| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Heart and Circulatory Physiology, Vol 259, Issue 5 1471-H1476, Copyright © 1990 by American Physiological Society
ARTICLES |
C. S. Tietjan, C. G. Tribble, J. M. Gidday, C. L. Phillips, L. Belardinelli, R. Rubio and R. M. Berne
Department of Physiology, University of Virginia, Charlottesville 22908.
Epicardial porous disks were used to estimate left ventricular interstitial fluid adenosine in the isolated guinea pig heart perfused at constant flow. To validate this technique, adenosine was infused with 0.5 microM dipyridamole and 5 microM erythro-4-(2-hydroxy-3-nonyl)adenine hydrochloride (EHNA) to inhibit adenosine uptake and deamination, respectively. Under these conditions, with 6 or 12 microM adenosine in the arterial infusate, the venous and steady-state left ventricular disk adenosine values equaled those of the perfusion fluid, reflecting the expected equilibration between vascular and left ventricular interstitial fluid (disk) compartments. The concentration of endogenous adenosine in the interstitial fluid as estimated by the epicardial disks under control conditions was 0.28 +/- 0.03 microM with a concomitant coronary sinus concentration of 0.004 +/- 0.001 microM. We conclude that a marked adenosine gradient exists between the interstitial fluid and the vascular space and that disk adenosine measurements provide a useful index of left ventricular interstitial fluid adenosine.
This article has been cited by other articles:
|
|
 |
|
  R. Rubio and G. Ceballos Sole activation of three luminal adenosine receptor subtypes in different parts of coronary vasculature Am J Physiol Heart Circ Physiol, January 1, 2003; 284(1): H204 - H214. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. Heaps and D. K. Bowles Gender-specific K+-channel contribution to adenosine-induced relaxation in coronary arterioles J Appl Physiol, February 1, 2002; 92(2): 550 - 558. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yada, K. N. Richmond, R. van Bibber, K. Kroll, and E. O. Feigl Role of adenosine in local metabolic coronary vasodilation Am J Physiol Heart Circ Physiol, May 1, 1999; 276(5): H1425 - H1433. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Lasley and R. M. Mentzer Jr. Dose-Dependent Effects of Adenosine on Interstitial Fluid Adenosine and Postischemic Function in the Isolated Rat Heart J. Pharmacol. Exp. Ther., August 1, 1998; 286(2): 806 - 811. [Abstract] [Full Text]
|
|
|
|
|
|
L. Belardinelli, J. C. Shryock, S. Snowdy, Y. Zhang, A. Monopoli, G. Lozza, E. Ongini, R. A. Olsson, and D. M. Dennis The A2A Adenosine Receptor Mediates Coronary Vasodilation J. Pharmacol. Exp. Ther., March 1, 1998; 284(3): 1066 - 1073. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Srinivas, J. C. Shryock, D. M. Dennis, S. P. Baker, and L. Belardinelli Differential A1 Adenosine Receptor Reserve for Two Actions of Adenosine on Guinea Pig Atrial Myocytes Mol. Pharmacol., October 1, 1997; 52(4): 683 - 691. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. M. Dennis, M.J. P. Raatikainen, J. R. Martens, and L. Belardinelli Modulation of Atrioventricular Nodal Function by Metabolic and Allosteric Regulators of Endogenous Adenosine in Guinea Pig Heart Circulation, November 15, 1996; 94(10): 2551 - 2559. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. W. Stepp, R. Van Bibber, K. Kroll, and E. O. Feigl Quantitative Relation Between Interstitial Adenosine Concentration and Coronary Blood Flow Circ. Res., September 1, 1996; 79(3): 601 - 610. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
