| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Heart and Circulatory Physiology, Vol 259, Issue 5 1586-H1594, Copyright © 1990 by American Physiological Society
ARTICLES |
M. A. Hill, J. C. Falcone and G. A. Meininger
Microcirculation Research Institute, College of Medicine, Texas A & M University, College Station 77843.
Little information exists as to the cellular events that couple the myogenic contractile response of an arteriole to an acute rise in intravascular pressure. The aim of this study was to examine whether protein kinase C (PKC), which has been implicated in the contractile response to agonists, contributes to myogenic vasoconstriction of cremaster muscle arterioles. Studies were performed on anesthetized rats, enclosed in an airtight Plexiglas box, with the cremaster exteriorized into a bath containing Kreb's solution. Pressure in the box was increased to elevate intravascular pressure by 20 mmHg. To examine PKC involvement, studies were performed in the absence or presence of inhibitors of PKC: H 7 (10(-9)-10(-5) M) or staurosporine (10(-10)-10(-7) M). Inhibitors were added to the tissue bath and produced no observable systemic effects or alterations in arteriolar diameter. Third-order arteriole (16 +/- 1 microns diam) responses to these agents and alterations in intravascular pressure were monitored by in vivo microscopy and vessel diameter was measured with a video caliper. H 7 produced a concentration-dependent inhibition of myogenic vasoconstriction, inhibiting the extent of constriction by 75% at 10(-5) M. Similarly, staurosporine caused a concentration-dependent inhibition of pressure-induced constriction. At 10(-7) M staurosporine the myogenic response was inhibited by 82%. Further support for a role for PKC in the myogenic response was provided by the observation that indolactam (10(-6) M), a stimulator of PKC activity, induced myogenic reactivity in first-order arterioles, which under basal conditions show passive distension to increased intravascular pressure.(ABSTRACT TRUNCATED AT 250 WORDS)
This article has been cited by other articles:
|
|
 |
|
  C. A. Cobine, B. P. Callaghan, and K. D. Keef Role of L-type calcium channels and PKC in active tone development in rabbit coronary artery Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H3079 - H3088. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Earley, S. V. Straub, and J. E. Brayden Protein kinase C regulates vascular myogenic tone through activation of TRPM4 Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H2613 - H2622. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Hill and M. J. Davis Coupling a change in intraluminal pressure to vascular smooth muscle depolarization: still stretching for an explanation Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H2570 - H2572. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Just Mechanisms of renal blood flow autoregulation: dynamics and contributions Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R1 - R17. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Ito, Y. P. R. Jarajapu, M. B Grant, and H. J Knot Characteristics of myogenic tone in the rat ophthalmic artery Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H360 - H368. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Xiao, X. Huang, L. D. Longo, W. J. Pearce, and L. Zhang Regulation of baseline Ca2+ sensitivity in permeabilized uterine arteries: effect of pregnancy Am J Physiol Heart Circ Physiol, July 1, 2006; 291(1): H413 - H420. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Xiao, J. N. Buchholz, and L. Zhang Pregnancy attenuates uterine artery pressure-dependent vascular tone: role of PKC/ERK pathway Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2337 - H2343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. P. R. Jarajapu and H. J. Knot Relative contribution of Rho kinase and protein kinase C to myogenic tone in rat cerebral arteries in hypertension Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H1917 - H1922. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Martinez-Lemus, T. Crow, M. J. Davis, and G. A. Meininger {alpha}v{beta}3- and {alpha}5{beta}1-integrin blockade inhibits myogenic constriction of skeletal muscle resistance arterioles Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H322 - H329. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. H. Korzick, M. H. Laughlin, and D. K. Bowles Alterations in PKC signaling underlie enhanced myogenic tone in exercise-trained porcine coronary resistance arteries J Appl Physiol, April 1, 2004; 96(4): 1425 - 1432. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Y. Su, K. M. Reber, C. A. Nankervis, and P. T. Nowicki Development of the myogenic response in postnatal intestine: role of PKC Am J Physiol Gastrointest Liver Physiol, March 1, 2003; 284(3): G445 - G452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Massett, Z. Ungvari, A. Csiszar, G. Kaley, and A. Koller Different roles of PKC and MAP kinases in arteriolar constrictions to pressure and agonists Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2282 - H2287. