| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Heart and Circulatory Physiology, Vol 258, Issue 6 1840-H1846, Copyright © 1990 by American Physiological Society
ARTICLES |
R. L. Haberl, F. Anneser, A. Villringer and K. M. Einhaupl
Department of Neurology, University of Munich, Federal Republic of Germany.
We evaluated the response of cerebral arterioles to angiotensin II (ANG II) in anesthetized rats equipped with a closed cranial window. Topical application of 10(-10)-10(-5) M ANG II induced dose-dependent arteriolar vasodilation. Maximum vasodilation of 24 +/- 2.2% (+/- SE) was attained at a concentration of 10(-6) M ANG II. The dilation in response to ANG II was blocked by 3 micrograms/ml indomethacin, a cyclooxygenase inhibitor, and was reversed to minimal vasoconstriction by 10(-5) M methylene blue, a substance that has been reported to eliminate endothelium-dependent vasodilation. Coapplication of indomethacin with methylene blue reduced the arteriolar response to ANG II to a similar extent as the application of indomethacin alone. Indomethacin or methylene blue did not inhibit the vasodilation induced by 10(-5) M adenosine, which is not endothelium and cyclooxygenase dependent. Mercury light illumination of the pial vessels after intravenous injection of fluorescein dye, a technique that has been used by others to functionally damage endothelial cells, reversed ANG II (10(-6) M)-induced vasodilation into a -14.2 +/- 2.3% constriction while not affecting the response to adenosine. Our data suggest that ANG II produces vasodilator responses of rat cerebral arterioles by the release of a factor that is derived from the endothelium and may be generated through a cyclooxygenase-dependent mechanism.
This article has been cited by other articles:
|
|
 |
|
  D. Henrion, N. Kubis, and B. I. Levy Physiological and Pathophysiological Functions of the AT2 Subtype Receptor of Angiotensin II: From Large Arteries to the Microcirculation Hypertension, November 1, 2001; 38(5): 1150 - 1157. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Schmidt, F. Fazekas, G. M. Kostner, C. M. van Duijn, and R. Schmidt Angiotensinogen Gene Promoter Haplotype and Microangiopathy-Related Cerebral Damage : Results of the Austrian Stroke Prevention Study Stroke, February 1, 2001; 32(2): 405 - 412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Dimitropoulou, R. E. White, L. Fuchs, H. Zhang, J. D. Catravas, and G. O. Carrier Angiotensin II Relaxes Microvessels Via the AT2 Receptor and Ca2+-Activated K+ (BKCa) Channels Hypertension, February 1, 2001; 37(2): 301 - 307. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Nishimura, T. Ito, J. M. Saavedra, and K. Sandberg Angiotensin II AT1 Blockade Normalizes Cerebrovascular Autoregulation and Reduces Cerebral Ischemia in Spontaneously Hypertensive Rats Editorial Comment Stroke, October 1, 2000; 31(10): 2478 - 2486. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. de Gasparo, K. J. Catt, T. Inagami, J. W. Wright, and Th. Unger International Union of Pharmacology. XXIII. The Angiotensin II Receptors Pharmacol. Rev., September 1, 2000; 52(3): 415 - 472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Matrougui, L. Loufrani, C. Heymes, B. I. Levy, and D. Henrion Activation of AT2 Receptors by Endogenous Angiotensin II Is Involved in Flow-Induced Dilation in Rat Resistance Arteries Hypertension, October 1, 1999; 34(4): 659 - 665. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. HILL-KAPTURCZAK, M. H. KAPTURCZAK, E. R. BLOCK, J. M. PATEL, T. MALINSKI, K. M. MADSEN, and C. C. TISHER Angiotensin II-Stimulated Nitric Oxide Release from Porcine Pulmonary Endothelium Is Mediated by Angiotensin IV J. Am. Soc. Nephrol., March 1, 1999; 10(3): 481 - 491. [Abstract] [Full Text]
|
|
|
|
 |
|
 E. H. Nora, D. H. Munzenmaier, F. M. Hansen-Smith, J. H. Lombard, and A. S. Greene Localization of the ANG II type 2 receptor in the microcirculation of skeletal muscle Am J Physiol Heart Circ Physiol, October 1, 1998; 275(4): H1395 - H1403. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Pueyo, J.-F. Arnal, J. Rami, and J.-B. Michel Angiotensin II stimulates the production of NO and peroxynitrite in endothelial cells Am J Physiol Cell Physiol, January 1, 1998; 274(1): C214 - C220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. H. Munzenmaier and A. S. Greene Opposing Actions of Angiotensin II on Microvascular Growth and Arterial Blood Pressure Hypertension, March 1, 1996; 27(3): 760 - 765. [Abstract] [Full Text]
|
|
|
|
|
|
R. D. Paula, C. V. Lima, M. C. Khosla, and R. A.S. Santos Angiotensin-(1-7) Potentiates the Hypotensive Effect of Bradykinin in Conscious Rats Hypertension, December 1, 1995; 26(6): 1154 - 1159. [Abstract] [Full Text]
|
|
|
|
|
|
C. M. Boulanger, L. Caputo, and B. I. Levy Endothelial AT1-Mediated Release of Nitric Oxide Decreases Angiotensin II Contractions in Rat Carotid Artery Hypertension, November 1, 1995; 26(5): 752 - 757. [Abstract] [Full Text]
|
|
|
|
|
|
M. A. Maktabi, M. M. Todd, and G. Stachovic Angiotensin II Contributes to Cerebral Vasodilatation During Hypoxia in the Rabbit Stroke, October 1, 1995; 26(10): 1871 - 1876. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
