AJP - Heart Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 259: H1337-H1342, 1990;
0363-6135/90 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Julien, C.
Right arrow Articles by Sassard, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Julien, C.
Right arrow Articles by Sassard, J.

AJP - Heart and Circulatory Physiology, Vol 259, Issue 5 1337-H1342, Copyright © 1990 by American Physiological Society

ARTICLES

Effects of sympathectomy on blood pressure and its variability in conscious rats

C. Julien, P. Kandza, C. Barres, M. Lo, C. Cerutti and J. Sassard
Department of Physiology and Clinical Pharmacology, Centre National de la Recherche Scientifique, Unite de Recherche Associee RA 606, Faculty of Pharmacy, Lyon, France.

To further assess the role of the sympathetic nervous system (SNS) in the control of blood pressure (BP), continuous recordings of BP were performed in conscious freely moving rats that had received daily injections of guanethidine or saline from 7 to 90 days of age. Guanethidine extensively destroyed the peripheral sympathetic fibers as indicated by marked decreases in the norepinephrine content of the heart and kidneys and the absence of pressor response to tyramine injection. Such a chronic sympathectomy did not alter the BP and heart rate (HR) levels but markedly enhanced the BP variability while the HR variability and the sensitivity of the cardiac baroreceptor reflex were not altered. Angiotensin-converting enzyme inhibition with perindopril induced a rapid fall in BP and normalized the BP variability in sympathectomized animals. It is concluded that in rats, the SNS is not necessary for the full development of the BP level but is essential to buffer the spontaneous variability of BP. After sympathectomy, BP is maintained at nearly normal levels mainly through activation of the renin angiotensin system.


This article has been cited by other articles:


Home page
 J. Physiol.Home page
B. Fromy, D. Sigaudo-Roussel, C. Baron, Y. Roquelaure, G. Leftheriotis, and J. L. Saumet
Neuroendocrine pathway involvement in the loss of the cutaneous pressure-induced vasodilatation during acute pain in rats
J. Physiol., February 15, 2007; 579(1): 247 - 254.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
K. D. Monahan, H. Tanaka, F. A. Dinenno, and D. R. Seals
Central Arterial Compliance Is Associated With Age- and Habitual Exercise-Related Differences in Cardiovagal Baroreflex Sensitivity
Circulation, October 2, 2001; 104(14): 1627 - 1632.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
M. Makino, H. Hayashi, H. Takezawa, M. Hirai, H. Saito, and S. Ebihara
Circadian Rhythms of Cardiovascular Functions Are Modulated by the Baroreflex and the Autonomic Nervous System in the Rat
Circulation, September 2, 1997; 96(5): 1667 - 1674.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online