AJP - Heart AJP: Endocrinology and Metabolism
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol 258: H1806-H1814, 1990;
0363-6135/90 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Braakman, R.
Right arrow Articles by Westerhof, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Braakman, R.
Right arrow Articles by Westerhof, N.

AJP - Heart and Circulatory Physiology, Vol 258, Issue 6 1806-H1814, Copyright © 1990 by American Physiological Society

ARTICLES

Two zero-flow pressure intercepts exist in autoregulating isolated skeletal muscle

R. Braakman, P. Sipkema and N. Westerhof
Laboratory for Physiology, Free University, Amsterdam, The Netherlands.

The autoregulating vascular bed of the isolated canine extensor digitorum longus muscle was investigated for the possible existence of two positive zero-flow pressure axis intercepts, a tone-dependent one and a tone-independent one. An isolated preparation, perfused with autologous blood, was used to exclude effects of collateral flow and nervous and humoral regulation while autoregulation was left intact [mean autoregulatory gain 0.50 +/- 0.24 (SD)]. In a first series of experiments, the steady-state (zero flow) pressure axis intercept [mean 8.9 +/- 2.6 (SD) mmHg, tone independent] and the instantaneous (zero flow) pressure axis intercept [mean 28.5 +/- 9.9 (SD) mmHg, tone dependent] were determined as a function of venous pressure (range: 0-45 mmHg) and were independent of venous pressure until the venous pressure exceeded their respective values. Beyond this point the relations between the venous pressure and the steady-state and instantaneous pressure axis intercept followed the line of identity. The findings agree with the predictions of the vascular waterfall model. In a second series it was shown by means of administration of vasoactive drugs that the instantaneous pressure axis intercept is tone dependent, whereas the steady-state pressure axis intercept is not. It is concluded that there is a (proximal) tone-dependent zero-flow pressure at the arteriolar level and a (distal) tone-independent zero-flow pressure at the venous level.


This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
N. Westerhof, C. Boer, R. R. Lamberts, and P. Sipkema
Cross-talk between cardiac muscle and coronary vasculature.
Physiol Rev, October 1, 2006; 86(4): 1263 - 1308.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. L. Dobson and L. B. Gladden
Effect of rhythmic tetanic skeletal muscle contractions on peak muscle perfusion
J Appl Physiol, January 1, 2003; 94(1): 11 - 19.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. P. Versluis, J. W. Heslinga, P. Sipkema, and N. Westerhof
Microvascular pressure measurement reveals a coronary vascular waterfall in arterioles larger than 110 {micro}m
Am J Physiol Heart Circ Physiol, November 1, 2001; 281(5): H1913 - H1918.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online