| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Heart and Circulatory Physiology, Vol 259, Issue 3 668-H673, Copyright © 1990 by American Physiological Society
ARTICLES |
J. E. Brayden
Department of Pharmacology, College of Medicine, University of Vermont, Burlington 05405.
Acetylcholine (ACh)-induced hyperpolarization of cerebral arteries requires a functional endothelium. The hyperpolarization is reversed by potassium-channel blockers. The goal of this study was to determine whether the hyperpolarization is causally related to endothelium-dependent dilation of isolated cerebral arteries. ACh hyperpolarized rabbit middle cerebral arteries by up to 19 mV. The hyperpolarizations were sustained and did not occur in arteries without endothelial cells or in the presence of potassium-channel inhibitors (3 x 10(-6) M glibenclamide or 5 x 10(-5) M BaCl2). ACh-induced dilator responses were inhibited but not abolished by glibenclamide or BaCl2. Methylene blue also inhibited the dilator responses, and a combination of glibenclamide or BaCl2 and methylene blue greatly diminished the dilation. Nitric oxide relaxed but did not hyperpolarize the vascular smooth muscle cells, and BaCl2 had no effect on the nitric oxide-induced relaxations. These data indicate that the overall cerebral arterial dilator response to ACh is determined by the combined effects of membrane hyperpolarization, which closes voltage-dependent calcium channels, and the actions of a second endothelial factor, probably endothelium-derived relaxing factor.
This article has been cited by other articles:
|
|
 |
|
  L. S. Harrington, M. J. Carrier, N. Gallagher, D. Gilroy, C. J. Garland, and J. A. Mitchell Elucidation of the temporal relationship between endothelial-derived NO and EDHF in mesenteric vessels Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1682 - H1688. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Samora, J. C. Frisbee, and M. A. Boegehold Growth-dependent changes in endothelial factors regulating arteriolar tone Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H207 - H214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Kim, J. Han, and E. Kim Effects of prostaglandin F2alpha on membrane currents in rabbit middle cerebral arterial smooth muscle cells Am J Physiol Heart Circ Physiol, March 1, 2003; 284(3): H1018 - H1027. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Bracamonte, M. Jayachandran, K. S. Rud, and V. M. Miller Acute effects of 17beta -estradiol on femoral veins from adult gonadally intact and ovariectomized female pigs Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2389 - H2396. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Yang, Y.-C. Liu, W. Zou, A. P. C. Yim, and G.-W. He Protective effect of magnesium on the endothelial function mediated by endothelium-derived hyperpolarizing factor in coronary arteries during cardioplegic arrest in a porcine model J. Thorac. Cardiovasc. Surg., August 1, 2002; 124(2): 361 - 370. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Golding and T. E. Kepler Role of estrogen in modulating EDHF-mediated dilations in the female rat middle cerebral artery Am J Physiol Heart Circ Physiol, June 1, 2001; 280(6): H2417 - H2423. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Coats, F. Johnston, J. MacDonald, J. J. V. McMurray, and C. Hillier Endothelium-Derived Hyperpolarizing Factor : Identification and Mechanisms of Action in Human Subcutaneous Resistance Arteries Circulation, March 27, 2001; 103(12): 1702 - 1708. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Kaye, B. J. De Witt, M. Anwar, D. E. Smith, C. J. Feng, P. J. Kadowitz, and B. D. Nossaman Analysis of responses of garlic derivatives in the pulmonary vascular bed of the rat J Appl Physiol, July 1, 2000; 89(1): 353 - 358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. I. Gokina and J. A. Bevan Histamine-induced depolarization: ionic mechanisms and role in sustained contraction of rabbit cerebral arteries Am J Physiol Heart Circ Physiol, June 1, 2000; 278(6): H2094 - H2104. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Shimizu and R. J. Paul Hypoxia and Alkalinization Inhibit Endothelium-Derived Nitric Oxide But Not Endothelium-Derived Hyperpolarizing Factor Responses in Porcine Coronary Artery J. Pharmacol. Exp. Ther., October 1, 1999; 291(1): 335 - 344. [Abstract] [Full Text]
|
|
|
|
 |
|
