AJP - Heart Add DOIs to your references at manuscript stage!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 258: H1899-H1905, 1990;
0363-6135/90 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bardy, G. H.
Right arrow Articles by Reichenbach, D. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bardy, G. H.
Right arrow Articles by Reichenbach, D. D.

AJP - Heart and Circulatory Physiology, Vol 258, Issue 6 1899-H1905, Copyright © 1990 by American Physiological Society

ARTICLES

Radio-frequency ablation: effect of voltage and pulse duration on canine myocardium

G. H. Bardy, P. L. Sawyer, G. W. Johnson and D. D. Reichenbach
Department of Medicine, University of Washington, Seattle 98195.

The purpose of this investigation was to examine in vivo the relationship of radio-frequency (RF) pulse voltage and duration on the volume of tissue injury. RF 500-kHz pulses of 20-, 40-, and 60-V amplitude (RMS) were applied to the epicardium of 18 dogs for pulsing periods of 5-20 s. Systematic and quantitative tissue analysis was then performed after 30 days. No chronic lesions were evident on microscopic examination for 20-V RF pulse applications up to 15 s. Application of 20-V pulses for 20 s produced small lesions having a volume of 2.4 +/- 0.7 mm3. At 40 V, the volume of tissue injury ranged from 39.1 +/- 10.3 mm3 for 5 s of pulse application to 128.8 +/- 24.8 mm3 for 20 s of pulse application. Over the first 15 s of 40-V pulse application, the volume of tissue injury increased as pulse application time increased. There was no further increase in tissue injury for 40-V pulsing durations greater than 15 s. At 60 V, volumes of tissue injury ranged from 122.7 +/- 33.5 mm3 at 5 s to 313.6 +/- 73.7 mm3 at 20 s. Lesion size increased significantly for pulse durations of up to 10 s. Thereafter, 60-V pulses yielded little increase in tissue injury. In addition, persistent 60-V pulsing for periods greater than 9 s duration resulted in arcing and tissue vaporization in 28% of the applications. Thus RF energy is limited in its ability to create safe and effective tissue injury.(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
 Eur. J. Cardiothorac. Surg.Home page
R. G. Demaria, P. Page, T. K. Leung, M. Dubuc, O. Malo, M. Carrier, and L. P. Perrault
Surgical radiofrequency ablation induces coronary endothelial dysfunction in porcine coronary arteries
Eur. J. Cardiothorac. Surg., March 1, 2003; 23(3): 277 - 282.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
S. P. Thomas, D. J.R. Guy, A. C. Boyd, V. E. Eipper, D. L. Ross, and R. B. Chard
Comparison of epicardial and endocardial linear ablation using handheld probes
Ann. Thorac. Surg., February 1, 2003; 75(2): 543 - 548.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
S. P. Thomas, I. A. Nicholson, G. R. Nunn, and D. L. Ross
Radiofrequency lesions produced by handheld temperature controlled probes for use in atrial fibrillation surgery
Eur. J. Cardiothorac. Surg., December 1, 2001; 20(6): 1188 - 1193.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online