexpression of the Cardiac Na+/Ca2+ Exchanger Increases Susceptibility to Ischemia/Reperfusion Injury in Male, but Not Female, Transgenic Mice Circ. Res., December 14, 1998; 83(12): 1215 - 1223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Kim, J. A. C. Lima, E.-L. Chen, S. B. Reeder, F. J. Klocke, E. A. Zerhouni, and R. M. Judd Fast 23Na Magnetic Resonance Imaging of Acute Reperfused Myocardial Infarction : Potential to Assess Myocardial Viability Circulation, April 1, 1997; 95(7): 1877 - 1885. [Abstract] [Full Text]
|
|
|
|
|
|
M. M. Pike, C. S. Luo, S. Yanagida, G. R. Hageman, and P. G. Anderson 23Na and 31P Nuclear Magnetic Resonance Studies of Ischemia-Induced Ventricular Fibrillation : Alterations of Intracellular Na+ and Cellular Energy Circ. Res., August 1, 1995; 77(2): 394 - 406. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