 Y. Tomiyama, J. E. Brian Jr, M. M. Todd, and W. Pearce Cerebral Blood Flow During Hemodilution and Hypoxia in Rats : Role of ATP-Sensitive Potassium Channels • Editorial Comment: Role of ATP-Sensitive Potassium Channels Stroke, September 1, 1999; 30(9): 1942 - 1948. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. You, T. D. Johnson, S. P. Marrelli, J.-V. Mombouli, R. M. Bryan Jr, and F. M. Faraci P2u Receptor–Mediated Release of Endothelium-Derived Relaxing Factor/Nitric Oxide and Endothelium-Derived Hyperpolarizing Factor From Cerebrovascular Endothelium in Rats • Editorial Comment Stroke, May 1, 1999; 30(5): 1125 - 1133. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Storme, R. L. Rairigh, T. A. Parker, D. N. Cornfield, J. P. Kinsella, and S. H. Abman K+-channel blockade inhibits shear stress-induced pulmonary vasodilation in the ovine fetus Am J Physiol Lung Cell Mol Physiol, February 1, 1999; 276(2): L220 - L228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Asano, R. C. Koehler, J. A. Ulatowski, R. J. Traystman, and E. Bucci Effect of cross-linked hemoglobin transfusion on endothelial-dependent dilation in cat pial arterioles Am J Physiol Heart Circ Physiol, October 1, 1998; 275(4): H1313 - H1321. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Abderrahmane, D. Salvail, M. Dumoulin, J. Garon, A. Cadieux, and E. Rousseau Direct Activation of KCa Channel in Airway Smooth Muscle by Nitric Oxide: Involvement of a Nitrothiosylation Mechanism? Am. J. Respir. Cell Mol. Biol., September 1, 1998; 19(3): 485 - 497. [Abstract] [Full Text]
|
|
|
|
 |
|
 E. Thorin, P. L. Huang, M. C. Fishman, and J. A. Bevan Nitric Oxide Inhibits {alpha}2-Adrenoceptor–Mediated Endothelium-Dependent Vasodilation Circ. Res., June 29, 1998; 82(12): 1323 - 1329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Popp, I. Fleming, and R. Busse Pulsatile Stretch in Coronary Arteries Elicits Release of Endothelium-Derived Hyperpolarizing Factor : A Modulator of Arterial Compliance Circ. Res., April 6, 1998; 82(6): 696 - 703. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Okamura, K. Ayajiki, and N. Toda Monkey corpus cavernosum relaxation mediated by NO and other relaxing factor derived from nerves Am J Physiol Heart Circ Physiol, April 1, 1998; 274(4): H1075 - H1081. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. M. FARACI and D. D. HEISTAD Regulation of the Cerebral Circulation: Role of Endothelium and Potassium Channels Physiol Rev, January 1, 1998; 78(1): 53 - 97. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. Welsh and S. S. Segal Endothelial and smooth muscle cell conduction in arterioles controlling blood flow Am J Physiol Heart Circ Physiol, January 1, 1998; 274(1): H178 - H186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G.-W. He and C.-Q. Yang SUPERIORITY OF HYPERPOLARIZING TO DEPOLARIZING CARDIOPLEGIA IN PROTECTION OF CORONARY ENDOTHELIAL FUNCTION J. Thorac. Cardiovasc. Surg., October 1, 1997; 114(4): 643 - 650. [Abstract] [Full Text]
|
|
|
|
 |
|
 E. Thorin, S. M. Shreeve, N. Thorin-Trescases, and J. A. Bevan Reversal of Endothelin-1 Release by Stimulation of Endothelial {alpha}2-Adrenoceptor Contributes to Cerebral Vasorelaxation Hypertension, October 1, 1997; 30(4): 830 - 836. [Abstract] [Full Text]
|
|
|
|
|
|
H. Onoue and Z. S. Katusic Role of Potassium Channels in Relaxations of Canine Middle Cerebral Arteries Induced by Nitric Oxide Donors Stroke, June 1, 1997; 28(6): 1264 - 1271. [Abstract] [Full Text]
|
|
|
|
|
|
G.-W. He, C.-Q. Yang, and J.-A. Yang DEPOLARIZING CARDIAC ARREST AND ENDOTHELIUM-DERIVED HYPERPOLARIZING FACTOR-MEDIATED HYPERPOLARIZATION AND RELAXATION IN CORONARY ARTERIES: THE EFFECT AND MECHANISM J. Thorac. Cardiovasc. Surg., May 1, 1997; 113(5): 932 - 941. [Abstract] [Full Text]
|
|
|
|
 |
|
 G.-W. He Hyperkalemia Exposure Impairs EDHF-Mediated Endothelial Function in the Human Coronary Artery Ann. Thorac. Surg., January 1, 1997; 63(1): 84 - 87. [Abstract] [Full Text]
|
|
|
|
|
|
G. C. Wellman, A. D. Bonev, M. T. Nelson, and J. E. Brayden Gender Differences in Coronary Artery Diameter Involve Estrogen, Nitric Oxide, and Ca2+-Dependent K+ Channels Circ. Res., November 1, 1996; 79(5): 1024 - 1030. [Abstract] [Full Text]
|
|
|
|
|
|
R. Paterno, F. M. Faraci, D. D. Heistad, and J. E. Brayden Role of Ca2+-Dependent K+ Channels in Cerebral Vasodilatation Induced by Increases in Cyclic GMP and Cyclic AMP in the Rat Stroke, September 1, 1996; 27(9): 1603 - 1608. [Abstract] [Full Text]
|
|
|
|
|
|
G.-W. He and C.-Q. Yang Hyperkalemia Alters Endothelium-Dependent Relaxation Through Non-Nitric Oxide and Noncyclooxygenase Pathway: A Mechanism for Coronary Dysfunction due to Cardioplegia Ann. Thorac. Surg., May 1, 1996; 61(5): 1394 - 1399. [Abstract] [Full Text]
|
|
|
|
|
|
R. A. Cohen and P. M. Vanhoutte Endothelium-Dependent Hyperpolarization : Beyond Nitric Oxide and Cyclic GMP Circulation, December 1, 1995; 92(11): 3337 - 3349. [Full Text]
|
|
|
|
|
|
T. Kitazono, F. M. Faraci, H. Taguchi, and D. D. Heistad Role of Potassium Channels in Cerebral Blood Vessels Stroke, September 1, 1995; 26(9): 1713 - 1723. [Abstract] [Full Text]
|
|
|
|
|
|
H. Taguchi, D. D. Heistad, T. Kitazono, and F. M. Faraci Dilatation of Cerebral Arterioles in Response to Activation of Adenylate Cyclase Is Dependent on Activation of Ca2+-Dependent K+ Channels Circ. Res., June 1, 1995; 76(6): 1057 - 1062. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
