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Am J Physiol Heart Circ Physiol 259: H1575-H1585, 1990;
0363-6135/90 $5.00
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AJP - Heart and Circulatory Physiology, Vol 259, Issue 5 1575-H1585, Copyright © 1990 by American Physiological Society

ARTICLES

Beta-receptor subtypes in the canine coronary circulation

M. G. Trivella, T. P. Broten and E. O. Feigl
Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle 98195.

The principal difficulty in determining the subtype of coronary vascular beta-receptors in vivo is to avoid the local metabolic coronary vasodilation that occurs secondary to activation of myocardial beta-receptors. Therefore, a nonbeating cardiac preparation without chronotropic or inotropic effects is needed. In this study, the coronary circulation was perfused at constant pressure in closed-chest chloralose-anesthetized dogs. The increase in coronary blood flow due to intracoronary injections of the combined beta 1- and beta 2-agonist isoproterenol was determined during prolonged asystoles after the cessation of cardiac pacing in atrioventricular heart-blocked animals. Both beta 1-selective (practolol and L 650,744) and beta 2-selective (ICI 118,551) antagonists blocked isoproterenol-induced coronary vasodilation. In contrast, isoproterenol vasodilation in the femoral circulation was blocked by beta 2- but not by beta 1-selective antagonists. In conclusion, both beta 1- and beta 2-receptors in coronary resistance vessels are stimulated by isoproterenol to produce vasodilation during prolonged asystoles, when cardiac chronotropic and inotropic effects are absent.


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