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Lagaud, N. Gaudreault, E. D. W. Moore, C. van Breemen, and I. Laher Pressure-dependent myogenic constriction of cerebral arteries occurs independently of voltage-dependent activation Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2187 - H2195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. F. Slish, D. G. Welsh, and J. E. Brayden Diacylglycerol and protein kinase C activate cation channels involved in myogenic tone Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2196 - H2201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Brekke, N. I. Gokina, and G. Osol Vascular smooth muscle cell stress as a determinant of cerebral artery myogenic tone Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2210 - H2216. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Osol, J. F. Brekke, K. McElroy-Yaggy, and N. I. Gokina Myogenic tone, reactivity, and forced dilatation: a three-phase model of in vitro arterial myogenic behavior Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2260 - H2267. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Storme, T. A. Parker, J. P. Kinsella, R. L. Rairigh, and S. H. Abman Chronic hypertension impairs flow-induced vasodilation and augments the myogenic response in fetal lung Am J Physiol Lung Cell Mol Physiol, January 1, 2002; 282(1): L56 - L66. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. V. Murphy, B. E. Spurrell, and M. A. Hill Tyrosine phosphorylation following alterations in arteriolar intraluminal pressure and wall tension Am J Physiol Heart Circ Physiol, September 1, 2001; 281(3): H1047 - H1056. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Hill, H. Zou, S. J. Potocnik, G. A. Meininger, and M. J. Davis Signal Transduction in Smooth Muscle: Invited Review: Arteriolar smooth muscle mechanotransduction: Ca2+ signaling pathways underlying myogenic reactivity J Appl Physiol, August 1, 2001; 91(2): 973 - 983. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rapacon-Baker, F. Zhang, M. L. Pucci, H. Guan, and A. Nasjletti Expression of myogenic constrictor tone in the aorta of hypertensive rats Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2001; 280(4): R968 - R975. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Zhang, T. W. Hein, and L. Kuo Transmural difference in coronary arteriolar dilation to adenosine: effect of luminal pressure and KATP channels Am J Physiol Heart Circ Physiol, December 1, 2000; 279(6): H2612 - H2619. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Dessy, N. Matsuda, J. Hulvershorn, C. L. Sougnez, F. W. Sellke, and K. G. Morgan Evidence for involvement of the PKC-alpha isoform in myogenic contractions of the coronary microcirculation Am J Physiol Heart Circ Physiol, September 1, 2000; 279(3): H916 - H923. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Gebremedhin, A. R. Lange, T. F. Lowry, M. R. Taheri, E. K. Birks, A. G. Hudetz, J. Narayanan, J. R. Falck, H. Okamoto, R. J. Roman, et al. Production of 20-HETE and Its Role in Autoregulation of Cerebral Blood Flow Circ. Res., July 7, 2000; 87(1): 60 - 65. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. R. Nurkiewicz and M. A. Boegehold Reinforcement of arteriolar myogenic activity by endogenous ANG II: susceptibility to dietary salt Am J Physiol Heart Circ Physiol, July 1, 2000; 279(1): H269 - H278. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Looft-Wilson and C. V. Gisolfi Rat small mesenteric artery function after hindlimb suspension J Appl Physiol, April 1, 2000; 88(4): 1199 - 1206. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Davis and M. A. Hill Signaling Mechanisms Underlying the Vascular Myogenic Response Physiol Rev, April 1, 1999; 79(2): 387 - 423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. B. Campbell and D. R. Harder Endothelium-Derived Hyperpolarizing Factors and Vascular Cytochrome P450 Metabolites of Arachidonic Acid in the Regulation of Tone Circ. Res., March 5, 1999; 84(4): 484 - 488. [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Smeda, S. King, and D. R. Harder Cerebrovascular Alterations in Protein Kinase C–Mediated Constriction in Stroke-Prone Rats • Editorial Comment Stroke, March 1, 1999; 30(3): 656 - 661. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Akopov, L. Zhang, and W. J. Pearce Regulation of Ca2+ sensitization by PKC and rho proteins in ovine cerebral arteries: effects of artery size and age Am J Physiol Heart Circ Physiol, September 1, 1998; 275(3): H930 - H939. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Kirton and R. Loutzenhiser Alterations in basal protein kinase C activity modulate renal afferent arteriolar myogenic reactivity Am J Physiol Heart Circ Physiol, August 1, 1998; 275(2): H467 - H475. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. VanBavel, J. P. M. Wesselman, and J. A. E. Spaan Myogenic Activation and Calcium Sensitivity of Cannulated Rat Mesenteric Small Arteries Circ. Res., February 9, 1998; 82(2): 210 - 220. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. T. Franklin, C. L.-A. Wang, and L. P. Adam Stretch-dependent activation and desensitization of mitogen-activated protein kinase in carotid arteries Am J Physiol Cell Physiol, December 1, 1997; 273(6): C1819 - C1827. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Chrissobolis and C. G. Sobey Evidence That Rho-Kinase Activity Contributes to Cerebral Vascular Tone In Vivo and Is Enhanced During Chronic Hypertension : Comparison With Protein Kinase C Circ. Res., April 27, 2001; 88(8): 774 - 779. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
